421 Recruiting Now

Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 4996 of 421 trials
Not Yet Recruiting·Phase 2·psilocybin

Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot Study

Nantes University Hospital

Gambling Disorder
Not Yet Recruiting·Early Phase 1·psilocybin

Psilocybin Microdosing on Cognition, Mood and Quality of Life

Yale University

Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI
Not Yet Recruiting·Phase 2·psilocybin

Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression

Centre for Addiction and Mental Health

Treatment-Resistant Depression
Not Yet Recruiting·Phase 2·MDMA

MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers

Nautilus Sanctuary

Post-Traumatic Stress DisorderAdjustment Disorders
Not Yet Recruiting·Phase 1·psilocybin

Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study

University of Wisconsin, Madison

Well-Being, PsychologicalPsychedelic Experiences
Not Yet Recruiting·Phase 2·psilocybin

Subjective Experience Following Psilocybin

University of Calgary

Investigating the Importance of the Subjective Psychedelic Experience
Not Yet Recruiting·Phase 1·MDMA

MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

Lykos Therapeutics

PharmacokineticsHepatic Impairment
Not Yet Recruiting·N/A·ketamine

Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery

Aga Khan University

Breast CancerPain, ChronicPost Surgical Pain
Not Yet Recruiting·Phase 1·ketamine

KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study

Helsinki University Central Hospital

Drug Drug Interaction
Not Yet Recruiting·Phase 4·ketamine

The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

University of Missouri-Columbia

Spine Surgery
Not Yet Recruiting·Early Phase 1·Other

Transition From Acute to Chronic Opioid Use and Chronic Pain

Jacques E. Chelly

Opioid Use Disorder
Not Yet Recruiting·N/A·Other

Comparison Between Two Drugs in Sedation of Upper GI Endoscopy

Zagazig University

Sedation During GI Endoscopy
Not Yet Recruiting·Phase 2·psilocybin

Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder

Centre for Addiction and Mental Health

Major Depressive Disorder (MDD)Alcohol Use Disorder (AUD)
Not Yet Recruiting·Phase 2·psilocybin

Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD

Unity Health Toronto

Post Traumatic Stress DisorderPTSDChronic PTSD
Not Yet Recruiting·Phase 1·psilocybin

A Study of Psychedelics in Healthy Older Adults With Low Well-being

Jennifer Mitchell

Anhedonia in Healthy VolunteersOlder Adults (50-90 Years)
Not Yet Recruiting·Early Phase 1·ketamine

The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.

National and Kapodistrian University of Athens

Opioid-Refractory Chronic Cancer-Related Pain
Not Yet Recruiting·Phase 2·psilocybin

Psilocybin-Assisted Randomized Therapy

Emory University

PTSD
Not Yet Recruiting·Phase 3·Other

Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery

Centre Hospitalier Universitaire, Amiens

Intravenous LidocaineLaparoscopic SurgeryPost Operative Recovery+1 more
Not Yet Recruiting·Phase 2·ketamine

Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.

Fondation Lenval

TraumatologyWounds and InjuryFractures Bone+4 more
Not Yet Recruiting·N/A·Other

Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy

Giresun University

Procedural SedationGastrointestinal Endoscopy
Not Yet Recruiting·Phase 4·ketamine

Ketamine in Central Sensitization

University Hospitals Cleveland Medical Center

EndometriosisChronic Pelvic Pain
Not Yet Recruiting·N/A·ketamine

Effects of Esketamine and Bilateral Lower Limb Elevation on Hemodynamic Stability During Induction of General Anesthesia in Elderly Patients Undergoing Thoracic Surgery

Nanjing First Hospital, Nanjing Medical University

Post Induction Hypotension
Not Yet Recruiting·N/A·ketamine

Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat

Sohag University

Postoperative Sore Throat
Not Yet Recruiting·N/A·Other

Influence of Therapeutic Failure on the Psychosocial Experience in Multiple Sclerosis

University Hospital, Caen

Multiple Sclerosis
Not Yet Recruiting·Early Phase 1·ketamine

Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

University of Pennsylvania

Major Depressive Disorder (MDD)
Not Yet Recruiting·Phase 2·ketamine

Targeting Treatment-Resistant OUD With Ketamine-Assisted Mindfulness Oriented Recovery Enhancement

University of California, San Diego

Opioid Use Disorder
Not Yet Recruiting·Phase 3·ketamine

Optimal Timing of Ketamine Initiation for SCD Pain

Boston Children's Hospital

Sickle Cell DiseaseSickle Cell Crisis
Not Yet Recruiting·Phase 3·ketamine

Ketamine Irrigation Analgesia in Laparoscopic Cholecystectomy

Assiut University

Pain
Not Yet Recruiting·Phase 3·ketamine

Effect of Intravenous Dexmedetomidine and Ketamine on Post-Operative Analgesia

Zagazig University

Postoperative AnalgesiaPostoperative Pain Management
Not Yet Recruiting·N/A·ketamine

Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression

Chinese PLA General Hospital

DepressionAnxietyS-ketamine+1 more
Not Yet Recruiting·N/A·ketamine

Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression

Chinese PLA General Hospital

DepressionAnxietyS-ketamine+1 more
Not Yet Recruiting·Phase 2·psilocybin

Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter

NYU Langone Health

Stuttering
Not Yet Recruiting·Phase 1·psilocybin

Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study

Oregon Health and Science University

Chronic Pelvic Pain
Not Yet Recruiting·Phase 1·ketamine

Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.

Liaquat National Hospital & Medical College

SedationPreoperative Anxiety Experienced by the Pediatric PatientAnxiolytic Effect+1 more
Not Yet Recruiting·Phase 1·Other

Magnesium Sulfate in Pediatric Burn Dressing Changes

Hennepin Healthcare Research Institute

Pediatric Burns
Not Yet Recruiting·N/A·Other

Role of Opioid Free Anaesthesia in Elderly Patients Undergoing Elective Coronary Artery Bypass Graft Surgeries With Cardiopulmonary Bypass in Enhanced Recovery After Surgeries

Ain Shams University

CABGDexmedetomidineKetamine+2 more
Not Yet Recruiting·Phase 1·psilocybin

Psilocybin to Treat Depression in Spinal Cord Injury

James J. Peters Veterans Affairs Medical Center

Spinal Cord InjuryDepression - Major Depressive DisorderVeteran
Not Yet Recruiting·N/A·ketamine

Prospective Study of Induction Medications Used in the Trauma RSI

University of Southern California

TraumaRapid Sequence Intubation
Not Yet Recruiting·Phase 1·psilocybin

Psilocybin for Treatment of OCD-2

Francisco A Moreno

Obsessive - Compulsive Disorder
Not Yet Recruiting·Phase 2·ketamine

Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain

Assiut University

Orofacial Pain
Not Yet Recruiting·Phase 1·ketamine

Effectiveness of Bupivacaine, Ketorolac, Ketamine, vs Bupivacaine Alone in Reducing Postoperative Pocket Pain

Kansas City Heart Rhythm Research Foundation

Pain Management
Not Yet Recruiting·Phase 2·MDMA

MDMA-Assisted Massed Exposure Therapy for PTSD

Emory University

Post Traumatic Stress Disorder
Not Yet Recruiting·Phase 2·ketamine

Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression

University of Rochester

Treatment Resistant Depression (TRD)Chronic Pain
Not Yet Recruiting·Phase 2·psilocybin

Understanding Music and Mindfulness Preferences in Psilocybin-Assisted Psychotherapy

Kyle Greenway

Treatment-Resistant Major Depressive Disorder
Not Yet Recruiting·Phase 3·ketamine

Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain

Tehran University of Medical Sciences

PainDigital Block
Not Yet Recruiting·Phase 1·ketamine

Ketamine Biomarker Validation

Soterix Medical

Treatment Resistant Depression (TRD)
Not Yet Recruiting·N/A·Other

Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2

University Hospital, Clermont-Ferrand

Ischemic StrokeAnterior Cerebral CirculationGeneral Anesthesia+2 more
Not Yet Recruiting·Phase 4·ketamine

Efficacy and Safety of S-ketamine in Elderly Patients Undergoing Non-cardiac Surgery: a RCT(ESSENCE)

Chinese PLA General Hospital

Postoperative Pain
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.