Safety and Efficacy of Lidocaine Versus Ketamine Infusion for Resistant Orofacial Pain

About This Study

A prospective, randomized, double-blind clinical trial comparing the safety and efficacy of intravenous lidocaine, ketamine, and their combination as treatment options for patients suffering from treatment-resistant orofacial pain. The study measures pain reduction primarily using the Visual Analog Scale and evaluates safety and tolerability over a follow-up period of 6 months.

Conditions Studied

Interventions

• •Lidocaine Intravenous Infusion
• •Ketamine intravenous infusion
• •Combined lidocaine and ketamine intravenous infusion

Eligibility

Inclusion Criteria:

\- Adults aged \> 18 years

Resistant orofacial pain patients with failed medical or interventional treatment

Diagnosed with one or more of the following:

Trigeminal neuralgia

Temporomandibular joint (TMJ) dysfunction

Malignant otitis externa

Migraine

Atypical facial pain

Exclusion Criteria:

\- Debilitating cardiac disease

Uncontrolled hypertension

Known allergies to lidocaine or ketamine

Severe renal or hepatic impairment

Pregnancy or breastfeeding

History of substance abuse