Ketamine Irrigation Analgesia in Laparoscopic Cholecystectomy

About This Study

Patients will be assigned randomly to two groups (30 subjects each) to be anesthetized. The study drug will be delivered in opaque bags labeled "study drug" and 60 patients will be allocated in two groups (of 30 patients each) to receive the irrigation at the end of surgery after dissection; irrigation analgesia by 5 ml bupivacaine 0.50% plus 20 ml normal saline (Group N) or 5 ml bupivacaine 0.50% plus 1 mg/kg ketamine (Group K). The volume of irrigation in group K is completed by normal saline to reach a total of 25 ml.

Conditions Studied

Interventions

• •Normal saline
• •Ketamine

Eligibility

Inclusion Criteria:

* Patients with age ≥18 years of ASA I-II who will be scheduled for elective laparoscopic cholecystectomy under general anesthesia.

Exclusion Criteria:

* History of congenital heart disease
* Hypertension
* Developmental delay, or
* Allergy to study drugs