Psilocybin Microdosing on Cognition, Mood and Quality of Life

Inclusion Criteria:

* No history of psychedelic use
* Able to read, speak, and understand English
* Able and willing to provide written informed consent, and willing to commit to study protocol
* Women of childbearing potential must be on a highly effective birth control method

Exclusion Criteria:

* Positive screen for recreational drugs or alcohol on test day will result in rescheduling the appointment
* Current mood, developmental, or psychotic disorders (e.g., schizophrenia, affective disorders) per DSM-V
* Current or past alcohol or substance use disorder per DSM-V
* IQ \<70 on the Weschler Abbreviated Scale of Intelligence
* Serious medical, neuro-ophthalmological, or neurological illness (e.g., cancer, seizure disorders, encephalopathy)
* Current pregnancy, breastfeeding, or ineffective birth control methods
* History of head trauma with loss of consciousness lasting \>30 minutes or concussion in last 30 days
* Any medical/neurological condition that could compromise neurocognitive performance (e.g., epilepsy, multiple sclerosis, fetal alcohol syndrome)
* Anyone deemed unsafe to study personnel for any reason; e.g., suicidal ideation
* Focal brain lesion seen on structural MRI
* MRI contraindications (e.g., implanted metallic object, severe claustrophobia)