Not Yet RecruitingPhase 3ketamine
Comparison of Intranasal Ketorolac and Intranasal Ketamine in Digital Nerve Block Pain
Sponsored by Tehran University of Medical Sciences
NCT ID
NCT07305883
Target Enrollment
64 participants
Start Date
2025-12-28
Est. Completion
2026-08-01
About This Study
This study aims to compare the analgesic effectiveness and side effects of intranasal ketorolac versus intranasal ketamine for reducing pain prior to digital nerve block procedures in patients with finger injuries in emergency department.
Conditions Studied
Interventions
- •Intranasal Ketorolac Tromethamine
- •Intranasal ketamine
Eligibility
Age:18 Years - 65 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * Age: 18-65 years * Weight \> 50 kg * Requires digital nerve block * Able to provide informed consent Exclusion Criteria: * Active peptic ulcer disease (PUD) * History of hypersensitivity to NSAIDs * Pregnancy and breastfeeding * Renal failure * Hepatic failure * Patients who have received analgesics within the past 6 hours * Nasal congestion * Upper respiratory tract infection * Patients with a history of kidney transplantation * Active gastrointestinal bleeding * Systolic blood pressure less than 90 mmHg or greater than 180 mmHg * Heart rate less than 50 per minute or greater than 150 per minute * Concurrent use of NSAIDs or anticoagulant drugs * Inability to provide informed consent * Anatomical abnormalities of the nose or skull base (congenital or acquired) * Hyperreactive airway disease such as severe asthma * Coagulation disorders * Intracranial hemorrhage * Suspected aortic dissection * Suspected rupture of abdominal aortic aneurysm * History of gastrointestinal perforation * Gastrointestinal bleeding within the past month