Comparison of Nebulized Ketamine With Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat

About This Study

The aim of this study is to compare the efficacy of nebulized ketamine versus nebulized magnesium sulfate in reducing the incidence and severity of POST. * Primary outcome • To compare the incidence of POST method. * Secondary outcomes * Onset, Severity, and duration of POST at 0, 2, 4, 6, 12, 24 hours postoperative. * The hemodynamics recording (HR, BP, MBP, pre and post nebulization) * Adverse Effects (e.g., sedation, cough, nausea, vomiting, ….)

Conditions Studied

Interventions

• •Ketamine nebulizer
• •Mg sulfate nebulizer
• •Placebo

Eligibility

Inclusion Criteria:

* Age from 18 to 65 years old.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status I-II.
* Elective surgery requiring GA with endotracheal intubation.

  \- Exclusion Criteria:
* Surgery involves the oral cavity, nasopharynx, larynx, and neck regions.
* Surgery requires prone position.
* Surgery lasted more than 3 hours.
* History of preoperative sore throat, common cold.
* Anticipated difficult airway.
* Any known allergies to study drugs.
* Recent non-steroidal anti-inflammatory drugs use.
* Pregnancy.