Not Yet RecruitingPhase 4ketamine

The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.

NCT ID

NCT07365800

Target Enrollment

248 participants

Start Date

2026-03-02

Est. Completion

2027-06

About This Study

This study will investigate whether a combination of three anesthetic medications will reduce intraoperative and postoperative pain in patients undergoing complex spine surgery, and whether it will reduce the use of opioid pain medication after surgery.

Conditions Studied

Spine Surgery

Interventions

•Methadone-dexmedetomidine-ketamine combination

Eligibility

Age:18 Years - 79 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion criteria:

* Age 18-79 years of age
* Patients undergoing complex spine surgery, defined as 3 or more levels
* English-speaking
* Able to consent for themselves

Exclusion criteria:

* Patients who are unable to consent to study participation in English
* Patients who are unable to consent for themselves.
* Patients with prolonged QT syndrome
* Pregnancy

Additional screening measures:

* Preoperative ECG will be performed in preoperative holding as part of standard of care to assess for prolonged QTc prior to administration of methadone as part of SOC.
* Pregnancy test will be performed as part of SOC on the day of surgery.

Study Locations (1)

University Hospital

Columbia, Missouri, United States