24 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 100 of 2332 trials
Unknown·N/A·LSD
Effect of a Low Starch Diet in Patients With Ankylosing Spondylitis
Universidade do Porto
SpondyloarthritisAnkylosing Spondylitis
Completed·Phase 2·MDMA
MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD
VA Loma Linda Health Care System
Post Traumatic Stress DisorderCombat Stress Disorders
Unknown·N/A·ketamine
Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia
King Saud University
AnemiaCardiomyopathiesPulmonary Hypertension
Completed·N/A·Other
Analgesic Efficacy of US-Guided Interscalene Block Versus Supraclavicular Block for Ambulatory Arthroscopic Rotator Cuff Repair
Ramsay Générale de Santé
Shoulder Lesions
Withdrawn·Phase 4·ketamine
A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn Patients
University of Colorado, Denver
Thermal HyperalgesiaAnxietyPain
Recruiting·N/A·ketamine
Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery
Ain Shams University
Post-spinal HypotensionOrthopedic SurgerySpinal Aneshtesia
Withdrawn·Phase 2·ketamine
Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension Study
Zylorion Health
Treatment Resistant Major Depressive Disorder
Terminated·N/A·Other
Efficacy of Magnetic Resonance-guided High Intensity Focused Ultrasound for the Ablation of Breast Cancer
Kantonsspital Winterthur KSW
Breast Cancer, Invasive Ductal
Completed·Phase 4·Other
Opioid Free Anesthesia and Bariatric Surgery
Northwell Health
Postoperative Quality of Recovery
Withdrawn·Phase 3·ketamine
Endogenous Opioid Modulation by Ketamine
University of Utah
Major Depressive Disorder
Unknown·N/A·ketamine
Effect of Transversus Abdominis Plane Block With Compound Lidocaine and Esketamine on Pain After Surgery
Tianjin Medical University General Hospital
Postoperative Pain
Recruiting·Phase 2·ketamine
Ketamine in Patients Undergoing TEVAR Procedures Receiving NCI
Sam Tyagi
Descending Aortic DissectionPostoperative PainThoracoabdominal Aortic Aneurysm
Completed·N/A·ketamine
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
Yale University
Depression and Suicide
Recruiting·Phase 4·ketamine
The Anaesthetic Ketamine as Treatment for Patients With Severe Acute Brain Injury
Rigshospitalet, Denmark
Subarachnoid Hemorrhage, AneurysmalIntracerebral HemorrhageTraumatic Brain Injury
Completed·Phase 2·ketamine
A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide
Janssen Research & Development, LLC
Major Depressive Disorder
Recruiting·Phase 1·psilocybin
Psilocybin-assisted Treatment for Cannabis Use Disorder
Johns Hopkins University
Cannabis Use Disorder
Active, Not Recruiting·Phase 2·psilocybin
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)
Sheppard Pratt Health System
Treatment Resistant Depression
Completed·Phase 1·ketamine
Ketamine + Mindfulness for Depression
Rebecca Price
Depression, Unipolar
Unknown·Phase 2·psilocybin
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSD
Apex Labs Ltd.
Post-traumatic Stress DisorderDepression
Enrolling by Invitation·Phase 1·psilocybin
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
Johns Hopkins University
PsilocybinMusic Intervention
Active, Not Recruiting·N/A·Other
Pediatric Spinal Muscular Atrophy (SMA) China Registry
Biogen
Muscular Atrophy, Spinal
Recruiting·Phase 1·ketamine
Imaging Neural Correlates of Ketamine Using PET/MR
Medical University of Vienna
Major Depressive Disorder
Unknown·N/A·Other
The Effect of Anesthesia Management on Optic Nerve Sheath Diameter in the Ercp Procedures
Ankara City Hospital Bilkent
Cholangiopancreatography, Endoscopic RetrogradeIntracranial PressureOptic Nerve Sheath Diameter+2 more
Completed·N/A·Other
Impact of OFA During LPV on Postoperative Oxygen Saturation
AZ Sint-Jan AV
Decreased Lung ComplianceOxygen Requirement
Unknown·N/A·LSD
Investigating Lysosomal Storage Diseases in Minority Groups
O & O Alpan LLC
Lysosomal Storage DisordersGaucher DiseaseFabry Disease+2 more
Completed·Early Phase 1·ketamine
The PATHFINDER Study: A Feasibility Trial
Beth Israel Deaconess Medical Center
Coronary Artery DiseaseDelirium
Unknown·N/A·ketamine
Ketamine and Dexmedetomidine Comparative Study
Sohag University
Post Operative Pain
Unknown·Phase 4·ketamine
US-guided SAPB for Rib Fractures in the ED
Andrew A Herring
Rib FracturesRib Fracture Multiple
Not Yet Recruiting·N/A·ketamine
Dexmedetomidine Versus Ketamine as Adjuvants in Bariatric Surgery
Tanta University
ObesityPostoperative PainBariatric Surgery
Completed·Phase 4·ketamine
A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)
Massachusetts General Hospital
Depression
Recruiting·Phase 4·ketamine
Positioning of Esketamine Treatment in the Real-world Management of Depression
Royal North Shore Hospital
Major Depressive Disorder
Recruiting·Phase 3·LSD
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage)
Definium Therapeutics US, Inc.
Generalized Anxiety Disorder
Terminated·N/A·ketamine
Postoperative Pain Protocol Limiting Narcotics for Laparoscopic Hand-assisted Donor Nephrectomy
Stony Brook University
Narcotic UseRenal Transplant Donor of Left Kidney
Completed·Phase 1·ketamine
Ketamine as Adjunctive Analgesic With Bupivacaine in Paravertebral Analgesia for Breast Cancer Surgery
Assiut University
Acute PainChronic Pain
Completed·Early Phase 1·ketamine
Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries
Zagazig University
Agitation, Emergence
Completed·Phase 4·ketamine
Analgesic Effects of Low-dose S-ketamine in Major Spine Fusion Surgery
Peking University First Hospital
S-ketaminePostoperative AnalgesiaSpine Fusion
Unknown·Phase 4·ketamine
The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery
Flavia orange
DeliriumInflammationCognitive Disorders+2 more
Recruiting·Phase 1·psilocybin
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
University College, London
Healthy
Recruiting·Phase 3·ketamine
Use of Iv Tramadol and Ketamine for Prevention of Post Spinal Anesthesia Shivering
Liaquat National Hospital & Medical College
Shivering, Spinal Anesthesia
Completed·Phase 4·ketamine
Baden Prevention and Reduction of Incidence of Postoperative Delirium Trial
University Hospital, Basel, Switzerland
Postoperative Delirium
Completed·Phase 2·ketamine
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
University Hospital, Lille
Depression
Recruiting·N/A·ketamine
Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia
Beijing Tiantan Hospital
Post-anesthesia Recovery
Completed·Early Phase 1·ketamine
Characterizing Clinical and Pharmacological Neuroimaging Biomarkers
Yale University
Cognitive Impairment
Completed·Phase 4·ketamine
Comparison Between Low-dose Ketamine Infusion and Intravenous Morphine
Cairo University
Ketamine
Completed·Phase 4·Other
Milrinone Versus Dobutamine in Critically Ill Patients
Ottawa Heart Institute Research Corporation
Low Cardiac Output SyndromeCardiogenic ShockAcute Coronary Syndrome+1 more
Completed·Phase 3·ketamine
Effect of Opioid Free Anesthetic on Post-Operative Opioid Consumption After Laparoscopic Bariatric Surgery
Christine Oryhan
Opioid Use, UnspecifiedBariatric Surgery CandidateAnesthesia
Completed·Phase 1·psilocybin
Psilocybin-assisted CBT for Depression
University of California, Los Angeles
Major Depressive Disorder
Terminated·Phase 4·ketamine
Ketamine and Refractory Painful Care in a Palliative Unit
Lille Catholic University
Intractable PainIntensive CarePressure Ulcer+1 more
Completed·N/A·ketamine
The Effect of Esketamine on Postoperative Pain Relief in Patients Undergoing Laparoscopic Surgery
General Hospital of Ningxia Medical University
Postoperative Pain
Unknown·Phase 1·Other
Evaluation of the Safety and Efficacy of Esperanza Extract (PA001)
Hospital Universitario San Ignacio
Neoplasm, StomachGastric Neoplasms MalignantPancreatic Neoplasms+6 more
Unknown·N/A·ketamine
Ketamine Infusions for Major Depression Disorder
Sheba Medical Center
Depressive Disorder, Major
Completed·Phase 2·ketamine
A Study of the Efficacy and Safety of Amitriptyline/Ketamine Topical Cream in Patients With Diabetic Peripheral Neuropathy
EpiCept Corporation
Diabetic Peripheral NeuropathyNeuralgia
Completed·Phase 3·DMT
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
Genentech, Inc.
Multiple Sclerosis, Relapsing-Remitting
Recruiting·Phase 2·psilocybin
Does Psilocybin Require Psychedelic Effects to Treat Depression?
Centre for Addiction and Mental Health
Treatment-resistant Depression
Not Yet Recruiting·Phase 4·ketamine
An Exploratory Study of the Efficacy and Safety of Esketamine and Dexmedetomidine in Non-Intubated ICU Patients With Hyperactive Delirium
The First Affiliated Hospital with Nanjing Medical University
DexmedetomidineKetamineAnalgesia+4 more
Completed·Phase 4·ketamine
Nalbuphine Versus Ketamine for Prevention of Emergence Agitation After Sevoflurane in Children Undergoing Tonsillectomy
Ain Shams University
Pediatric ALLPediatric Anesthesia
Completed·N/A·ketamine
Ketamine Anesthesia in Electroconvulsive Therapy
Mayo Clinic
Depression
Unknown·Phase 4·ketamine
Effect of Esketamine on Abdominal Pain During TACE-HAIC in Patients With Hepatocellular Carcinoma
The Second Affiliated Hospital of Chongqing Medical University
Hepatocellular CarcinomaTransarterial ChemoembolizationHepatic Arterial Infusion Chemotherapy+1 more
Unknown·Phase 1·ketamine
Study of Ketamine as an Antidepressant in Major Depressive Disorder
Shi Jinyun
Major Depressive Disorder
Completed·N/A·ketamine
Evaluation of a New Protocol for Adult Procedural Sedation With Ketamine-propofol in a 1 on 4 Ratio
University Hospital, Ghent
Procedural Sedation and Analgesia
Completed·Phase 1·ketamine
Study to Assess the Effects of Esketamine on Safety of On-road Driving in Healthy Participants
Janssen Research & Development, LLC
Healthy
Completed·Phase 4·ketamine
A Prospective, Multi-center, Randomized Controlled Study of Muscle Relaxation Effect and Safety of Mivacurium Chloride in Pediatric Surgery Patients
Jiangsu Nhwa Pharmaceutical Co., Ltd.
Efficacy and Safety of Mivacurium Chloride for Pediatric Patients
Active, Not Recruiting·N/A·ibogaine
Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure
Stanford University
Blast or Combat ExposureHead Injury Trauma
Withdrawn·Phase 1·psilocybin
Bioavailability Study of Psilocybin in Normal Adults
University of Wisconsin, Madison
Healthy
Completed·Phase 4·ketamine
Ketamine for Older Adults Pilot
Washington University School of Medicine
Treatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more
Unknown·Phase 4·ketamine
Effect of Perioperative Low Dose Ketamine on Postoperative Recovery in Patients Undergoing Breast Cancer Surgery
Han Yuan
Breast Cancer
Completed·N/A·Other
Patient Doctor Lies
University of Utah
Patient LyingPrivacy StatementsRisk Statements+2 more
Recruiting·Phase 2·psilocybin
Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study
McMaster University
Cannabis Use Disorder, ModerateCannabis Use Disorder, Severe
Not Yet Recruiting·Early Phase 1·ketamine
Ketamine and Lidocaine Infusion in Refractory Chronic Migraine
Assiut University
Refractory Chronic Migraine
Unknown·Early Phase 1·psilocybin
A Community of Practice Program With Psilocybin-assisted Therapy for End-of-Life Patients
The Roots to Thrive Society for Psychedelic Therapy
End of Life
Recruiting·N/A·ketamine
Effect of Esketamine on Conscious State in Patients With pDoC
Beijing Tiantan Hospital
EsketamineConsciousness Disorders
Completed·Phase 1·ketamine
Biomarkers of Fast Acting Therapies in Major Depression
University of California, Los Angeles
Major Depressive Disorder
Recruiting·N/A·ketamine
Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life
Albany Research Institute, Inc.
Depression
Completed·Phase 1·ketamine
Ketamine and Prolonged Exposure in PTSD
Minneapolis Veterans Affairs Medical Center
Post-traumatic Stress Disorder
Completed·Phase 1·ketamine
Study of SAGE-904 Using a Ketamine Challenge to Evaluate Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy Participants
Supernus Pharmaceuticals, Inc.
Healthy Volunteer
Completed·N/A·Other
Characteristics, Adherence, and Persistence Among Multiple Sclerosis Patients Treated With Disease-Modifying Therapies
Novartis
Multiple Sclerosis
Completed·Phase 4·ketamine
Prevention of N-methyl-D-aspartate (NMDA) Antagonist-induced Psychosis in Kids
Washington University School of Medicine
Psychoses, Substance-Induced
Not Yet Recruiting·Phase 4·ketamine
Esketamine Versus Crisis Response Planning Versus Optimized Treatment as Usual for Suicide Prevention: A Pragmatic Controlled Trial in Two Brazilian Cities
University of Sao Paulo
Suicide PreventionKetamineCrisis Response Plan
Unknown·N/A·Other
Effect of Opioid Free Versus Opioid-Based Anesthesia on Cerebral Oximetry In Gastric Sleeve Operation
Tanta University
Bariatric Surgery Candidate
Terminated·Phase 3·ketamine
Intranasal Ketamine for Pain Control in Patients with Sickle Cell Disease and Vaso-occlusive Episode (VOE) in the PED
Abigail Nixon
Sickle Cell DiseaseVaso-Occlusive Pain Episode in Sickle Cell DiseaseVaso-occlusive Crisis+3 more
Terminated·N/A·Other
Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2)-Related Multiple Sclerosis (MS) Vaccination Study
Biogen
Multiple Sclerosis (MS)
Completed·Phase 2·psilocybin
Safety and Efficacy of Psilocybin for Body Dysmorphic Disorder
New York State Psychiatric Institute
Body Dysmorphic Disorders
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Not Yet Recruiting·Phase 4·ketamine
Feasibility of Closed-loop TCI Based on New EEG Baseline in the Presence of Low Dose of Esketamine
bo xu
General Anesthesia With PropofolClosed-Loop
Completed·Phase 3·ketamine
The Efficacy and Safety of Esketamine in Elective Laparoscopic Surgery
Chengdu Brilliant Pharmaceutical Co., Ltd.
LaparoscopyAnesthesia, Intravenous
Withdrawn·Phase 3·ketamine
Effectiveness of Ketamine in Malignant Neuropathic Pain Relief
Haukeland University Hospital
Pain, Intractable
Completed·Phase 1·ketamine
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
Yale University
Depressive Disorder, MajorPost Traumatic Stress DisorderBipolar Disorder
Completed·N/A·ketamine
Intraoperative Ketamine and Magnesium Therapy for Control of Postoperative Pain After a Liposuction and Lipoabdominoplasty
University of Chile
Pain, Postoperative
Recruiting·N/A·Other
Evaluation of the Effectiveness of the Administration of Local Anesthetics Via Two Catheters Placed During Surgery, and Study of the Benefits on Respiratory Function and Therefore on Recovery Time
CHU de Reims
Duration of Hospitalization in Intensive Care Unit
Completed·Phase 2·LSD
Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related Anxiety
Multidisciplinary Association for Psychedelic Studies
Anxiety
Unknown·N/A·ketamine
Median Effective Dose of Esketamine Pretreatment to Prevent Sufentanil-induced Cough
Yangzhou University
SufentanilEsketamine
Not Yet Recruiting·N/A·Other
Ketodex Versus Ketofol in Adolescent Gastrointestinal Endoscopy
Giresun University
Procedural SedationGastrointestinal Endoscopy
Recruiting·Phase 1·psilocybin
Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence
University of Colorado, Denver
Breast CancerOvarian Cancer
Completed·N/A·LSD
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers
Psychiatric University Hospital, Zurich
Healthy
Recruiting·N/A·ketamine
Methods of Post Operative Analgesia in Patients Undergoing Thyroidectomy
Sohag University
Thyroid Disorder
Unknown·N/A·Other
A Comparative Study Between Analgesic Effect of Opioid Free and Opioid Based Anesthesia in Radical Nephrectomy Surgery
Kasr El Aini Hospital
Opioid Free Anesthesia
Unknown·Phase 4·ketamine
Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia
Hallym University Kangnam Sacred Heart Hospital
Cholecystitis
Completed·N/A·Other
Outcome of Multimodal Anesthesia Bern
Insel Gruppe AG, University Hospital Bern
Opioid UsePain, PostoperativePostoperative Complications+1 more
Completed·N/A·ketamine
Dexmedetomidine-esketamine for Percutaneous Radiofrequency Liver Ablation
Peking University First Hospital
Liver CancerRadiofrequency AblationEsketamine+1 more
Completed·N/A·ketamine
Effects of Ketamine and Propofol in Otoacoustic Emissions (OAE) in Children
Istanbul University
Normal Healthy EarsKetamine and Propofol Effects on HemodynamicsKetamine and Propofol Effects on TEOAE and DPOAE
More trials available. Refine your search to see specific results.
How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.