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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 241288 of 1013 trials
Completed·Phase 4·ketamine

Methadone and Ketamine for Spinal Surgery

Endeavor Health

Pain
Completed·N/A·ketamine

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Vanderbilt University

Postoperative Nausea and Vomiting
Completed·Phase 3·ketamine

A Long-term Safety Study of Esketamine Nasal Spray in Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial

University of Texas Southwestern Medical Center

Cardiopulmonary ArrestRespiratory Arrest
Completed·Phase 2·ketamine

Adjuvant Low-dose Ketamine in Pediatric Sickle Cell Vaso-occlusive Crisis

UCSF Benioff Children's Hospital Oakland

Sickle Cell DiseaseVaso-Occlusive Crisis
Completed·Phase 1·ketamine

Dexmedetomidine and Ketamine in MRI

Children's Hospital Medical Center, Cincinnati

Magnetic Resonance Imaging
Completed·Phase 4·ketamine

Sedation Methods During Cataract Surgery

Wake Forest University Health Sciences

PhacoemulsificationCataract
Completed·Phase 2·ketamine

Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

VA Connecticut Healthcare System

Major Depressive DisorderAlcohol Use Disorder
Completed·Phase 3·ketamine

"THINK Trial: Treatment of Headache With IntraNasal Ketamine: A Randomized Controlled Trial Evaluating the Efficacy of Intranasal Ketamine Versus Standard Therapy in the Management of Primary Headache Syndromes in the Emergency Department"

Brooke Army Medical Center

HeadacheIntranasal Ketamine
Completed·Phase 2·ketamine

CAP-Ketamine for Antidepressant Resistant PTSD

VA Office of Research and Development

PTSDPosttraumatic Stress Disorder
Completed·Phase 4·ketamine

Clinical Trial to Examine Individual Pain Tolerance in the Use of Two Anesthetic Techniques to Perform Saturation Prostate Biopsy

Complexo Hospitalario Universitario de A Coruña

Prostatic Cancer
Completed·Phase 4·ketamine

Geriatric Ketamine for Pain Management Study

Antonios Likourezos

Pain
Completed·N/A·ketamine

Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia

Washington University School of Medicine

DepressionDeliriumSeizures+1 more
Completed·Phase 3·ketamine

Pain Reduction With Intranasal Medications for Extremity Injuries

Children's Hospital Medical Center, Cincinnati

PainTraumatic Limb Injury
Completed·Phase 1·ketamine

Crossover Study to Evaluate the Abuse Potential of Intranasal Esketamine Compared to Racemic Intravenous Ketamine in Nondependent, Recreational Drug Users

Janssen Research & Development, LLC

Drug Abuse
Completed·Phase 4·ketamine

The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine

University Medical Center of Southern Nevada

Headache
Completed·Phase 2·ketamine

Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects

Yale University

Depression
Completed·Phase 1·ketamine

A Mass Balance Study With a Microtracer Dose of 14C-esketamine in Healthy Male Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 4·ketamine

Ketamine for Depression: An MRI Study

Massachusetts General Hospital

DepressionAnxious DepressionMajor Depressive Disorder
Completed·N/A·ketamine

Ketamine Anesthesia for Improvement of Depression in ECT

VA Puget Sound Health Care System

Major Depressive Disorder
Completed·Phase 1·ketamine

Pharmacokinetic, Safety, and Tolerability Study of Intranasally Administered Esketamine in Healthy Han Chinese, Korean, Japanese, and Caucasian Participants and the Effects of Rifampin on the Pharmacokinetics of Intranasally Administered Esketamine

Janssen Research & Development, LLC

Healthy
Completed·N/A·ketamine

Ketamine for Acute Migraine in the Emergency Department

Carilion Clinic

Headache
Completed·Phase 2·ketamine

Ketamine Infusion in Neurologic Deficit

Unity Health Toronto

Subarachnoid Hemorrhage
Completed·Phase 3·ketamine

Intranasal Versus Intravenous Ketamine for Procedural Sedation in Children

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Bone Fractures
Completed·Early Phase 1·ketamine

Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.

Sunnybrook Health Sciences Centre

Major Depressive DisorderBipolar I DisorderBipolar II Disorder+2 more
Completed·Phase 4·ketamine

The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)

University of Turku

AnesthesiaUnconsciousness
Completed·Phase 1·ketamine

Study of Intranasal Ketamine for Social Impairment in Autism Spectrum Disorder

Children's Hospital Medical Center, Cincinnati

Autism Spectrum Disorder
Completed·Phase 1·ketamine

A Study to Assess the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Janssen Research & Development, LLC

Renal ImpairmentHealthy
Completed·Phase 2·ketamine

IN Sub-Dissociative Ketamine vs IN Fentanyl

Wake Forest University Health Sciences

Bone Fracture
Completed·Phase 1·ketamine

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Janssen Research & Development, LLC

Hepatic ImpairmentNormal Hepatic Function
Completed·Phase 1·ketamine

Memory Modulation by Pain During Anesthesia

University of Pittsburgh

AmnesiaPainAnesthesia
Completed·N/A·ketamine

Effect of Single Dose Ketamine and Magnesium on Postoperative Pain in Patients Undergoing Bariatric Surgery

Milton S. Hershey Medical Center

Obesity
Completed·Phase 3·ketamine

Ketamine for Treatment Resistant Late-Life Depression

VA Office of Research and Development

Treatment Resistant Depressive Disorder
Completed·Phase 3·ketamine

A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy

University of Alberta

Depressive Disorder
Completed·Phase 2·ketamine

intrathecaم Ketamine, Morphine and Both for Lower Abdominal Cancer Surgery Pain

Assiut University

Postoperative Pain
Completed·Phase 1·ketamine

Pharmacokinetic Study of Intranasal Esketamine and Its Effects on the Pharmacokinetics of Orally-Administered Midazolam and Bupropion in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 4·ketamine

Ketamine Infusion for Adolescent Depression and Anxiety

Yale University

Major Depressive DisorderAnxiety Disorder
Completed·Phase 3·ketamine

A Long-term, Safety and Efficacy Study of Intranasal Esketamine in Treatment-resistant Depression

Janssen Research & Development, LLC

Treatment-resistant Depression
Completed·Phase 2·ketamine

The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction

Mayo Clinic

Cognitive DisordersDeliriumAcute Kidney Injury
Completed·Phase 4·ketamine

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

Medical College of Wisconsin

Wounds and InjuriesRib Fractures
Completed·Phase 3·ketamine

A Study to Evaluate the Efficacy, Safety, and Tolerability of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 3·ketamine

A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Treatment-resistant Depression
Completed·Phase 3·ketamine

A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Treatment-resistant Depression
Completed·Phase 2·ketamine

Local Ketamine Instillation for Postoperative Analgesia

Assiut University

Postoperative Pain
Completed·N/A·ketamine

Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression

The Cleveland Clinic

Treatment Resistant DepressionMajor Depressive DisorderSevere Depression
Completed·Phase 1·ketamine

Spreading Depolarization and Ketamine Suppression

University of New Mexico

Cortical Spreading DepolarizationCortical Spreading DepressionSubarachoid Hemorrhage+1 more
Completed·N/A·ketamine

Prospective Analgesic Compound Efficacy (PACE) Study

Express Specialty Pharmacy

ArthritisTendonitisGout+5 more
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.