CompletedPhase 4ketamine

Ketamine Infusion Therapy for the Management of Acute Pain in Adult Rib Fracture Patients

NCT ID

NCT02432456

Target Enrollment

153 participants

Start Date

2015-09

Est. Completion

2018-08

About This Study

This study will evaluate the effectiveness of ketamine infusions in the management of acute pain resulting from broken ribs suffered following a blunt trauma. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.

Conditions Studied

Wounds and InjuriesRib Fractures

Interventions

•Ketamine
•Placebo
•Intercostal Nerve Block
•Acetaminophen
•Ibuprofen
•Pantoprazole
•Methocarbamol
•Opioid

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

1. age greater than 18 years
2. rib fractures following recent trauma with admission to Froedtert Memorial Lutheran Hospital

Exclusion Criteria:

1. history of adverse reaction / intolerance to ketamine therapy
2. elevated intracranial pressure
3. ischemic heart disease defined as active acute coronary syndrome
4. severe, poorly controlled hypertension (Systolic Blood Pressure \> 200 mmHg or Diastolic Blood Pressure \> 100 mmHg)
5. current opiate agonist/antagonist therapy
6. concurrent use of monoamine oxidase inhibitors (MAOIs)
7. chronic pain or opioid tolerance defined as \> 3 weeks of \>30mg oral morphine equivalents per day
8. current substance abuse with opiates (prescription and/or heroin) or ketamine
9. Glasgow Coma Scale \<13
10. Intubation on arrival or need for urgent intubation on arrival
11. inability to delineate pain and/or appropriately communicate with staff
12. history of psychosis
13. three or more psychotropic medications
14. active delirium
15. glaucoma
16. pregnancy
17. prisoners

Study Locations (1)

Froedtert Memorial Lutheran Hospital

Milwaukee, Wisconsin, United States