CompletedPhase 1ketamine

Spreading Depolarization and Ketamine Suppression

NCT ID

NCT02501941

Target Enrollment

10 participants

Start Date

2015-07

Est. Completion

2017-05-01

About This Study

Hypothesis: Cortical spreading depolarizations are inhibited by the NMDA receptor antagonist Ketamine Aim 1: To demonstrate, in a group of patients with acute severe brain injury requiring surgery including traumatic brain injury and aneurysmal subarachnoid hemorrhage, whether use of continuous infusion of ketamine decreases frequency of occurrence of cortical spreading depolarizations.

Conditions Studied

Cortical Spreading DepolarizationCortical Spreading DepressionSubarachoid HemorrhageTraumatic Brain Injury

Interventions

•ketamine

Eligibility

Age:18 Years - 90 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* GCS \<8
* SAH or severe traumatic brain injury requiring craniotomy
* Consent obtainable (via legal representative)
* Ictus (bleed or injury) within 48 hours of enrollment
* Clinically appropriate for multimodality monitoring

Exclusion Criteria:

* Anticipated survival \<48 hours
* No craniotomy
* Infratentorial craniotomy only•Unable to obtain consent
* Absence of clinically used multimodality monitoring
* Prisoners
* Pregnant

Study Locations (1)

University of New Mexico

Albuquerque, New Mexico, United States