A Study to Assess the Effects of Renal Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Inclusion Criteria:

* Signed an informed consent document indicating they understand the purpose of and procedures required for the study and are willing to participate in the study
* For women of childbearing potential, must have a negative serum beta-human chorionic gonadotropin (beta-hCG) pregnancy test at Screening; and a negative urine pregnancy test on Day minus (-) 1
* Comfortable with self-administration of intranasal medication and able to follow instructions provided
* Hemoglobin concentration of greater than or equal to (\>=) 10 grams per deciLiter (g/dL) (Only for cohorts 1, 2, and 3)
* Platelet count of \>= 50,000 counts/microliter (Only for cohorts 1, 2, and 3)

Exclusion Criteria:

* Current or previous diagnosis of psychotic or major depressive disorder (MDD) with psychosis, bipolar or related disorder, intellectual disability, borderline personality disorder, or antisocial personality disorder
* A lifetime history of cerebrovascular disease including stroke or transient ischemic attack, aneurysmal vascular disease
* Unstable coronary artery disease or myocardial infarction in the last 12 months or any unstable angina requiring revascularization procedure, hemodynamically significant valvular heart disease, or New York Heart Association Class III-IV heart failure
* Has had a renal transplant or diagnosis of systemic lupus erythromatosus or renal carcinoma
* Has a nasal piercing
* Participant requires dialysis (Only for cohorts 1, 2, and 3)