CompletedPhase 4ketamine
The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine
Sponsored by University Medical Center of Southern Nevada
NCT ID
NCT02657031
Target Enrollment
54 participants
Start Date
2016-03-17
Est. Completion
2017-03-21
About This Study
This study compares the efficacy of low dose Ketamine versus Compazine for the control of headache in patients presenting to the Emergency Department.
Conditions Studied
Interventions
- •Prochlorperazine
- •Ketamine
- •Diphenhydramine
- •Ondansetron
- •Normal Saline
Eligibility
Age:18 Years - 65 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * Age 18 to 65 years * Temperature \< 100.4° F * Diastolic Blood Pressure \<104 mm Hg * Normal neurological exam and mormal mental status Exclusion Criteria: * Pregnant or breastfeeding. * Meningeal signs are present * Acute angle closure glaucoma is suspected. * Head trauma within the previous two weeks * Lumbar puncture within the previous two weeks * Thunderclap onset of the headache * Weight more than 150 kg or less than 40 kg. * Known allergy to one of the study drugs. * History of schizophrenia or bipolar disorder. * History of intracranial hypertension. * Is a prisoner * Patient declined informed consent * Non-English speaking patient. * Attending provider excludes patient
Study Locations (1)
University Medical Center of Southern Nevada
Las Vegas, Nevada, United States