Memory Modulation by Pain During Anesthesia

About This Study

The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics. The ability to identify previously presented words from a list assessed the degree of memory formation. In a subset of subjects, functional magnetic resonance imaging was used to identify the neural correlates of memory inhibition or facilitation by the combination of pain and anesthetic used.

Conditions Studied

Interventions

• •Dexmedetomidine
• •Midazolam
• •Peripheral nerve stimulation
• •Ketamine

Eligibility

Inclusion Criteria:

* Healthy adult volunteers, with normal memory and hearing, whose native language is English

Exclusion Criteria:

* pregnancy
* significant memory or hearing loss
* sleep apnea
* chronic pain
* metal or electronic implants
* claustrophobia
* Currently taking: antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, sleep-aids, or pain medication

Study Locations (1)