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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 97144 of 1013 trials
Completed·Phase 2·ketamine

Ketamine for the Treatment of Opioid Use Disorder and Depression

Medical University of South Carolina

DepressionOpioid-use DisorderOpioid Abuse
Completed·Phase 2·ketamine

A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide

Seelos Therapeutics, Inc.

Depressive Disorder, MajorSuicidal
Completed·Phase 1·ketamine

Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine

Melt Pharmaceuticals

Procedural Sedation
Completed·Phase 1·ketamine

A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine

Boehringer Ingelheim

Healthy
Completed·Phase 3·ketamine

The Ketamine for Acute Postoperative Analgesia (KAPA) Trial

University Health Network, Toronto

Postoperative Pain
Completed·Phase 3·ketamine

Ketamine to Prevent PPD After Cesarean

Washington University School of Medicine

Postpartum Depression
Completed·Phase 4·ketamine

A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

Ketamine for Older Adults Pilot

Washington University School of Medicine

Treatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more
Completed·Phase 4·ketamine

Ketamine Treatment Effects on Synaptic Plasticity in Depression

New York State Psychiatric Institute

Major Depressive Disorder
Completed·Early Phase 1·ketamine

Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty

Dartmouth-Hitchcock Medical Center

Pain, PostoperativeArthroplasty Complications
Completed·N/A·ketamine

Efficacy of Ketamine in Post Anesthesia Recovery Room

University of Alberta

Pain, PostoperativeKetamine Adverse ReactionPain, Refractory+2 more
Completed·Phase 3·ketamine

A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder

Janssen-Cilag International NV

Depressive Disorder, Major
Completed·Phase 1·ketamine

Low-Dose Ketamine in Children With ADNP Syndrome

Alexander Kolevzon

ADNP Syndrome
Completed·N/A·ketamine

Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression

Mclean Hospital

Major Depressive Disorder
Completed·Phase 1·ketamine

Phase 1 Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual) and IV Midazolam or Ketamine

Melt Pharmaceuticals

Healthy Volunteers
Completed·Phase 4·ketamine

Ketamine for Acute Pain Management After Trauma

The University of Texas Health Science Center, Houston

Trauma InjuryPainOpioid Use
Completed·Phase 4·ketamine

Low Dose Ketamine and Acute Pain Crisis

Rhode Island Hospital

Sickle Cell Crisis
Completed·Phase 2·ketamine

Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric Surgery

University Hospital of Split

Surgical Procedure, Unspecified
Completed·Phase 1·ketamine

A Study of Different Oral Thin Film (S)-Ketamine Formulations for Sublingual Administration in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 4·ketamine

A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health

Field Trip Health

DepressionAnxietyPost Traumatic Stress Disorder
Completed·N/A·ketamine

Ketamine-Induced Brain Changes and Their Modulation by Lamotrigine

Charite University, Berlin, Germany

Emotions
Completed·Phase 1·ketamine

A Study of Sublingually Administered (S)-Ketamine Oral Solution in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 4·ketamine

Opioid Free vs Opioid Based Anesthesia for Laparoscopic Sleeve Gastrectomy

Medical University of Warsaw

ObesityPostoperative PainPostoperative Nausea+2 more
Completed·N/A·ketamine

Ketamine Infusion as Sedative Analgesic in Severe ARDS

Interfaith Medical Center

Intensive Care Unit SyndromeMechanical Ventilation ComplicationSedatives and Hypnotics Causing Adverse Effects in Therapeutic Use+1 more
Completed·Phase 3·ketamine

Effect of Opioid Free Anesthetic on Post-Operative Opioid Consumption After Laparoscopic Bariatric Surgery

Christine Oryhan

Opioid Use, UnspecifiedBariatric Surgery CandidateAnesthesia
Completed·Early Phase 1·ketamine

The Pharmacokinetics of Ketamine in the Breast Milk of Lactating Women

The Ketamine Research Foundation

KetamineLactation
Completed·N/A·ketamine

Patient Satisfaction With Subdissociative Dose Ketamine Versus Morphine for Emergency Department Pain Control

CHRISTUS Health

Abdominal Pain
Completed·N/A·ketamine

A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders

Medical University of Gdansk

Treatment Resistant DepressionBipolar DepressionKetamine+1 more
Completed·N/A·ketamine

Chart Review of Patients Undergoing Ketamine Infusions

Brain and Cognition Discovery Foundation

Major Depressive DisorderBipolar DisorderObsessive-Compulsive Disorder+1 more
Completed·Phase 1·ketamine

Effect of Ketamine Intranasal Spray in Treatment of Chronic Cluster Headache

CCH Pharmaceuticals

Cluster Headache
Completed·Phase 4·ketamine

Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department

MercyOne Des Moines Medical Center

DepressionDepression SevereDepression Acute+2 more
Completed·Phase 2·ketamine

Ketamine to Improve Recovery After Cesarean Delivery - Part 1

Grace Lim, MD, MS

Obstetric PainPostpartum DepressionBreastfeeding+5 more
Completed·Early Phase 1·ketamine

EEG Characteristics in ECT

University of New Mexico

Electroconvulsive TherapyDirect Current ElectroencephalogramKetamine+1 more
Completed·Phase 1·ketamine

Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

University of Minnesota

Post-Traumatic Stress DisordersMajor Depressive Disorder
Completed·Phase 1·ketamine

THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis

Yale University

CannabisKetamine
Completed·Phase 2·ketamine

A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO Study

Clexio Biosciences Ltd.

Adjunctive Treatment of Major Depressive Disorder
Completed·Phase 3·ketamine

Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy

University of Patras

Lung DiseasesDiagnosisAnesthesia
Completed·Phase 2·ketamine

Investigation of the NMDA Antagonist Ketamine as a Treatment for Tinnitus

New York State Psychiatric Institute

Tinnitus
Completed·Phase 4·ketamine

Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery

Stanford University

Major Depressive DisorderSurgeryOrthopedic Disorder
Completed·Early Phase 1·ketamine

The PATHFINDER Study: A Feasibility Trial

Beth Israel Deaconess Medical Center

Coronary Artery DiseaseDelirium
Completed·N/A·ketamine

Stanford Regulating Circuits of the Brain Study- Ketamine

Stanford University

Healthy
Completed·Phase 2·ketamine

Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects

Icahn School of Medicine at Mount Sinai

Healthy Volunteers
Completed·Phase 2·ketamine

A Pilot Study: a Non-opioid Technique for Postoperative Adenoidectomy Pain Relief in Pediatric Patients

Arlyne Thung

Adenoid Hypertrophy
Completed·Phase 4·ketamine

Use of Ketamine for Conscious Sedation in Flexible Bronchoscopy

Brooke Army Medical Center

Conscious SedationPatient SatisfactionKetamine
Completed·Phase 2·ketamine

Biomarkers of Response to Ketamine in Depression: MRI and Blood Assays Before and After Open Label Intranasal Ketamine

Dan Iosifescu

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

Effects of Ketamine on Mentalizing and Metacognition in Healthy Volunteers

University Hospital, Bonn

Ketamine-Induced Psychotic DisorderSocial CognitionTheory of Mind
Completed·Phase 1·ketamine

The Effects of Sedatives on Tobacco Use Disorder

Wake Forest University Health Sciences

Tobacco Use Disorder
Completed·N/A·ketamine

Impact of Pre-Sedation Virtual Reality Game on Post-Discharge Negative Behaviors in the Pediatric Emergency Department

Medical College of Wisconsin

Behavior, ChildAnxiety
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.