CompletedEarly Phase 1ketamine

EEG Characteristics in ECT

NCT ID

NCT04022226

Target Enrollment

11 participants

Start Date

2019-10-01

Est. Completion

2020-10-01

About This Study

The investigators will be examining slow-wave characteristics in depressed patients receiving electroconvulsive therapy (ECT) using direct current electroencephalogram (dcEEG) by anesthesia induction agent.

Conditions Studied

Electroconvulsive TherapyDirect Current ElectroencephalogramKetamineSpreadind Depression

Interventions

•Ketamine
•Methohexital

Eligibility

Age:18 Years - 65 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Structured Clinical Interview for DSM-5 will confirm diagnosis of MDD or BPD-depressed (with or without psychotic features
* The clinical indications for ECT including treatment resistance or a need for a rapid and definitive response;
* Hamilton Depression Rating Scale 24-item (HDRS-24) \> 21; and
* Age range between 18 and 65 years of age.

Exclusion Criteria:

* Defined neurological or neurodegenerative disorder (e.g., history of head injury with loss of consciousness \> 5 minutes, epilepsy, Alzheimer's disease);
* Other psychiatric conditions (e.g., schizophrenia, schizoaffective disorder, bipolar disorder)
* Current drug or alcohol use disorder, except for nicotine and marijuana
* Adults unable to consent, pregnant women, prisoner
* Non-English speakers
* Patients that cannot tolerate Methohexital and Ketamine.

Study Locations (1)

University of New Mexico Mental Health Center