CompletedEarly Phase 1ketamine

Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty

NCT ID

NCT04437888

Target Enrollment

200 participants

Start Date

2020-09-14

Est. Completion

2024-06-01

About This Study

Prospective randomized double blinded, placebo controlled study that will evaluate the effect of intra-operative ketamine administration on post-operative analgesic requirements and self-reported pain in patients undergoing total hip and total knee arthroplasty who demonstrate high levels of pain catastrophizing.

Conditions Studied

Pain, PostoperativeArthroplasty Complications

Interventions

•Ketamine

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

• Adults, 18 years and older, undergoing primary total hip arthroplasty or total knee arthroplasty

Exclusion Criteria:

* History of intolerance or allergy to ketamine, either documented or self-reported.
* History of increased intra-ocular pressure, uncontrolled hypertension, increased intra-cranial pressure, psychosis.
* Unable to provide consent.
* Current incarceration.
* Pregnant or breast feeding

Study Locations (1)

Dartmouth-Hitchcock

Lebanon, New Hampshire, United States