CompletedPhase 1ketamine

The Effects of Sedatives on Tobacco Use Disorder

Sponsored by Wake Forest University Health Sciences

NCT ID
NCT03813121
Target Enrollment
10 participants
Start Date
2019-06-01
Est. Completion
2021-08-31

About This Study

This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.

Conditions Studied

Tobacco Use Disorder

Interventions

  • •midazolam intravenous infusion
  • •placebo intravenous infusion
  • •ketamine intravenous infusion

Eligibility

Age:18 Years - 55 Years
Healthy Volunteers:Yes
View full eligibility criteria
Inclusion Criteria:

* smoke at least 5 cigarettes per day
* smoked at least 2 years
* negative urine drug screen for psychoactive drugs and negative breath alcohol concentration
* live in Little Rock AR or surrounding area

Exclusion Criteria:

* unstable or stable medical condition that would interact with study medication or participation
* serious head trauma or neurological disorder
* hypertension, abnormal ECG or metabolic blood results
* meet criteria for psychosis, schizophrenia, major depressive disorder, or bipolar disorder
* use of psychoactive drugs or medications
* BMI \> 40
* among women, pregnancy or breastfeeding

Study Locations (1)

University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States

This trial is not recruiting

This study has completed enrollment. Check back for results or find similar trials.

Find recruiting trials
Data Source
ClinicalTrials.gov

Last updated from source

The Effects of Sedatives on Tobacco Use Disorder | Huxley