A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health

Inclusion Criteria:

* Written informed consent
* Over the age of 18
* Should be psychologically and medically cleared by a psychiatrist, family physician, or treatment team
* Diagnosed with Major Depressive Disorder (MDD), Bipolar Depression, Generalized Anxiety Disorder, Obsessive Compulsive Disorder (OCD), and Eating Disorder by a licensed healthcare practitioner (including Field Trip Consultants)
* A significant history of trauma and/or formal diagnosis of PTSD as per the Diagnostic and Statistical Manual of Mental Disorders 5 (DSM 5)
* Individuals who have received Electroconvulsive Therapy (ECT) or other neuromodulatory treatments like Transcranial Magnetic Stimulation (TMS)
* Individuals reporting suicidal ideation may be included, as suicidal ideation is a symptom of a Major Depressive Episode (MDE)

Exclusion Criteria:

* Individuals who are unable to consent to the treatment
* Pregnant women and nursing mothers

  --Note that Post Partum Depression (PPD) can be considered on a case-by-case basis in consultation with the National Medical Director.
* There is a relative (not absolute) contraindication for individuals with a Body Mass Index (BMI) of above 35. These clients must be given thorough consideration by the medical team.
* Any individual who has met DSM 5 criteria for a Substance Use Disorder in the past 3 months.

  * Note that patients with alcohol, opioid, benzodiazepine, cocaine, and amphetamine use disorders need to go through detox (for alcohol/benzodiazepines) and be sober for 4 weeks.
  * Note that mild active alcohol, cocaine, and cannabis use can be considered on a case-by-case basis at the comfort level of the treatment team if the client has demonstrated abstaining or significant reduction of use prior to starting treatment.
* Daily use of moderate to high doses of benzodiazepines
* Individuals who are experiencing psychotic symptoms as part of an MDE (mood congruent/ mood incongruent)
* Psychosis: Schizophrenia, Schizoaffective disorder, Bipolar 1 with psychotic features during mania
* Active Mania: Bipolar 1 (chronic non-disruptive hypomania is an exception at the discretion of the consultant)
* Borderline Personality Disorder
* Uncontrolled medical disorders
* Physical conditions with negative interaction with ketamine (e.g., metabolic blood disorder)
* Individuals with symptomatic acute brain injury within 90 days of serious injury
* Individuals diagnosed with moderate to severe sleep apnea
* Individuals who are unable to identify a person or service to assure their safe transport to home post treatment