CompletedPhase 4ketamine

Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department

NCT ID

NCT04266288

Target Enrollment

29 participants

Start Date

2019-10-18

Est. Completion

2020-05-31

About This Study

The purpose of this study is to examine the effect of a low-dose ketamine infusion on depression symptoms within the Emergency Department (ED) visit, and healthcare utilization after leaving the ED, when administered in the ED for depression or suicidal ideation.

Conditions Studied

DepressionDepression SevereDepression AcuteDepression and SuicideSuicidal Ideation

Interventions

•Ketamine
•Sodium Chloride 0.9%

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Adults 18 years of age and older
* Presenting to the ED with a chief complaint of severe depression or suicidality, or presenting to the ED with any other chief complaint but answering "yes" to "Thoughts of harming/killing yourself?" during intake/triage

Exclusion Criteria:

* Acute mania or psychosis
* Enrollment in trial during a prior emergency department visit
* History of ketamine abuse or dependence
* Known hypersensitivity to ketamine
* Acute intoxication with any drug of abuse (including alcohol)
* Pregnancy or lactation
* Any condition that would place the patient at serious risk of harm from an increase in blood pressure (e.g. history of intracerebral hemorrhage, aneurysmal vascular disease, or arteriovenous malformation)
* Assessing provider does not want to enroll patient for any other reason, based on their clinical judgement

Study Locations (1)

MercyOne Des Moines Medical Center