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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 577624 of 1695 trials
Completed·N/A·ketamine

Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain

Defense and Veterans Center for Integrative Pain Management

Pain, AcuteAnalgesiaAmputation, Traumatic+2 more
Completed·N/A·ketamine

Effects of Propofol and Ketofol on Core Body Temperature in MRI

Istanbul University

Children
Completed·Phase 4·ketamine

A Comparison of Intra-op Ketamine vs Placebo in Patients Having Spinal Fusion

NYU Langone Health

Postoperative Pain
Completed·Phase 2·ketamine

A Study to Assess the Analgesic Properties of a Sublingual Wafer Formulation of Ketamine Following Third Molar Extraction

Lotus Clinical Research, LLC

Pain
Completed·Phase 3·ketamine

Ketofol Versus Fentofol for Procedural Sedation in the Pediatric Emergency Department

University of British Columbia

Emergency Department Procedural SedationFracture Reduction
Completed·Phase 1·psilocybin

UW Psilocybin Pharmacokinetics Study

University of Wisconsin, Madison

Healthy
Completed·Phase 1·ketamine

Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine

Janssen Research & Development, LLC

Allergic Rhinitis
Completed·Phase 2·psilocybin

A Double-Blind Trial of Psilocybin-Assisted Treatment of Alcohol Dependence

NYU Langone Health

Alcohol Dependence
Completed·Phase 1·ketamine

Biomarkers of Fast Acting Therapies in Major Depression

University of California, Los Angeles

Major Depressive Disorder
Completed·N/A·ketamine

Pre-Emptive Analgesia in Ano-Rectal Surgery

University of Vermont

HemorrhoidsFissure in AnoRectal Fistula+1 more
Completed·Phase 1·ketamine

A Study to Evaluate the Effect of Intranasal Esketamine on Cognitive Functioning in Healthy Subjects

Janssen Research & Development, LLC

Healthy
Completed·Phase 2·ketamine

A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide

Janssen Research & Development, LLC

Major Depressive Disorder
Completed·Phase 4·ketamine

Biomarker Assessment of Glutamatergic Target Engagement

New York State Psychiatric Institute

Healthy Controls
Completed·Phase 4·ketamine

The Effect of Intraoperative Ketamine on Opioid Consumption and Pain After Spine Surgery in Opioid-dependent Patients

Rigshospitalet, Denmark

Postoperative PainChronic PainAnalgesics
Completed·Phase 1·psilocybin

Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Johns Hopkins University

Healthy
Completed·Phase 2·MDMA

Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults

Lykos Therapeutics

Social Anxiety in Autistic Adults
Completed·Phase 4·ketamine

Dyphenhidramine Effect on Prevention of Sevoflurane Induced Post Anesthesia Agitation in Pediatric

Universitas Diponegoro

Specified SedativeHypnotic
Completed·N/A·ketamine

Plasma Concentration of Ketamine and Norketamine .

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Chronic Pain
Completed·Phase 2·ketamine

Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

Mayo Clinic

Critical Illness
Completed·Phase 1·Other

Effects of Hallucinogens and Other Drugs on Mood and Performance

Johns Hopkins University

Healthy
Completed·N/A·ketamine

Effects of Ketamine on Eye Movements, Perception and Brain Function

University of Bonn

Functional Neuroimaging
Completed·Phase 1·ketamine

Pre-hospital Care With Intra-Nasal Ketamine for Transport (PRECINKT): A Pilot Study

University of Calgary

PainTraumatic Limb Injury
Completed·Phase 1·LSD

A Phase 1 Study To Evaluate the Safety of Migalastat Hydrochloride Given Intravenously to Healthy Volunteers

Amicus Therapeutics

Fabry Disease
Completed·Phase 1·ketamine

A Pharmacokinetic, Safety and Tolerability Study of Esketamine in Healthy Elderly and Adult Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 2·LSD

Randomized, Controlled, Open-label, Multicenter, Safety and Efficacy Study of rhHNS Administration Via an IDDD in Pediatric Patients With Early Stage MPS IIIA Disease

Shire

Sanfilippo Syndrome
Completed·Phase 3·ketamine

The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial

Washington University School of Medicine

Delirium
Completed·Phase 2·ketamine

A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression

Janssen Research & Development, LLC

Treatment Resistant Depressive Disorder
Completed·Phase 3·Other

MAC vs TIVA Ambulatory Breast Augmentation

Ain Shams University

Breast Diseases
Completed·N/A·ketamine

The Effects of Ketamine on Respiratory Stimulation and Transpulmonary Pressures

Massachusetts General Hospital

Mechanical VentilationAirway PatencyRespiratory Depression
Completed·N/A·Other

Impact of Opioid Free Anesthesia on Outcome After DIEPflap Surgery

AZ Sint-Jan AV

Major and Minor Surgical Complications
Completed·N/A·MDMA

Exploring Mechanisms of Action in MDMA-assisted Psychotherapy for PTSD

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Phase 2·ketamine

Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients

NYU Langone Health

Depression
Completed·Phase 2·ketamine

Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)

New York State Psychiatric Institute

Obsessive-Compulsive Disorder
Completed·N/A·Other

Study of Tysabri in Early Relapsing Remitting Multiple Sclerosis Participants

Biogen

Relapsing Remitting Multiple Sclerosis
Completed·Phase 4·ketamine

Ketamine Effect After Laparoscopic Gastric Reduction: A Randomized, Double-Blinded, Placebo Controlled Study

Northwestern University

PainObesityHypoxia
Completed·Phase 2·ketamine

Novel Topical Therapies for the Treatment of Genital Pain

University of Rochester

Female Genital Diseases
Completed·Phase 1·ketamine

A Study to Assess the Pharmacokinetics of Intranasally Administered Esketamine in Healthy Japanese and Caucasian Volunteers

Janssen Research & Development, LLC

Healthy Volunteers
Completed·N/A·ketamine

CYP2B6 Polymorphisms in Ketamine

Washington University School of Medicine

Healthy Volunteers
Completed·N/A·Other

Biogen Multiple Sclerosis Pregnancy Exposure Registry

Biogen

Multiple SclerosisExposure During Pregnancy
Completed·N/A·psilocybin

Beyond the Self and Back: Neuropharmacological Mechanisms Underlying the Dissolution of the Self

University of Zurich

Healthy
Completed·Phase 1·ketamine

A Study to Evaluate the Pharmacokinetics of Intranasal Esketamine Administered With and Without a Nasal Guide on the Intranasal Device

Janssen Research & Development, LLC

Healthy
Completed·Early Phase 1·MDMA

Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI Study

University Hospital, Basel, Switzerland

HealthySubstance-related DisorderMood Disorder
Completed·N/A·ketamine

Inhaled Nitrous Oxide for the Prevention of Emergence Reaction During Ketamine Administration in Adults, a Pilot Study

Albert Einstein Healthcare Network

Emergence ReactionProcedural Sedation
Completed·N/A·ketamine

Pharmacokinetic Alterations During ECMO

Columbia University

Acute Respiratory Failure
Completed·N/A·ketamine

Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor

The University of Texas Health Science Center at San Antonio

Acute CholecystitisChronic Cholecystitis
Completed·N/A·ketamine

Anesthetics in Rhytidoplasty - A Comparison Study

Mercy Facial Plastic Surgery Center

Rhytidoplasty
Completed·Phase 1·ketamine

Ketamine for Suicidality in Bipolar Depression

New York State Psychiatric Institute

Bipolar DisorderMajor Depressive EpisodeSuicidal Ideation
Completed·Phase 4·ketamine

Ketamine Versus Etomidate for Rapid Sequence Intubation

Hennepin Healthcare Research Institute

Airway ControlAnesthesiaIntubation+1 more
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.