Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor

About This Study

The purpose of this study is to compare a closed-loop intravenous anesthetic using Bispectral Index as a feedback loop and a controller based on reinforcement learning to titrate dose and intravenous anesthetic that is manually controlled or a standard volatile anesthetic agent titrated by the anesthesiologist to determine improvement in the following parameters as compared to controls: time to discharge from the Post Anesthesia Care Unit, post-operative nausea and vomiting, pain scores and sedation scores.

Conditions Studied

Interventions

• •TIVA - Hypotension
• •TIVA - Hypertension
• •TIVA - Bradycardia
• •TIVA - Tachycardia
• •INH - Hypotension
• •INH - Hypertension
• •INH - Bradycardia
• •INH - Tachycardia

Eligibility

Inclusion Criteria:

* 18-65 years of age
* Body mass index lower or equal to 40 m2/kg
* Subjects must be able to comprehend spoken and written English or Spanish

Exclusion Criteria:

* Any type of psychiatric, neurological, or neuromuscular disorder
* Thyroid disease
* Alcohol consumption which exceeds 2 drinks per day and/or drug abuse.
* Allergy to study medication proposal, soy or egg proteins
* history of drug abuse
* chronic or acute use of opioids, or other medications affecting the central nervous system
* pregnancy

Study Locations (1)