CompletedN/Aketamine

Effects of Ketamine on Eye Movements, Perception and Brain Function

NCT ID

NCT02701933

Target Enrollment

24 participants

Start Date

2014-04

Est. Completion

2014-12

About This Study

In this study, the investigators examine the effects of low-dose ketamine on different oculomotor, perceptual and cognitive functions. They also examine effects on concurrent brain activity using blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). A sample of N=25 healthy, male participants is required to complete the study. The design is within-subjects, placebo-controlled, double-blind and cross-over. A targeted ketamine level in plasma of 100ng/ml is applied. It is hypothesised that ketamine, compared to placebo, will lead to changes in task performance and brain activity similar to those observed in patients with schizophrenia.

Conditions Studied

Functional Neuroimaging

Interventions

•Ketamine
•Saline

Eligibility

Sex:MALE

Age:18 Years - 45 Years

Healthy Volunteers:Yes

View full eligibility criteria

Inclusion Criteria:

* MRI-suitability
* suitability for video-based combined pupil and corneal reflection (VCPCR) eye-tracking
* good command of German language
* willingness to take part

Exclusion Criteria:

* any current or history of axis I disorder diagnosis as assessed by the Mini-International Neuropsychiatric Interview (M.I.N.I.)
* any neurological conditions and heart conditions
* use of any prescription or non-prescription medication up to one week before participation
* personal history of head-injuries, loss of consciousness, eye surgery or impairment of vision (other than corrective lenses)
* any other relevant medical conditions such as high blood pressure
* positive urine drug test (Drug-Screen Multi "5T", nal von minden GmbH)
* history of drug use or current drug use
* under- or overweight (below 18.5 and above 24.9 body mass index (BMI) values)
* any diagnosis of psychotic disorders among first-degree relatives

Study Locations (1)

University of Bonn

Bonn, North Rhine-Westphalia, Germany