CompletedPhase 2ketamine

Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)

NCT ID

NCT02062658

Target Enrollment

10 participants

Start Date

2013-12

Est. Completion

2015-12

About This Study

This study investigates if a single dose of IV Ketamine can rapidly improve Obsessive-Compulsive Disorder (OCD) symptoms and whether these effect can be maintained with a condensed course of a type of Cognitive Behavioral Therapy called Exposure and Response Prevention (EX/RP). You will be compensated for your time and travel. Participants must be between the ages of 18-55.

Conditions Studied

Obsessive-Compulsive Disorder

Interventions

•Ketamine
•Exposure and Response Prevention

Eligibility

Age:18 Years - 55 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Age 18-55
* Physically healthy and not currently pregnant
* Primary Diagnosis of OCD
* Sufficient severity of symptoms
* Currently off all psychotropic medication OR
* Currently on adequate dose of medication for treatment of OCD, but have not achieved at least partial remission
* Able to provide consent

Exclusion Criteria:

* Psychiatric conditions that make participation unsafe (schizophrenia \[either self or first degree relative e.g. siblings, parents\], history of violence, severe depression, eating disorder, substance dependence \[including nicotine\])
* Female patients who are either pregnant or nursing
* Planning to commence EX/RP during the period of the study or those who have completed an adequate dose of EX/RP (defined as 8 or more sessions within 2 months) within 8 weeks prior to enrollment.

period of the study

* Allergy to ketamine
* Participants for whom being off of medication is not clinically recommended
* Medical conditions that make participation unsafe (e.g. high blood pressure, head injury)
* Currently on medications that make participation unsafe

Study Locations (1)

New York State Psychiatric Insitute