CompletedN/AOther

Impact of Opioid Free Anesthesia on Outcome After DIEPflap Surgery

NCT ID

NCT03202134

Target Enrollment

204 participants

Start Date

2014-01

Est. Completion

2019-11-15

About This Study

The Deep Inferior Epigastric Perforator free flap (DIEPflap) involves the transfer of abdominal tissue to the breast using microsurgery. Flap failure is rare today, but is devastating. Blood flow in a DIEPflap decreases during the first hours. Many anesthetic factors like low cardiac output, hypothermia and surgical stress cause vasoconstriction or thrombosis. A stable anesthesia during these long procedures improves flap perfusion. Postoperative nausea and vomiting (PONV) is frequent and might have an impact. Opioid free anesthesia (OFA) reduces PONV. The anti-inflammatory and vasodilator effects of the drugs dexmedetomidine and lidocaine might improve free flap perfusion. The primary outcome counted all complications. The secondary outcomes were PONV, pain, opioid consumption, skin flap temperature and length of hospital stay. Patients get according to attending anesthesiologist an opioid or opioid free anesthesia without any randomization but based on availability of competence.

Conditions Studied

Major and Minor Surgical Complications

Interventions

•opioid free anesthesia

Eligibility

Sex:FEMALE

Age:18 Years - 75 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria: DIEPflap unilat or bilat woman between 18 and 60 years old-

Exclusion Criteria: none

* allergy to any of the drugs used in anesthesia

Study Locations (1)

Azsintjan

Bruges, Belgium