CompletedPhase 2ketamine

Ketamine / Propofol Admixture "Ketofol" at Induction in the Critically Ill Against Etomidate: KEEP PACE Trial

NCT ID

NCT02105415

Target Enrollment

160 participants

Start Date

2014-04

Est. Completion

2018-08-01

About This Study

The hypothesis of this study is that a Ketamine / Propofol mixture will produce more stable hemodynamics as compared to Etomidate during emergent intubations in the intensive care unit. Patients that require a breathing tube to be placed in the ICU will be randomized to receIve either a Ketamine / Propofol mixture or Etomidate for sedation in order to place the breathing tube.

Conditions Studied

Critical Illness

Interventions

•Ketamine / Propofol Admixture
•Etomidate

Eligibility

Age:18 Years - 99 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* 18 years of age or older
* Surgical or medical intensive care unity patients requiring endotracheal intubation
* Consulting physician agrees to study plan and will follow drug randomization

Exclusion Criteria:

* Known intracranial pathology
* Known chronic opiate-dependence
* Received continuous sedative infusion in the last 24 hours
* Known severe psychiatric illness
* Known egg allergies
* Known contraindication to fentanyl, midazolam, ketamine, propofol or etomidate
* Intubation in which standard practice is not to use sedation
* No known documented weight or weight greater than 140 kg or less than 30 kg
* Prior participation in the study
* Of childbearing age (18-50) with no known negative pregnancy test on this admission.

Study Locations (1)

Mayo Clinic

Rochester, Minnesota, United States