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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 337384 of 1695 trials
Completed·Early Phase 1·psilocybin

Direct Comparison of Altered States of Consciousness Induced by LSD and Psilocybin

University Hospital, Basel, Switzerland

Healthy
Completed·Early Phase 1·ketamine

Ketamine for Refractory Chronic Migraine: a Pilot Study

Thomas Jefferson University

Migraine Headache With Intractable Migraine
Completed·Phase 1·DMT

Safety of GH001 in Healthy Volunteers

GH Research Ireland Limited

Healthy Volunteers
Completed·Phase 2·ketamine

A Study to Evaluate Ketamine for the Treatment of Rett Syndrome

Rett Syndrome Research Trust

Rett Syndrome
Completed·Phase 2·psilocybin

Clinical, Neurocognitive, and Emotional Effects of Psilocybin in Depressed Patients - Proof of Concept

University of Zurich

Depressive Disorder, Major
Completed·Phase 2·psilocybin

The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression

COMPASS Pathways

Treatment Resistant Depression
Completed·N/A·Other

Impact of Opioid Free Anesthesia on Outcome After Hip Arthroplasty by Direct Anterior Approach.

AZ Sint-Jan AV

Hip Arthropathy
Completed·Phase 2·ketamine

Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression

Celon Pharma SA

Major Depressive Disorder
Completed·Phase 1·ketamine

A Study to Evaluate Central Nervous System (CNS) Pharmacodynamic Activity of TAK-653 in Healthy Participants Using Transcranial Magnetic Stimulation (TMS)

Neurocrine Biosciences

Healthy Volunteers
Completed·Phase 2·ketamine

Proof of Concept Study Evaluating the Efficacy and Safety of MIJ821 in Patients With Treatment-resistant Depression

Novartis Pharmaceuticals

Depressive Disorder, Treatment-Resistant
Completed·N/A·ketamine

The Anti-inflammatory Effect of Anesthetics in Abdominal Surgery

University Hospital Dubrava

Colorectal Cancer
Completed·Phase 3·ketamine

Lamotrigine in Reducing Psychologic Side-Effect of Perioperative Ketamine

The Cleveland Clinic

Reducing Psychological Side Effects of Ketamine
Completed·Phase 4·Other

Multimodal Versus Opioid aNalgesia in carDiAc Surgery

University Hospital, Ghent

Postoperative PainPostoperative Delirium
Completed·Phase 2·psilocybin

Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms

Imperial College London

Depressive Disorder, Major
Completed·Phase 1·psilocybin

Psilocybin for Treatment of Obsessive Compulsive Disorder

University of Arizona

Obsessive-compulsive Disorder (OCD)
Completed·N/A·Other

Opioid Free Anaesthesia in Cardiac Surgery With Cardiopulmonary Bypass

Centre Hospitalier Universitaire Dijon

Opioid Free AnaesthesiaOpioid Anaesthesia
Completed·Phase 1·ketamine

A Study to Assess Electrophysiology, Safety, Tolerability, and Pharmacokinetics of Multiple Doses of SAGE-718 Using Ketamine Challenge in Healthy Subjects

Supernus Pharmaceuticals, Inc.

Healthy Volunteer
Completed·Phase 1·ketamine

A Study to Investigate the Different Modes of (S) Ketamine Administration in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 1·ketamine

Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial

Yale University

Depressive Disorder, MajorPost Traumatic Stress DisorderBipolar Disorder
Completed·N/A·Other

Personality Disorders and Substance Use Disorders in a Sexual Context in the Man Having Sex With Other Men Population

Hospices Civils de Lyon

Substance Use Disorders
Completed·Phase 3·MDMA

A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Phase 1·psilocybin

Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.

Yale University

Obsessive-Compulsive Disorder
Completed·Phase 1·ketamine

A Study to Assess the Electrophysiology, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Response Using Magnetic Resonance Imaging of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

Supernus Pharmaceuticals, Inc.

Healthy Volunteer
Completed·Phase 1·ketamine

Assessment of Effect of Rapastinel on Driving Performance

Naurex, Inc, an affiliate of Allergan plc

Driving Performance
Completed·N/A·Other

Acupuncture ACL (Anterior Cruciate Ligament)

Hospital for Special Surgery, New York

ACLACL InjuryAnterior Cruciate Ligament Injury+2 more
Completed·Phase 1·ketamine

Assessment of Abuse Potential of Rapastinel in Humans

Naurex, Inc, an affiliate of Allergan plc

Human Abuse Potential
Completed·Phase 2·ketamine

EEG Studies of Ketamine General Anesthesia

Massachusetts General Hospital

Anesthesia
Completed·Phase 4·ketamine

Sub-dissociative Dose Ketamine Dosing Study

Loyola University

Acute Pain
Completed·Phase 4·ketamine

Impact of the Use of Ketamine in Laparoscopic Surgery.

Universidade do Porto

Quality of Recovery
Completed·Phase 4·ketamine

Comparison of BIS Index Variations: Bolus Versus Infusion Ketamine, and Impact on the Anesthesia Gas Consumption

Ciusss de L'Est de l'Île de Montréal

Bolus Versus Infusion Ketamine, Anesthesia Gas Consumption
Completed·Phase 1·ketamine

A Study to Assess the Electrophysiology, Safety, Tolerability, and Pharmacokinetics of SAGE-718 Using a Ketamine Challenge in Healthy Subjects

Supernus Pharmaceuticals, Inc.

Healthy Volunteer
Completed·N/A·ketamine

Assessment of Ketamine and Propofol Sedation During LISA Method (Less Invasive Surfactant Administration)

University Hospital, Montpellier

Premature Neonate
Completed·N/A·ketamine

Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine

Psych Atlanta

Treatment Resistant Depression
Completed·Phase 1·ketamine

Ketamine for Treatment of MS Fatigue

Johns Hopkins University

Multiple SclerosisFatigue
Completed·N/A·Other

Impact of OFA During LPV on Postoperative Oxygen Saturation

AZ Sint-Jan AV

Decreased Lung ComplianceOxygen Requirement
Completed·Phase 2·ketamine

Opioid Versus Non-opioid Anesthesia for Ambulatory Surgery in Children

Athens General Children's Hospital "Pan. & Aglaia Kyriakou"

Effect of Anesthesia in Postoperative PainEffect of Anesthesia in Extubation TimeEffect of Anesthesia in Discharge Time From Postanesthesia Care Unit+2 more
Completed·Phase 2·ketamine

Study of Ketamine for Depression in Cancer Patients Receiving Palliative Care

University Health Network, Toronto

DepressionCancerPalliative Care
Completed·Phase 4·ketamine

Narcotic Free TIVA and Incidence of Unacceptable Movements Under Anesthesia During ACDF Surgery

University of Arkansas

Anterior Cervical Discectomy and Fusion (ACDF)
Completed·Phase 3·ketamine

Intranasal Ketamine and Fracture Reduction in Pediatric Emergencies (KETAPED)

Fondation Lenval

Fractures, Closed
Completed·Phase 4·ketamine

Postpartum Perineal Pain After Obstetric Anal Sphincter Injuries

Northwestern University

PainPostpartum Depression
Completed·N/A·Other

PEF-Block & Ribs Fractures

University Hospital, Montpellier

Chest Trauma With Ribs Fractures
Completed·Phase 4·ketamine

Analgesics in the Pre-hospital Setting: Implications on Hemorrhage Tolerance - Ketamine

University of Texas Southwestern Medical Center

HemorrhageHealthy
Completed·Phase 3·Other

Evaluation of Anterior Quadratus Lumborum Block for Postoperative Analgesia in Hip Arthroscopy

Hospital for Special Surgery, New York

Hip Disease
Completed·Phase 2·ketamine

Does Subacromial Injection With Glutamate Receptor Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy?

Helse Møre og Romsdal HF

Rotator Cuff TendinitisChronic Pain
Completed·Phase 2·ketamine

Rapid Agitation Control With Ketamine in the Emergency Department

David Barbic

Violent Aggressive BehaviorKetamine
Completed·Phase 3·ketamine

A Study to Evaluate the Efficacy, Pharmacokinetics, Safety and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 3·ketamine

Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse

The University of Texas Health Science Center, Houston

Suicidal IdeationDepressionAlcohol Abuse
Completed·Phase 1·Other

Mood Effects of Serotonin Agonists

University of Chicago

Healthy
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.