CompletedPhase 4ketamine

Sub-dissociative Dose Ketamine Dosing Study

NCT ID

NCT03714620

Target Enrollment

98 participants

Start Date

2018-10-15

Est. Completion

2019-09-17

About This Study

Goal is to determine if in adults presenting to the Emergency Department (ED) with moderate to severe acute pain, Ketamine administered at 0.15 mg/kg will provide similar pain relief to Ketamine administered at 0.3 mg/kg, with fewer adverse effects.

Conditions Studied

Acute Pain

Interventions

•Ketamine

Eligibility

Age:18 Years - 59 Years

Healthy Volunteers:Yes

View full eligibility criteria

Inclusion Criteria:

* Adults ages 18-59
* Weight 45 - 115 kg
* Acute abdominal, flank, back, musculoskeletal pain, or a headache
* Onset of pain within 7 days
* Pain score of 5 or more
* Requiring intravenous analgesia
* Hasn't been enrolled in this study previously

Exclusion Criteria:

* Pregnancy
* Breast-feeding
* Altered mental status rendering the patient unable to consent to the study
* Allergy to ketamine
* Unstable vital signs (systolic blood pressure \<90 or \>180 mm Hg, pulse rate \<50 or \>150 beats/minute, and respiration rate \<10 or \>30 breaths/minute)
* History of acute head or eye injury, seizure, intracranial hypertension
* Chronic pain
* Renal or hepatic insufficiency
* Known alcohol or drug use disorder
* Currently under influence of alcohol/opiates
* Acute psychiatric illness

Study Locations (1)

Loyola University Medical Center

Maywood, Illinois, United States