181 Recruiting Now

Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 148 of 1013 trials
Active, Not Recruiting·Early Phase 1·ketamine

Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

CAMC Health System

SedationInterventional RadiologyBiopsy+1 more
Active, Not Recruiting·Phase 4·ketamine

Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression

Stanford University

Chronic PainDepression
Active, Not Recruiting·N/A·ketamine

Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and Anhedonia

University Hospital, Montpellier

Depression - Major Depressive DisorderDepression DisorderSuicide
Active, Not Recruiting·Phase 2·ketamine

Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment

Icahn School of Medicine at Mount Sinai

DepressionMild Cognitive Impairment
Active, Not Recruiting·Phase 2·ketamine

Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial

New York State Psychiatric Institute

Post-acute Sequelae of COVID-19Depressive SymptomsCognitive Dysfunction
Active, Not Recruiting·Phase 2·ketamine

Ketamine for Multiple Sclerosis Fatigue

Johns Hopkins University

Multiple Sclerosis Fatigue
Active, Not Recruiting·Phase 4·ketamine

Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study

Ohio State University

Major Depressive Disorder
Active, Not Recruiting·Phase 4·ketamine

Ketamine and Kidney Injury in Cardiac Surgery

Mayo Clinic

Cardiac Surgery
Active, Not Recruiting·Phase 3·ketamine

Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain

NYU Langone Health

Chronic Postsurgical Pain
Active, Not Recruiting·Phase 4·ketamine

Ketamine vs Lidocaine in Traumatic Rib Fractures

Brittany Hoyte

Rib FracturesRib Fracture MultipleRib Trauma
Active, Not Recruiting·Phase 4·ketamine

Ketamine + Cognitive Training for Suicidality in the Medical Setting

Rebecca Price

Suicide, Attempted
Active, Not Recruiting·N/A·ketamine

Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia

Wilderman Medical Clinic

Fibromyalgia
Active, Not Recruiting·Phase 3·ketamine

Opiate Suicide Study in Patients With Major Depression

Stanford University

Major Depressive Disorder
Active, Not Recruiting·Phase 3·ketamine

Perioperative Lidocaine and Ketamine in Abdominal Surgery

The Cleveland Clinic

Postoperative Pain
Active, Not Recruiting·Early Phase 1·ketamine

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:

Mayo Clinic

Major Depressive DisorderTreatment Resistant DepressionBipolar Depression
Active, Not Recruiting·Phase 3·ketamine

Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain

Jason McMullan

Acute Traumatic Pain
Active, Not Recruiting·Phase 2·ketamine

Understanding How Ketamine Brings About Rapid Improvement in OCD

Stanford University

Obsessive-Compulsive Disorder
Approved for Marketing·N/A·ketamine

Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

Mayo Clinic

Allergy
Completed·Phase 1·ketamine

Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)

The University of Texas Health Science Center at San Antonio

Post Traumatic Stress Disorder PTSD
Completed·Phase 1·ketamine

Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·ketamine

KF2024#1-trial: Esketamine Interaction Study

Helsinki University Central Hospital

Drug InteractionsFood-drug Interaction
Completed·Phase 2·ketamine

FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression

Brian Barnett

Bipolar DepressionTreatment Resistant Bipolar Depression
Completed·N/A·ketamine

Effect of Ketamine, Amitriptyline and Their Combination on Itch

Aalborg University

Itch
Completed·N/A·ketamine

Use of Ketamine in Severe Pain Syndromes

Erasme University Hospital

Pain, IntractablePain, ChronicPain Syndrome+1 more
Completed·N/A·ketamine

(GluEsk) Glutamate and Esketamine

University of Oxford

Depression
Completed·N/A·ketamine

Opioid-based Versus Opioid-free Endotracheal Intubation

Aretaieion University Hospital

AnesthesiaAnesthesia IntubationOpioid Use+2 more
Completed·N/A·ketamine

Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Depressive Disorder
Completed·Phase 2·ketamine

A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder

Clexio Biosciences Ltd.

Adjunctive Treatment of Major Depressive Disorder (MDD)
Completed·Early Phase 1·ketamine

Ketamine for MS Fatigue

Alta Bates Summit Medical Center

Multiple Sclerosis
Completed·N/A·ketamine

Sustained Ketamine Effectiveness for Suicidal Ideation

University Hospital, Montpellier

Depression - Major Depressive DisorderSuicide
Completed·N/A·ketamine

Standardised Drug Provocation Testing in Perioperative Hypersensitivity

University Hospital, Antwerp

Allergic ReactionHypersensitivityPerioperative Complication+4 more
Completed·Phase 4·ketamine

Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial

Unity Health Toronto

Neuropathic Pain
Completed·N/A·ketamine

Tapping in Together: A Pilot Study on Group Acupuncture for Ketamine Experience Integration

Academy of Oriental Medicine Austin

Acupuncture
Completed·Phase 1·ketamine

KET-RO Plus RO DBT for Treatment Resistant Depression

Washington University School of Medicine

Treatment Resistant Depression
Completed·N/A·ketamine

Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery

Hospital dos Lusíadas

Morbid ObesityPostoperative PainOpioid Free Anesthesia+1 more
Completed·Phase 1·ketamine

Ketamine Tolerated Dose for Postpartum Depression and Pain After Cesarean Delivery (PREPARE 1)

Grace Lim, MD, MS

Pain, PostoperativeDepression, Postpartum
Completed·N/A·ketamine

Brain Network Dynamics of Depression During Esketamine Treatment

University of North Carolina, Chapel Hill

Depressive Disorder, Major
Completed·N/A·ketamine

The Postoperative Lidocaine and Ketamine Effects on Morphine Requirement in Bariatric Surgery

Tiva Group

Pharmacological ActionPost Operative PainOpioid Use+2 more
Completed·N/A·ketamine

Lidocaine and Ketamine Levels in Plasma After Simultaneous Lidocaine/Ketamine Infusions

University Hospital, Basel, Switzerland

Chronic Pain
Completed·Early Phase 1·ketamine

Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder

Medical University of South Carolina

Tobacco UseSmoking CessationNicotine Dependence
Completed·N/A·ketamine

Observation of Safety and Tolerability Within 1 Year of the Use of R-ketamine / Placebo in Drug-resistant Depression

Medical University of Gdansk

Treatment-Resistant DepressionMajor Depressive Disorder
Completed·N/A·ketamine

Effect of Ketamine Infusion on BIS Values

University of Padova

Anesthesia Brain MonitoringKetamine
Completed·N/A·ketamine

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

Beth Israel Deaconess Medical Center

Postoperative DeliriumHemodynamic InstabilityPain+1 more
Completed·Early Phase 1·ketamine

The Effects of Sedatives on Tobacco Use Disorder Version 2

Wake Forest University Health Sciences

Tobacco Smoking
Completed·Phase 4·ketamine

Low Dose Ketamine Infusion for Analgesia in the Emergency Department to Reduce Side Effects

Summa Health System

Pain, AcuteDissociation
Completed·Phase 4·ketamine

Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

Maimonides Medical Center

Treatment Resistant DepressionMajor Depressive DisorderAnalgesia+10 more
Completed·Phase 3·ketamine

Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents

University of Texas Southwestern Medical Center

Suicide, AttemptedSuicide and DepressionSuicide Threat
Page 1 of 22Next

Browse by Condition

View all conditions →

How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.