Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression

About This Study

The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression. We do not know whether ketamine will be more effective than placebo under these circumstances. This study aims to: * Evaluate whether placebo is non-inferior to ketamine in treating chronic pain and depression, when delivered under propofol sedation * Confirm that propofol sedation is a safe way to keep participants blinded to treatment * Assess patients' comfort with the sedation process to improve future studies * Explore whether patient expectations affects their pain and depression Participants will: * Need to qualify for the study based on stringent medical criteria * Undergo sedation with propofol * Randomly receive either a ketamine or a placebo (saline) infusion during sedation * Complete several study assessments over 5-7 weeks

Conditions Studied

Interventions

• •Ketamine
• •Normal saline

Eligibility

Inclusion Criteria:

* Age 18 to 70 years old
* Comfortable speaking and writing in English
* Chronic pain present daily for at least 3 months
* Currently experiencing depression
* Able to comply with the study protocol and communicate with study personnel about adverse events and other clinically important information

Exclusion Criteria:

* Pregnant or breastfeeding
* One or more health conditions that makes study unsafe or unfeasible, determined by study physicians
* Regular use of medications that may have problematic interactions with the study drugs
* Participating in another clinical trial which may conflict with this one

Study Locations (1)