CompletedN/Aketamine

Opioid-based Versus Opioid-free Endotracheal Intubation

NCT ID

NCT06464393

Target Enrollment

70 participants

Start Date

2024-03-20

Est. Completion

2025-03-20

About This Study

The aim of this study will be to investigate the effect of opioid-free induction versus opioid-based induction on hemodynamic response and nociception level index during elective operations

Conditions Studied

AnesthesiaAnesthesia IntubationOpioid UseAnalgesic Non-narcoticFentanyl

Interventions

•ketamine-lidocaine-dexmedetomidine
•fentanyl

Eligibility

Age:18 Years - 80 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* adult patients
* American Society of Anesthesiologists (ASA) classification I-II
* Mallampati classification 1, 2 or 3

Exclusion Criteria:

* anticipated difficult airway (Mallampati 4 classification, thyromental distance \< 6 cm, mouth opening \< 3 cm, neck extension\< 80
* atrioventricular block
* bradycardia (heart rate less than 55/min)
* preadministration of beta-blockers
* eligibility for rapid-sequence induction
* chronic use of opioid medications
* known allergy to induction agents
* history of psychiatric disease
* language or communication barriers or lack of informed consent

Study Locations (1)

Aretaieion University Hospital

Athens, Greece