CompletedN/Aketamine

Standardised Drug Provocation Testing in Perioperative Hypersensitivity

NCT ID

NCT06065137

Target Enrollment

50 participants

Start Date

2023-10-23

Est. Completion

2025-06-30

About This Study

The goal of this clinical trial is to evaluate the safety and outcome of systematic drug provocation testing with anaesthetics at therapeutic doses in adult patients undergoing diagnostic work-up for perioperative hypersensitivity.

Conditions Studied

Allergic ReactionHypersensitivityPerioperative ComplicationAnaphylaxisAnaphylactic ReactionImmediate HypersensitivityHypersensitivity, Drug

Interventions

•Full dose DPT with propofol
•Full dose DPT with ketamine
•Full dose DPT with etomidate
•Full dose DPT with midazolam
•Full dose DPT with fentanyl
•Full dose DPT with sufentanyl
•Full dose DPT with alfentanil
•Full dose DPT with remifentanil
•Full dose DPT with rocuronium
•Full dose DPT with atracurium
•Full dose DPT with cisatracurium
•Full dose DPT with succinylcholine

Eligibility

Age:18 Years - N/A

Healthy Volunteers:Yes

View full eligibility criteria

Inclusion Criteria:

* patients consulting the allergology department of the Antwerp University hospital medical with a history consistent with perioperative hypersensitivity
* Indication for diagnostic work-up as determined at an interdisciplinary meeting between allergologists and anaesthetists
* willing to sign separate informed consent forms for both general anaesthesia and the Drug Provocation Test.

Exclusion Criteria:

* patient refusal
* incomplete diagnostic work-up
* history inconsistent with perioperative hypersensitivity

Study Locations (1)

Antwerp University Hospital

Edegem, Antwerp, Belgium