Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

About This Study

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

Conditions Studied

Interventions

• •ketamine
• •fentanyl
• •Midazolam

Eligibility

Inclusion Criteria:

* Planned to undergo image-guided bone biopsy, lung biopsy, or percutaneous drainage
* Eligible to receive ketamine or fentanyl sedation
* Any sex/gender, any race
* Aged 18-89

Exclusion Criteria:

* Pregnant/lactating
* Incarceration
* Currently taking an opioid agonist/antagonist
* Food consumed in past 6-8 hours
* Allergies to drugs used in the study
* Lacks mental capacity for reporting pain scores
* Hypotension or respiratory failure precluding fentanyl sedation
* Uncontrolled hypertension precluding ketamine sedation
* Condition for which hypertension would be a concern
* Schizophrenia

Study Locations (1)