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Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 865–912 of 1695 trials
Enrolling by Invitation·N/A·ketamine
Observational Study of Ketamine Infusions for the Treatment of Chronic Pain
Theresa Lii
Chronic Pain
Enrolling by Invitation·N/A·ketamine
Long-term Pain Modulation by Intravenous Esketamine in CRPS
Erasmus Medical Center
Complex Regional Pain SyndromesCRPS (Complex Regional Pain Syndromes)
Enrolling by Invitation·N/A·ketamine
Effect of Ketamine and Etomidate During RSI on Long Term Outcomes
Vanderbilt University Medical Center
Post-Traumatic Stress DisorderAcute Respiratory Failure
Enrolling by Invitation·Phase 3·Other
GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries
Hospital for Special Surgery, New York
Lumbar Disc HerniationLumbar Disc DiseaseLumbar Radiculopathy
Enrolling by Invitation·Phase 4·ketamine
Ketamine Infusion for Neuropathic Pain in Brachial Plexus Injuries
Mayo Clinic
Brachial Plexus Injury
No Longer Available·N/A·MDMA
A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTSD
Lykos Therapeutics
Post Traumatic Stress Disorder
Not Yet Recruiting·Phase 1·psilocybin
The Effects of Psilocybin in Healthy Volunteers: Psychological, Biochemical and Electrophysiological Biomarkers.
Gabriella Gobbi
Healthy ParticipantsPlacebo - ControlPsilocybin
Not Yet Recruiting·Phase 2·ketamine
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
Oman Medical Speciality Board
Asthma AcuteAsthma AttackAsthma Exacerbations
Not Yet Recruiting·N/A·Other
Awareness Neuraxial Versus General Anesthesia in Frail Patients Undergoing Laparoscopic or Robotic Abdominopelvic Surgery.
Ente Ospedaliero Ospedali Galliera
FrailyAbdominal SurgeryPostoperative Cognitive Dysfunction (POCD)
Not Yet Recruiting·Phase 1·psilocybin
Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder
Indiana University
Treatment Resistant DepressionSubstance Use Disorders
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence
University of Calgary
Post Traumatic Stress Disorder PTSDIntimate Partner Violence (IPV)
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)
NYU Langone Health
IBS - Irritable Bowel Syndrome
Not Yet Recruiting·Phase 1·LSD
Shortened LSD Intervention for Major Depressive Disorder
Johns Hopkins University
Major Depression ModerateMajor Depression SevereMajor Depression
Not Yet Recruiting·Phase 1·psilocybin
Psilocybin After Trauma Surgery for Pain
Trent Emerick
Pain ManagementPostoperative Pain
Not Yet Recruiting·Phase 2·ketamine
Ketamine HCl Prolonged Release Oral Tablets for CRPS
University of Southern California
Complex Regional Pain Syndromes
Not Yet Recruiting·Phase 2·psilocybin
Anesthesia-Masked Psilocybin Therapy for Major Depression
Stanford University
Major Depression
Not Yet Recruiting·Phase 2·ketamine
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
National Center for Complementary and Integrative Health (NCCIH)
PainHealthy Volunteers
Not Yet Recruiting·Phase 3·psilocybin
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
VA Office of Research and Development
Major Depression
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
Yale University
Chronic Low Back Pain (CLBP)Physical TherapyPsilocybin
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids
Roswell Park Cancer Institute
Hematopoietic and Lymphatic System NeoplasmMalignant Solid Neoplasm
Not Yet Recruiting·Phase 2·psilocybin
NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy
M.D. Anderson Cancer Center
PsilocybinNeuropathy
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Psychotherapy for the Treatment of Severe Alcohol Use Disorder
Brigham and Women's Hospital
Alcohol Use Disorder
Not Yet Recruiting·Phase 3·ketamine
Morphine or Ketamine for Analgesia
Columbia University
Abdominal PainIsolated Extremity FracturePain+1 more
Not Yet Recruiting·Phase 4·ketamine
Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts
New York State Psychiatric Institute
Major Depressive Disorder (MDD)
Not Yet Recruiting·Phase 1·psilocybin
Group Psilocybin-Assisted Therapy for Post-Traumatic Stress Disorder
University of New Mexico
PTSD
Not Yet Recruiting·Phase 2·psilocybin
Mindfulness-based Psilocybin Therapy for PTSD
Anthony P King
Post Traumatic Stress DisorderDepression - Major Depressive Disorder
Not Yet Recruiting·Phase 3·ketamine
InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression
Sunnybrook Health Sciences Centre
Treatment Resistant Depression
Not Yet Recruiting·Phase 4·ketamine
Esketamine Versus Crisis Response Planning Versus Optimized Treatment as Usual for Suicide Prevention: A Pragmatic Controlled Trial in Two Brazilian Cities
University of Sao Paulo
Suicide PreventionKetamineCrisis Response Plan
Not Yet Recruiting·Phase 4·Other
Examining Analgesic Synergy and Efficacy in Trauma Care
Wake Forest University Health Sciences
Opioid Use Disorder
Not Yet Recruiting·Phase 2·MDMA
MDMA-Assisted Therapy for Veterans With PTSD and Alcohol Use Disorder
VA Office of Research and Development
Post Traumatic Stress DisorderAlcohol Use Disorder
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin Microdosing on Cognition, Mood and Quality of Life
Yale University
Psychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin AsSisted pSychotherapy for the treatmENt of Gambling disordER : a Pilot Study
Nantes University Hospital
Gambling Disorder
Not Yet Recruiting·Phase 2·psilocybin
Evaluating the Role of Psilocybin Monitors in Psilocybin Therapy for Treatment Resistant Depression
Centre for Addiction and Mental Health
Treatment-Resistant Depression
Not Yet Recruiting·Phase 1·psilocybin
Consciousness and Psilocybin Effects on Well-Being: The CoPEWell Study
University of Wisconsin, Madison
Well-Being, PsychologicalPsychedelic Experiences
Not Yet Recruiting·Phase 2·psilocybin
Subjective Experience Following Psilocybin
University of Calgary
Investigating the Importance of the Subjective Psychedelic Experience
Not Yet Recruiting·Phase 2·MDMA
MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers
Nautilus Sanctuary
Post-Traumatic Stress DisorderAdjustment Disorders
Not Yet Recruiting·Phase 1·MDMA
MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function
Lykos Therapeutics
PharmacokineticsHepatic Impairment
Not Yet Recruiting·N/A·ketamine
Ultrasound Guided Pecs Block and Ketamine Infusion for Preventing Chronic Pain in Patients Undergoing Breast Cancer Surgery
Aga Khan University
Breast CancerPain, ChronicPost Surgical Pain
Not Yet Recruiting·Phase 1·ketamine
KF2025#1 Trial: Ketamine, Cannabidiol and Cobicistat Interaction Study
Helsinki University Central Hospital
Drug Drug Interaction
Not Yet Recruiting·Phase 4·ketamine
The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.
University of Missouri-Columbia
Spine Surgery
Not Yet Recruiting·Early Phase 1·Other
Transition From Acute to Chronic Opioid Use and Chronic Pain
Jacques E. Chelly
Opioid Use Disorder
Not Yet Recruiting·N/A·Other
Comparison Between Two Drugs in Sedation of Upper GI Endoscopy
Zagazig University
Sedation During GI Endoscopy
Not Yet Recruiting·Phase 3·Other
Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery
Centre Hospitalier Universitaire, Amiens
Intravenous LidocaineLaparoscopic SurgeryPost Operative Recovery+1 more
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Randomized Therapy
Emory University
PTSD
Not Yet Recruiting·Early Phase 1·ketamine
The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain.
National and Kapodistrian University of Athens
Opioid-Refractory Chronic Cancer-Related Pain
Not Yet Recruiting·Phase 1·psilocybin
A Study of Psychedelics in Healthy Older Adults With Low Well-being
Jennifer Mitchell
Anhedonia in Healthy VolunteersOlder Adults (50-90 Years)
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-assisted Therapy for Comorbid Major Depressive Disorder and Alcohol Use Disorder
Centre for Addiction and Mental Health
Major Depressive Disorder (MDD)Alcohol Use Disorder (AUD)
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD
Unity Health Toronto
Post Traumatic Stress DisorderPTSDChronic PTSD
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View all conditions →How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.