Not Yet RecruitingPhase 4Other

Examining Analgesic Synergy and Efficacy in Trauma Care

NCT ID

NCT07435077

Target Enrollment

282 participants

Start Date

2026-05

Est. Completion

2026-09

About This Study

Traumatic injury is responsible for over 25 million (16%) Emergency Department visits and over 225,000 deaths each year per 2021 Center for Disease Control data. This is the 3rd leading cause of death in the US. Often, acute care for the injured patient requires administration of pain medication for the purposes of acute pain control from injury. The mainstay of treatment for pain control has historically involved opioid pain medication.

Conditions Studied

Opioid Use Disorder

Interventions

•Buprenorphine
•Oxycodone

Eligibility

Age:18 Years - 80 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Adult patients with injury to at least 2 body locations as defined by Abbreviated Injury Scale (AIS) scores (Head, Face, Neck, Chest, Abdomen/Pelvis, Spine, Upper Extremity, Lower Extremity, External)

Exclusion Criteria:

* Glasgow Coma Scale (GCS) \<15 - Patients may be included if their GCS improves to 15 within 24 hours of admission
* Age \<18 years
* Age ≥80years
* Prisoners
* Pregnant patients
* Non-English speakers
* Inability to provide consent
* Home buprenorphine or methadone use
* Home opioid use \>45 Morphine Milligram Equivalents (MME)/day
* Allergy to any medication within the study or control arm
* Patients undergoing treatment for alcohol withdrawal
* History of cirrhosis requiring dose adjustment of Tylenol

Study Locations (1)

Wake Forest University Health Sciences

Winston-Salem, North Carolina, United States