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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 4996 of 267 trials
Completed·Phase 2·ketamine

Ketamine for the Treatment of Opioid Use Disorder and Depression

Medical University of South Carolina

DepressionOpioid-use DisorderOpioid Abuse
Completed·Phase 4·ketamine

Ketamine for Older Adults Pilot

Washington University School of Medicine

Treatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more
Completed·Phase 4·ketamine

Ketamine Treatment Effects on Synaptic Plasticity in Depression

New York State Psychiatric Institute

Major Depressive Disorder
Completed·N/A·ketamine

Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression

Mclean Hospital

Major Depressive Disorder
Completed·Phase 2·psilocybin

The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression

COMPASS Pathways

Treatment Resistant Depression
Completed·N/A·Other

Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)

COMPASS Pathways

Treatment Resistant Depression
Completed·Phase 4·ketamine

A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health

Field Trip Health

DepressionAnxietyPost Traumatic Stress Disorder
Completed·N/A·ketamine

A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders

Medical University of Gdansk

Treatment Resistant DepressionBipolar DepressionKetamine+1 more
Completed·N/A·ketamine

Chart Review of Patients Undergoing Ketamine Infusions

Brain and Cognition Discovery Foundation

Major Depressive DisorderBipolar DisorderObsessive-Compulsive Disorder+1 more
Completed·Phase 1·DMT

Clinical Study of GH001 in Depression

GH Research Ireland Limited

Treatment Resistant DepressionMajor Depressive DisorderDepression
Completed·Phase 2·LSD

LSD Therapy for Persons Suffering From Major Depression

University Hospital, Basel, Switzerland

Major Depressive Disorder
Completed·Phase 4·ketamine

Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department

MercyOne Des Moines Medical Center

DepressionDepression SevereDepression Acute+2 more
Completed·Phase 1·ketamine

Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans

University of Minnesota

Post-Traumatic Stress DisordersMajor Depressive Disorder
Completed·Phase 4·ketamine

Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery

Stanford University

Major Depressive DisorderSurgeryOrthopedic Disorder
Completed·Phase 2·ketamine

Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Bipolar Depression

Celon Pharma SA

Bipolar Depression
Completed·Phase 2·psilocybin

The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression

COMPASS Pathways

Treatment Resistant Depression
Completed·Phase 2·ketamine

Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression

Celon Pharma SA

Major Depressive Disorder
Completed·N/A·ketamine

Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine

Psych Atlanta

Treatment Resistant Depression
Completed·Phase 2·ketamine

Study of Ketamine for Depression in Cancer Patients Receiving Palliative Care

University Health Network, Toronto

DepressionCancerPalliative Care
Completed·Phase 3·ketamine

Trial of the Rapid Antisuicidal Effects of Intranasal Ketamine in Comorbid Depression and Alcohol Abuse

The University of Texas Health Science Center, Houston

Suicidal IdeationDepressionAlcohol Abuse
Completed·Phase 2·ketamine

Sequential Therapy for the Treatment of Severe Bipolar Depression.

NeuroRx, Inc.

Bipolar DepressionSuicidal IdeasSuicidal Ideation+1 more
Completed·Phase 1·psilocybin

Psilocybin-assisted Group Therapy for Demoralization in Long-term AIDS Survivors

Joshua Woolley

DistressDepressionGrief
Completed·Phase 1·ketamine

Intravenous Ketamine Plus Neurocognitive Training for Depression

Rebecca Price

Depression
Completed·Phase 4·ketamine

A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)

Massachusetts General Hospital

Depression
Completed·Phase 1·ketamine

Ketamine as an Adjunctive Therapy for Major Depression

St Patrick's Hospital, Ireland

Major Depressive EpisodeUnipolar DepressionBipolar Depression
Completed·Phase 2·psilocybin

Effects of Psilocybin in Major Depressive Disorder

Johns Hopkins University

Major Depressive Disorder
Completed·Phase 2·ketamine

ELEKT-D: Electroconvulsive Therapy (ECT) vs. Ketamine in Patients With Treatment Resistant Depression (TRD)

Bo Hu

Treatment Resistant DepressionElectroconvulsive TherapyECT+6 more
Completed·Phase 2·ketamine

Ketamine and Nitroprusside for Depression

Icahn School of Medicine at Mount Sinai

Depression
Completed·Phase 2·ketamine

Open Label Ketamine Treatment for Major Depressive Disorder in Veterans

VA Connecticut Healthcare System

Major Depressive Disorder
Completed·N/A·Other

Dance Movement Therapy in the Treatment of Depressed Patients: A Randomised Controlled Trial

University of Jyvaskyla

Depression
Completed·Early Phase 1·ketamine

Study of Oral Ketamine Versus Placebo for Treating Depression in Patients Undergoing Treatment for Cancer

Scott A. Irwin, MD, PhD

CancerDepression
Completed·Phase 2·ketamine

Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients

The University of Texas Health Science Center, Houston

Treatment Resistant Depression
Completed·Phase 2·ketamine

Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease

University Hospital, Lille

Depression
Completed·Phase 1·ketamine

Double-Blind Trial of Ketamine Therapy Plus or Minus Naltrexone in Treatment Resistant Depression (TRD)

Stanford University

Depression
Completed·N/A·Other

Neurocognitive Features of Patients With Treatment-Resistant Depression

Massachusetts General Hospital

Treatment Resistant Depression
Completed·Phase 2·ketamine

Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

VA Connecticut Healthcare System

Major Depressive DisorderAlcohol Use Disorder
Completed·N/A·ketamine

Cognitive Recovery After Electroconvulsive Therapy and General Anesthesia

Washington University School of Medicine

DepressionDeliriumSeizures+1 more
Completed·N/A·LSD

Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

St. Olavs Hospital

Depressive DisorderDepressive Disorder, Major
Completed·Phase 2·ketamine

Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects

Yale University

Depression
Completed·Phase 4·ketamine

Ketamine for Depression: An MRI Study

Massachusetts General Hospital

DepressionAnxious DepressionMajor Depressive Disorder
Completed·N/A·ketamine

Ketamine Anesthesia for Improvement of Depression in ECT

VA Puget Sound Health Care System

Major Depressive Disorder
Completed·Early Phase 1·ketamine

Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disorder or Bipolar Depression.

Sunnybrook Health Sciences Centre

Major Depressive DisorderBipolar I DisorderBipolar II Disorder+2 more
Completed·Phase 4·ketamine

Effects of Low-dose Ketamine as an Adjunct to Propofol-based Anesthesia for Electroconvulsive Therapy

University of Alberta

Depressive Disorder
Completed·Phase 4·ketamine

Ketamine Infusion for Adolescent Depression and Anxiety

Yale University

Major Depressive DisorderAnxiety Disorder
Completed·N/A·ketamine

Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression

The Cleveland Clinic

Treatment Resistant DepressionMajor Depressive DisorderSevere Depression
Completed·N/A·Other

Heart Rate Variability in Depression

Emory University

Major Depressive Disorder
Completed·Phase 2·ketamine

miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome

University of Alabama at Birmingham

Major Depressive Disorder
Completed·Early Phase 1·ketamine

Ketamine for Depression Relapse Prevention Following ECT

St Patrick's Hospital, Ireland

Depression
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.