24 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 100 of 170 trials
Withdrawn·Phase 2·ketamine
Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension Study
Zylorion Health
Treatment Resistant Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)
Sheppard Pratt Health System
Treatment Resistant Depression
Completed·Phase 4·ketamine
A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)
Massachusetts General Hospital
Depression
Unknown·N/A·ketamine
Ketamine Infusions for Major Depression Disorder
Sheba Medical Center
Depressive Disorder, Major
Recruiting·Phase 2·psilocybin
Does Psilocybin Require Psychedelic Effects to Treat Depression?
Centre for Addiction and Mental Health
Treatment-resistant Depression
Completed·Phase 4·ketamine
Ketamine for Older Adults Pilot
Washington University School of Medicine
Treatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more
Withdrawn·Phase 1·ketamine
A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Depression
Unknown·Phase 4·ketamine
D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression
Sheba Medical Center
Treatment Resistant Depression
Recruiting·Phase 2·ketamine
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
ACADIA Pharmaceuticals Inc.
Major Depressive Disorder (MDD)Depressive Disorder, Treatment-Resistant
Completed·Phase 3·ketamine
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
Janssen-Cilag, S.A.
Depression
Completed·N/A·ketamine
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression
Douglas Mental Health University Institute
Depressive Disorder, Treatment-ResistantDepressive Disorder, MajorUnipolar Depression+1 more
Unknown·Phase 3·ketamine
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression
Tel-Aviv Sourasky Medical Center
Suicidal IdeationMajor Depressive DisorderHealthy Participants
Completed·N/A·Other
Neurocognitive Features of Patients With Treatment-Resistant Depression
Massachusetts General Hospital
Treatment Resistant Depression
Completed·Phase 1·ketamine
Ketamine Trial for the Treatment of Depression
The University of New South Wales
Unipolar Depression
Completed·N/A·ketamine
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression
Centre for Addiction and Mental Health
Bipolar Disorder (BD)Suicidality
Completed·Phase 1·ketamine
KET-RO Plus RO DBT for Treatment Resistant Depression
Washington University School of Medicine
Treatment Resistant Depression
Withdrawn·Phase 4·ketamine
Ketamine Frequency Treatment for Major Depressive Disorder
Essentia Health
Treatment Resistant Depression
Completed·N/A·ketamine
Chart Review of Patients Undergoing Ketamine Treatments for Depression
Sunnybrook Health Sciences Centre
Depression - Major Depressive Disorder
Recruiting·Phase 1·ketamine
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
National Institute of Mental Health (NIMH)
DepressionMajor Depressive DisorderMajor Depression
Withdrawn·Phase 3·ketamine
ECT vs. Esketamine
Medical University Innsbruck
Treatment Resistant DepressionMajor Depressive Disorder
Unknown·N/A·ketamine
In Vitro Modeling of Drug-resistant Psychiatric Disorders Using Induced Pluripotent Cells
University of Milano Bicocca
Depressive Disorder, Treatment-Resistant
Recruiting·Phase 4·ketamine
ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression
University of Saskatchewan
Treatment Resistant DepressionKetamine
Completed·Phase 3·ketamine
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Treatment-resistant Depression
Withdrawn·Phase 1·ketamine
Intravenous Ketamine Effects on Functional Neuroanatomy
Neurological Associates of West Los Angeles
Depression
Completed·Phase 2·ketamine
Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression
VA Office of Research and Development
Treatment-resistant Depression
APPROVED_FOR_MARKETING·N/A·ketamine
Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)
Janssen Research & Development, LLC
Depressive Disorder, Treatment-Resistant
Completed·Phase 2·ketamine
A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression
Janssen Pharmaceutical K.K.
Depression
Completed·Phase 2·ketamine
A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD
Perception Neuroscience
Treatment Resistant Depression
Completed·N/A·ketamine
Pharmacogenetics Associated With IV Ketamine
Brain and Cognition Discovery Foundation
Treatment Resistant Depression
Completed·N/A·ketamine
Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Massachusetts General Hospital
Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
Major Depressive DisorderAnhedoniaTreatment Resistant Depression
Completed·Phase 2·psilocybin
The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression
COMPASS Pathways
Treatment Resistant Depression
Unknown·Phase 4·ketamine
Clinical Trial of the Use of Ketamine in Treatment Resistant Depression
National Institute of Neurology and Neurosurgery, Mexico
Depressive Disorder, Treatment-Resistant
Recruiting·Phase 2·psilocybin
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Centre for Addiction and Mental Health
Treatment Resistant DepressionChronic Pain
Completed·N/A·ketamine
A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders
Medical University of Gdansk
Treatment Resistant DepressionBipolar DepressionKetamine+1 more
Recruiting·Phase 2·ketamine
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
National Institute of Mental Health (NIMH)
SuicideDepressive Disorder, Treatment-ResistantKetamine+10 more
Completed·Phase 2·ketamine
Ketamine for Depression and Suicide Risk
Mayo Clinic
DepressionSuicide
Completed·N/A·Other
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
Dr.Yoav Domany
Treatment Resistant Depression (TRD)Depression - Major Depressive DisorderBipolar Depression
Recruiting·N/A·ketamine
ACT_for Alcohol Use Disorder and Depression
Centre hospitalier de l'Université de Montréal (CHUM)
Depression - Major Depressive DisorderAlcohol Use Disorder
Completed·Phase 2·ketamine
FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression
Brian Barnett
Bipolar DepressionTreatment Resistant Bipolar Depression
Terminated·Phase 2·ketamine
Intranasal Ketamine In the Treatment of Pediatric Bipolar Disorder
Juvenile Bipolar Research Foundation
Bipolar Disorder
Withdrawn·Phase 2·psilocybin
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD
Massachusetts General Hospital
Treatment-Resistant Major Depressive Disorder
Not Yet Recruiting·Phase 3·psilocybin
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
VA Office of Research and Development
Major Depression
Completed·Phase 4·ketamine
Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression
Taipei Veterans General Hospital, Taiwan
Treatment-resistant DepressionMajor Depressive Disorder
Terminated·N/A·Other
Anesthesia and Functional Connectivity: An Analysis of fMRI Changes
University of Michigan
Changes in Brain Network Connectivity
Completed·Phase 2·MDMA
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
Lykos Therapeutics
Posttraumatic Stress Disorder
Completed·Phase 4·ketamine
Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression
Maimonides Medical Center
Treatment Resistant DepressionMajor Depressive DisorderAnalgesia+10 more
Unknown·Phase 2·ketamine
Ketamine for Treatment-resistant Depression: A Multicentric Clinical Trial in Mexican Population
Paul J. Lamothe
Depressive Disorder,Treatment-Resistant Depression
Recruiting·Phase 3·psilocybin
Psilocybin-Assisted Therapy in Treatment-Resistant Depression
University of North Carolina, Chapel Hill
Refractory DepressionTreatment Resistant Depression
Recruiting·Phase 2·psilocybin
Psilocybin for Hospitalized Patients with Treatment-resistant Depression
University Hospital, Ghent
Treatment Resistant Depression
Recruiting·Phase 4·ketamine
A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression
Janssen Korea, Ltd., Korea
Depressive Disorder, Treatment-Resistant
Unknown·N/A·ketamine
Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide
Taipei Veterans General Hospital, Taiwan
Major Depressive Disorder
Completed·Phase 2·psilocybin
The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation
Sheppard Pratt Health System
Treatment Resistant DepressionSuicidal Ideation
Recruiting·N/A·Other
Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
Unity Health Toronto
Major Depressive Disorder (MDD)Major Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Not Yet Recruiting·Phase 1·ketamine
Ketamine Biomarker Validation
Soterix Medical
Treatment Resistant Depression (TRD)
Completed·N/A·psilocybin
Psilocybin-assisted Interpersonal Therapy for Depression
University of Otago
Depressive Disorder, Treatment-Resistant
Completed·N/A·ketamine
Intranasal Ketamine in Ultra-REsistant Depression (SURE-ECT Non Responders)
Centre for Addiction and Mental Health
Depression
Active, Not Recruiting·Early Phase 1·ketamine
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
Mayo Clinic
Major Depressive DisorderTreatment Resistant DepressionBipolar Depression
Completed·N/A·ketamine
Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine
Psych Atlanta
Treatment Resistant Depression
Completed·Phase 1·ketamine
A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers
BrainCells Inc.
Healthy
Completed·N/A·ketamine
Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality
Assiut University
Treatment Resistant Depression
Not Yet Recruiting·Phase 2·ketamine
Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression
University of Rochester
Treatment Resistant Depression (TRD)Chronic Pain
Completed·N/A·ketamine
Treatment Resistant Depression (Pilot)
Washington University School of Medicine
Depressive Disorder, Treatment-Resistant
Withdrawn·Phase 2·Other
Efficacy and Safety of TAK-653 in Treatment-Resistant Depression
Millennium Pharmaceuticals, Inc.
Treatment-Resistant Depression
Withdrawn·Phase 4·ketamine
VA Aripiprazole vs Esketamine for Treatment Resistant Depression
VA Office of Research and Development
Depressive Disorder, Major
Recruiting·N/A·ketamine
Belief Updating in Treatment Resistant Depression
Assistance Publique - Hôpitaux de Paris
Treatment Resistant Depression
Completed·Phase 2·ketamine
Action of Ketamine in Treatment-Resistant Depression
University of Ottawa
Treatment-resistant Depression
Completed·N/A·psilocybin
Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression
Centre Hospitalier Universitaire de Nīmes
Depressive DisorderDepressive Disorder, Treatment-ResistantHallucinogens+1 more
Recruiting·Phase 3·ketamine
The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment.
Dr. Inge Winter
Major Depressive DisorderTreatment Resistant Depression
Completed·Phase 2·psilocybin
Psilocybin for Treatment-Resistant Depression
Brain and Cognition Discovery Foundation
Treatment Resistant Depression
Completed·Phase 1·ketamine
Rapid Antidepressant Effects of Ketamine in Major Depression
National Institute of Mental Health (NIMH)
DepressionMood DisordersMajor Depresssion
Completed·Phase 3·ketamine
A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder
Janssen-Cilag International NV
Depressive Disorder, Major
Recruiting·Phase 2·ketamine
Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression
Joshua Rosenblat
Bipolar DisorderBipolar DepressionBipolar I Disorder+1 more
Completed·Phase 3·ketamine
A Study to Evaluate the Efficacy, Safety, and Tolerability of Fixed Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Treatment-resistant Depression
Not Yet Recruiting·Phase 3·ketamine
Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly Patients
Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Depressive Disorder
Unknown·Phase 3·ketamine
Evaluation of Schemes of Administration of Intravenous Ketamine in Depression
National Institute of Neurology and Neurosurgery, Mexico
Treatment Resistant Depression
Not Yet Recruiting·Phase 2·psilocybin
Efficacy of Psilocybin and Trazodone Combination in Treatment-resistant Depression: a Randomized Controlled Proof-of-concept Study (PSILOTRAZ)
Centre Hospitalier St Anne
Depression - Major Depressive DisorderTreatment-resistant Depression (TRD)
Completed·N/A·Other
Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)
COMPASS Pathways
Treatment Resistant Depression
Recruiting·Phase 1·ketamine
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Baylor College of Medicine
HealthyMajor Depressive DisorderTreatment Resistant Depression
Recruiting·N/A·ketamine
Long-term Observation of Participants With Mood Disorders
National Institute of Mental Health (NIMH)
DepressionSuicide Risk
Completed·Phase 3·ketamine
Ketamine for Treatment Resistant Late-Life Depression
VA Office of Research and Development
Treatment Resistant Depressive Disorder
Completed·Phase 4·ketamine
A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Depressive Disorder, Treatment-Resistant
Terminated·Phase 4·ketamine
N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major Depression
Massachusetts General Hospital
Major Depressive Disorder
Completed·Phase 2·ketamine
Low Dose Intravenous Ketamine in Treatment Resistant Depression Patients
The University of Texas Health Science Center, Houston
Treatment Resistant Depression
Terminated·Phase 2·ketamine
The UTHealth Ketamine Project
The University of Texas Health Science Center, Houston
Treatment Resistant DepressionMajor Depressive DisorderBipolar Disorder
Completed·Phase 2·ketamine
Efficacy, Safety and Pharmacokinetic Study of Inhaled Esketamine in Treatment-resistant Depression
Celon Pharma SA
Major Depressive Disorder
Completed·Phase 2·DMT
A Trial of GH001 in Patients With Treatment-resistant Depression
GH Research Ireland Limited
Treatment-resistant Depression
Completed·Phase 4·ketamine
A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment
Janssen-Cilag Ltd.
Depressive Disorder, Major
Completed·N/A·ketamine
MRI Studies of Emotion in Depression
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Unknown·Phase 2·psilocybin
The Safety and Efficacy of Psilocybin in Participants With Type 2 Bipolar Disorder (BP-II) Depression.
Sheppard Pratt Health System
Treatment Resistant Depression
Recruiting·Phase 4·ketamine
Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression
The George Institute
Treatment Resistant Depression
Completed·Early Phase 1·ketamine
Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine
King's College London
Depressive Disorder, Treatment-Resistant
Not Yet Recruiting·Phase 3·ketamine
InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression
Sunnybrook Health Sciences Centre
Treatment Resistant Depression
Completed·Phase 3·ketamine
A Study of Intranasal Esketamine Plus an Oral Antidepressant for Relapse Prevention in Adult Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Depressive Disorder, Treatment-Resistant
Active, Not Recruiting·Phase 3·psilocybin
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
COMPASS Pathways
Treatment Resistant Depression
Completed·Phase 2·ketamine
A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression
Janssen Research & Development, LLC
Major Depressive Disorder
Recruiting·N/A·ketamine
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
Treatment Resistant DepressionMajor Depressive EpisodeMajor Depression+4 more
Completed·N/A·ketamine
Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant Depression
The Cleveland Clinic
Treatment Resistant DepressionMajor Depressive DisorderSevere Depression
Withdrawn·Phase 2·ketamine
Effect of Lithium Versus Placebo in Adults With Treatment-Resistant Depression Who Are Receiving Ketamine
William V. Bobo, M.D.
Treatment Resistant Depression
Recruiting·Phase 2·ketamine
Intravenous Ketamine for Treatment-Resistant Depression
Mayo Clinic
Depressive Disorder, Treatment-ResistantTreatment Resistant Depression (TRD)
More trials available. Refine your search to see specific results.
How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.