Active, Not RecruitingPhase 1psilocybin

Comparing the Effects of Psilocin and Psilocybin in Healthy Adults

NCT ID

NCT05317689

Target Enrollment

20 participants

Start Date

2022-05-26

Est. Completion

2025-07

About This Study

To compare the physiological and psychological effects of psilocin taken orally by pill or sublingually by dissolving a tablet under the tongue to those of psilocybin taken by pill in healthy adults.

Conditions Studied

Healthy

Interventions

•Psilocin
•Psilocybin
•Sublingual Psilocin

Eligibility

Age:25 Years - 50 Years

Healthy Volunteers:Yes

View full eligibility criteria

Inclusion Criteria:

* Age 25 to 50
* Comfortable speaking and writing in English
* Commit to attending all study visits and remote data collection tasks
* No planned surgeries during the study
* Had at least one prior experience with a psychedelic substance
* Generally mentally and physically healthy
* Agree to abstain from THC, CBD, or nicotine products during study

Exclusion Criteria:

* Participated in another clinical trial within 30 days of entry to this trial
* Regular use of medications that may have problematic interactions with psilocybin, including but not limited to dopamine agonists, MAO inhibitors, N-methyl-D-aspartate (NMDAR) antagonists, antipsychotics, and stimulants
* A health condition that makes study unsafe or unfeasible, determined by study physicians

Study Locations (1)

University of California, San Francisco