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Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 1–48 of 1695 trials
Active, Not Recruiting·Phase 3·LSD
A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge)
Definium Therapeutics US, Inc.
Major Depressive Disorder
Active, Not Recruiting·Early Phase 1·ketamine
Evaluation of Ketamine/Midazolam Sedation vs. Fentanyl/Midazolam Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology
CAMC Health System
SedationInterventional RadiologyBiopsy+1 more
Active, Not Recruiting·N/A·psilocybin
Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism
Healing Advocacy Fund
Alcohol Use Disorder
Active, Not Recruiting·Phase 4·ketamine
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
Stanford University
Chronic PainDepression
Active, Not Recruiting·N/A·ketamine
Link Between Reduction of Suicide Ideation by Esketamine in Add-On and Initial Levels of Psychological Pain and Anhedonia
University Hospital, Montpellier
Depression - Major Depressive DisorderDepression DisorderSuicide
Active, Not Recruiting·Phase 2·ketamine
Single-dose Ketamine Treatment to Improve Depression in Mild Cognitive Impairment
Icahn School of Medicine at Mount Sinai
DepressionMild Cognitive Impairment
Active, Not Recruiting·Early Phase 1·MDMA
MDMA-Assisted Therapy for Pathological Narcissism
University of Washington
Narcissism
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
Major Depressive DisorderAnhedoniaTreatment Resistant Depression
Active, Not Recruiting·Phase 1·psilocybin
A Study of Psilocybin for PTSD
Johns Hopkins University
Post Traumatic Stress Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer
University Health Network, Toronto
Advanced CancerStage IV Solid Tumor CancerStage IV Sarcoma of Bone+3 more
Active, Not Recruiting·Phase 2·DMT
A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder (GAD)
Cybin IRL Limited
Generalized Anxiety Disorder
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
Peggy C Nopoulos
Alcohol Use Disorder
Active, Not Recruiting·Phase 2·psilocybin
Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
TRYP Therapeutics
Irritable Bowel Syndrome
Active, Not Recruiting·Phase 2·psilocybin
Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive Impairment
Centre for Addiction and Mental Health
Amnestic Mild Cognitive Impairment
Active, Not Recruiting·Early Phase 1·LSD
LSD Occupancy of the Serotonin 2A Receptor in the Human Brain
Rigshospitalet, Denmark
Basic Science
Active, Not Recruiting·Phase 1·psilocybin
Neural and Physiological Correlates of Psychedelic Sub-states
Robin Carhart-Harris, PhD, MA
Psychedelic ExperiencesNeuroimagingHealthy Volunteers
Active, Not Recruiting·Phase 1·psilocybin
Effects of Repeated Psilocybin Dosing in OCD
Yale University
Obsessive-Compulsive Disorder
Active, Not Recruiting·N/A·Other
Early Versus Late Ofatumumab (Kesimpta®) Use in Austrian RMS-Patients Over 2 Years
Novartis Pharmaceuticals
Relapsing Multiple Sclerosis
Active, Not Recruiting·Phase 1·psilocybin
Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers
University of Nebraska
Pancreas CancerBiliary Tract CancerPsychological Distress+1 more
Active, Not Recruiting·Phase 2·ketamine
Glutamatergic Modulation as a Treatment for Depressive Symptoms Among Patients With Post-acute Sequelae of COVID (PASC): A Pilot Trial
New York State Psychiatric Institute
Post-acute Sequelae of COVID-19Depressive SymptomsCognitive Dysfunction
Active, Not Recruiting·Phase 1·psilocybin
Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder
University of Wisconsin, Madison
Methamphetamine Use DisorderSubstance-Related DisordersChemically-Induced Disorders+2 more
Active, Not Recruiting·Phase 3·psilocybin
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
COMPASS Pathways
Treatment Resistant Depression
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study
Anders Fink-Jensen, MD, DMSci
Alcohol Use Disorder (AUD)
Active, Not Recruiting·Phase 2·psilocybin
A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder
COMPASS Pathways
Major Depressive Disorder
Active, Not Recruiting·Phase 3·psilocybin
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
COMPASS Pathways
Treatment Resistant Depression
Active, Not Recruiting·Phase 1·DMT
Single and Repeat Doses of DMT in Healthy Subjects
Algernon Pharmaceuticals
Stroke
Active, Not Recruiting·Phase 2·ketamine
Ketamine for Multiple Sclerosis Fatigue
Johns Hopkins University
Multiple Sclerosis Fatigue
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
PTSDStress Disorders, TraumaticStress Disorders, Post-Traumatic+2 more
Active, Not Recruiting·Early Phase 1·psilocybin
Effects of Psilocybin in Obsessive Compulsive Disorder
Johns Hopkins University
Obsessive-Compulsive Disorder
Active, Not Recruiting·Phase 1·psilocybin
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
Eleusis Therapeutics
Healthy VolunteersMajor Depressive DisorderDepression
Active, Not Recruiting·Phase 1·psilocybin
Comparing the Effects of Psilocin and Psilocybin in Healthy Adults
University of California, San Francisco
Healthy
Active, Not Recruiting·Phase 4·ketamine
Ketamine-Assisted Mindfulness-Based Cognitive Therapy for Depression: A Pilot Study
Ohio State University
Major Depressive Disorder
Active, Not Recruiting·Phase 4·ketamine
Ketamine and Kidney Injury in Cardiac Surgery
Mayo Clinic
Cardiac Surgery
Active, Not Recruiting·Phase 4·DMT
A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation
Novartis Pharmaceuticals
Relapsing-Remitting Multiple Sclerosis
Active, Not Recruiting·N/A·Other
Covid-19 Vaccine Immune Response in Multiple Sclerosis
University Hospitals of North Midlands NHS Trust
Multiple Sclerosis
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin Therapy for Depression in Bipolar II Disorder
University of California, San Francisco
Bipolar II Disorder
Active, Not Recruiting·Phase 3·ketamine
Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
NYU Langone Health
Chronic Postsurgical Pain
Active, Not Recruiting·N/A·ibogaine
Pre-post Evaluation of the Safety and Efficacy of Ibogaine-Magnesium Therapy in Veterans With Repeated Blast Exposure
Stanford University
Blast or Combat ExposureHead Injury Trauma
Active, Not Recruiting·N/A·psilocybin
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin
King's College London
Depression - Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
Johns Hopkins University
Major Depressive DisorderAlcohol Use Disorder
Active, Not Recruiting·Phase 4·ketamine
Ketamine vs Lidocaine in Traumatic Rib Fractures
Brittany Hoyte
Rib FracturesRib Fracture MultipleRib Trauma
Active, Not Recruiting·Phase 1·DMT
Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
Yale University
Major Depressive DisorderDepression
Active, Not Recruiting·N/A·DMT
A Study to Evaluate the Safety of Ozanimod Exposure During Pregnancy in Women With Multiple Sclerosis and Their Infants
Bristol-Myers Squibb
Multiple Sclerosis
Active, Not Recruiting·Phase 4·ketamine
Ketamine + Cognitive Training for Suicidality in the Medical Setting
Rebecca Price
Suicide, Attempted
Active, Not Recruiting·Phase 2·psilocybin
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)
Sheppard Pratt Health System
Treatment Resistant Depression
Active, Not Recruiting·Phase 2·psilocybin
Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder
Keith Heinzerling
Alcohol Use Disorder
Active, Not Recruiting·N/A·ketamine
Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia
Wilderman Medical Clinic
Fibromyalgia
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Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.