24 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 100 of 113 trials
Completed·Phase 2·MDMA
MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD
VA Loma Linda Health Care System
Post Traumatic Stress DisorderCombat Stress Disorders
Unknown·Phase 2·psilocybin
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSD
Apex Labs Ltd.
Post-traumatic Stress DisorderDepression
Completed·Phase 1·ketamine
Ketamine and Prolonged Exposure in PTSD
Minneapolis Veterans Affairs Medical Center
Post-traumatic Stress Disorder
Completed·Phase 1·ketamine
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
Yale University
Depressive Disorder, MajorPost Traumatic Stress DisorderBipolar Disorder
Not Yet Recruiting·Phase 2·MDMA
MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers
Nautilus Sanctuary
Post-Traumatic Stress DisorderAdjustment Disorders
Recruiting·Phase 2·ketamine
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
Depressive DisorderMajor Depressive DisorderBipolar Disorder+2 more
Not Yet Recruiting·Phase 1·ketamine
Ketamine Assisted Psychotherapy for Treating Comorbid Chronic Pain and PTSD
Queen's University
Chronic PainPosttraumatic Stress Disorder (PTSD)
Recruiting·Phase 4·ketamine
The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD
Margaux M. Salas, PhD
Neuropathic PainPTSD
Completed·Phase 2·ketamine
Ketamine as a Treatment for Post-Traumatic Stress Disorder (PTSD)
Icahn School of Medicine at Mount Sinai
Posttraumatic Stress Disorder (PTSD)
Withdrawn·Phase 2·MDMA
MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents
University of California, Los Angeles
PTSD, Post Traumatic Stress DisorderAdolescentsPsychotherapy
Completed·Phase 2·MDMA
Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)
Lykos Therapeutics
Posttraumatic Stress Disorder
Completed·Phase 3·ketamine
Ketamine Infusion for Comorbid PTSD and Chronic Pain
VA Ann Arbor Healthcare System
PTSDChronic Pain
Completed·N/A·ketamine
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
Defense and Veterans Center for Integrative Pain Management
Pain, AcuteAnalgesiaAmputation, Traumatic+2 more
Completed·N/A·MDMA
Exploring Mechanisms of Action in MDMA-assisted Psychotherapy for PTSD
Lykos Therapeutics
Posttraumatic Stress Disorder
Recruiting·Phase 2·MDMA
MDMA for AUD/PTSD Comorbidity
Carolina L Haass-Koffler
Alcohol Use DisorderPost Traumatic Stress Disorder
Unknown·Phase 2·psilocybin
Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress Disorder
Halucenex Life Sciences Inc.
Treatment Resistant DisordersPost Traumatic Stress Disorder
Not Yet Recruiting·Phase 2·psilocybin
Mindfulness-based Psilocybin Therapy for PTSD
Anthony P King
Post Traumatic Stress DisorderDepression - Major Depressive Disorder
Withdrawn·Phase 1·ketamine
Connectivity Changes Associated With Ketamine Assisted Psychotherapy for PTSD
University of New Mexico
PTSD
Withdrawn·Phase 2·ibogaine
Trifecta Research Study
Johns Hopkins University
PTSD - Post Traumatic Stress DisorderCognitive DysfunctionBrain Trauma+1 more
Recruiting·Phase 2·ketamine
Ketamine, SGB and Combination Treatment for TBI
Northwestern University
Posttraumatic HeadachePosttraumatic Stress Disorder
Terminated·Phase 2·ketamine
Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy
Yale University
Posttraumatic Stress Disorder
Completed·Phase 3·MDMA
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)
Lykos Therapeutics
Posttraumatic Stress Disorder
Recruiting·Phase 2·ketamine
Enhancing Week-long Psychological Treatment for PTSD With Ketamine
Yale University
Posttraumatic Stress Disorder
Terminated·Phase 4·ketamine
RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain
Johns Hopkins University
Acute PainWound CarePosttraumatic Stress Disorder
Completed·N/A·ketamine
Chart Review of Patients Undergoing Ketamine Infusions
Brain and Cognition Discovery Foundation
Major Depressive DisorderBipolar DisorderObsessive-Compulsive Disorder+1 more
Completed·Phase 3·MDMA
A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)
Lykos Therapeutics
Posttraumatic Stress Disorder
Completed·Phase 2·ketamine
CAP-Ketamine for Antidepressant Resistant PTSD
VA Office of Research and Development
PTSDPosttraumatic Stress Disorder
Completed·Phase 1·MDMA
Group MDMA-therapy for Veterans With PTSD
Portland VA Research Foundation, Inc
PTSD
Terminated·Phase 2·MDMA
Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD
Lykos Therapeutics
PTSD
Not Yet Recruiting·Phase 2·ketamine
Ketamine Treatment for PTSD and MDD in TBI
Minneapolis Veterans Affairs Medical Center
PTSD, Post Traumatic Stress DisorderMajor Depressive DisorderTraumatic Brain Injury
Completed·N/A·ketamine
Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics
Klarisana Physician Services PLLC
Stress Disorders, Post-TraumaticAnxiety Disorders
Completed·Phase 2·ketamine
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Dennis Charney
Stress Disorders, Post-TraumaticPTSDDepression+1 more
Withdrawn·Phase 1·MDMA
The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.
Yale University
Post Traumatic Stress Disorder
Recruiting·Phase 2·MDMA
Dose Optimization of MDMA-Assisted Therapy for PTSD
Bronx VA Medical Center
Posttraumatic Stress Disorder
Not Yet Recruiting·Phase 3·psilocybin
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
VA Office of Research and Development
Major Depression
NO_LONGER_AVAILABLE·N/A·MDMA
A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTSD
Lykos Therapeutics
Post Traumatic Stress Disorder
Enrolling by Invitation·N/A·ketamine
Intraoperative Subanesthetic Ketamine Versus Dexmedetomidine Infusion for Prevention of Post-traumatic Stress Disorder After Traumatic Brain Surgeries
Zagazig University
Subanesthetic Ketamine Dexmedetomidin
Completed·Phase 2·MDMA
Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD
Lykos Therapeutics
Posttraumatic Stress Disorder
Recruiting·Phase 1·psilocybin
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)
Johns Hopkins University
Posttraumatic Stress Disorder
Recruiting·N/A·psilocybin
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
OCDMajor Depressive Disorder (MDD)Alcohol Use Disorder (AUD)+8 more
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD
Unity Health Toronto
Post Traumatic Stress DisorderPTSDChronic PTSD
Completed·Phase 3·psilocybin
Frontline Clinician Psilocybin Study
University of Washington
Burnout, CaregiverBurnout, ProfessionalCOVID-19+3 more
Terminated·Phase 2·MDMA
Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSD
Lykos Therapeutics
Posttraumatic Stress Disorder
Withdrawn·Phase 2·ketamine
To Test the Potential Efficacy of Repeated Intranasal Administration of Ketamine as a Treatment for PTSD
Adriana Feder
PTSD
Completed·Phase 2·ketamine
Ketamine-enhanced Prolonged Exposure Therapy in PTSD
VA Office of Research and Development
PTSD
Recruiting·Phase 2·ketamine
Ayahuasca, Esketamine and PTSD
University of Sao Paulo
Posttraumatic Stress Disorder (PTSD)
Withdrawn·Phase 2·MDMA
Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in Veterans
Lykos Therapeutics
PTSD
Unknown·Phase 1·ketamine
The Effect of Intravenous Ketamine on Non Suicidal Self Injuries.
Tel-Aviv Sourasky Medical Center
Non Suicidal Self Injury
Unknown·N/A·MDMA
Sustaining Remission From PTSD Using Tuned Vibroacoustic Stimulation (TVS) Following MDMA-Assisted Psychotherapy
Apollo Neuroscience, Inc.
Stress Disorders, Post-Traumatic
Active, Not Recruiting·N/A·psilocybin
Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment
University Hospital, Geneva
Major Depressive Disorder (MDD)Anxiety DisordersSubstance Use Disorder (SUD)+1 more
Completed·N/A·ketamine
PET Imaging of mGLuR5 With Drug Challenge
Yale University
Major Depressive DisorderPost-Traumatic Stress Disorder (PTSD)
Recruiting·Phase 2·MDMA
MDMA for Co-occurring PTSD and OUD After Childbirth
University of New Mexico
Stress Disorders, Post-TraumaticOpioid Use Disorder
Enrolling by Invitation·N/A·ketamine
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)
Medical University of Gdansk
Major Depressive DisorderPost Traumatic Stress DisorderObsessive-Compulsive Disorder+3 more
Recruiting·N/A·ketamine
Imaging SV2A in Mood Disorders
Yale University
Major Depressive DisorderPost-Traumatic Stress Disorder
Enrolling by Invitation·N/A·ketamine
Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric Interventions
Psyrin Inc.
Obsessive Compulsive Disorder (OCD)Bipolar DisordersMajor Depressive Disorder+2 more
Recruiting·Phase 2·MDMA
MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder
Stephen Robert Marder
Post Traumatic Stress Disorder
Recruiting·Phase 4·ketamine
Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients
Texas Tech University Health Sciences Center
Orthopedic Trauma Surgery PatientsPostoperative PainOpioid Use+2 more
Enrolling by Invitation·Phase 2·MDMA
MDMA Plus Exposure Therapy for PTSD
Emory University
PTSD
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Randomized Therapy
Emory University
PTSD
Completed·Phase 2·MDMA
Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial
Lykos Therapeutics
Posttraumatic Stress Disorder
Enrolling by Invitation·N/A·ketamine
Effect of Ketamine and Etomidate During RSI on Long Term Outcomes
Vanderbilt University Medical Center
Post-Traumatic Stress DisorderAcute Respiratory Failure
Completed·Phase 2·MDMA
Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder
Lykos Therapeutics
Posttraumatic Stress Disorder
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Therapy for Sexual Assault-Related PTSD
Sunstone Medical
Post Traumatic Stress DisorderPTSD
Not Yet Recruiting·Phase 2·Other
Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002
Global Coalition for Adaptive Research
Post Traumatic Stress Disorder
Completed·Phase 2·MDMA
A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD)
Remedy
Post Traumatic Stress Disorder
Recruiting·Phase 2·psilocybin
Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)
Nathan Brashares Sackett
Alcohol Use Disorder (AUD)PTSD
Completed·Phase 2·ketamine
Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD
Icahn School of Medicine at Mount Sinai
PTSD
Completed·Phase 1·ketamine
Ketamine Infusions for PTSD and Treatment-Resistant Depression
Minneapolis Veterans Affairs Medical Center
Depressive Disorder, Treatment-ResistantStress Disorders, Post-Traumatic
Withdrawn·Phase 1·psilocybin
Safety and Tolerability of Psilocybin in Post-Traumatic Stress Disorder
Johns Hopkins University
Post-Traumatic Stress Disorder
Recruiting·Phase 2·MDMA
MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder
University of Sydney
PTSDAlcohol Use DisorderAlcohol Dependence+2 more
Completed·Phase 1·ketamine
Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)
The University of Texas Health Science Center at San Antonio
Post Traumatic Stress Disorder PTSD
Completed·Phase 3·MDMA
A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD
Lykos Therapeutics
PTSD
Completed·N/A·MDMA
Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD
Albany Research Institute, Inc.
Post Traumatic Stress Disorder
Unknown·Phase 3·MDMA
Epigenetics and MDMA-Assisted Psychotherapy for PTSD
University of Southern California
PTSD
Completed·Phase 2·MDMA
Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSD
Lykos Therapeutics
Posttraumatic Stress Disorder (PTSD)
Recruiting·Phase 1·psilocybin
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
TransdiagnosticDepression - Major Depressive DisorderAnxiety+5 more
Unknown·N/A·ketamine
TIMBER Psychotherapy and Ketamine Single Infusion in Chronic PTSD
The Cooper Health System
PTSD
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
PTSDStress Disorders, TraumaticStress Disorders, Post-Traumatic+2 more
Recruiting·Phase 2·MDMA
MDMA-Assisted CBCT for PTSD vs CBCT RCT
Remedy
Post Traumatic Stress Disorder
Completed·Phase 2·MDMA
Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD
Lykos Therapeutics
PTSD
Completed·N/A·MDMA
Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSD
Lykos Therapeutics
PTSD
Active, Not Recruiting·Phase 1·psilocybin
A Study of Psilocybin for PTSD
Johns Hopkins University
Post Traumatic Stress Disorder
Completed·Phase 2·psilocybin
The Safety and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder
COMPASS Pathways
Post Traumatic Stress Disorder
Unknown·Phase 2·ketamine
Ketamine and Epigenetic Aging
TruDiagnostic
DepressionPost Traumatic Stress Disorder
Unknown·Phase 1·ketamine
Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy
Southern California Institute for Research and Education
Healthy
Recruiting·N/A·ketamine
RIVER At Home Ketamine Protocols
RIVER Foundation
Chronic ConditionChronic PainChronic Disease+3 more
Completed·N/A·ketamine
Ketamine Infusion Therapy for PTSD in Combat Veterans
Klarisana Physician Services PLLC
Stress Disorders, Post-Traumatic
Unknown·Phase 2·ketamine
Combined Ketamine and eCBT Intervention for PTSD
Queen's University
Post-Traumatic Stress Disorder
Suspended·Early Phase 1·ketamine
Ketamine-assisted Psychotherapy for Adolescent PTSD (KAP)
University of Wisconsin, Madison
Posttraumatic Stress Disorder
Terminated·Phase 2·MDMA
Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel
Lykos Therapeutics
Posttraumatic Stress Disorder
Unknown·N/A·ketamine
Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort
Stella Center
Post-Traumatic Stress DisorderTraumatic Brain Injury
Unknown·Phase 2·MDMA
Preliminary Effectiveness of Individual and Group MDMA-assisted Therapy for Israeli Veterans With PTSD and Moral Injury.
HaEmek Medical Center, Israel
Post Traumatic Stress DisorderMoral InjuryMDMA ('Ecstasy')
Unknown·Phase 1·psilocybin
Northwest Therapies Trauma Psilocybin Study Compassionate Use Study
NWTraumatherapies
Trauma, Nervous System
Completed·Phase 4·ketamine
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health
Field Trip Health
DepressionAnxietyPost Traumatic Stress Disorder
Completed·Phase 3·MDMA
MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD
Dr. Leslie Morland
PTSDRelational Problems
Completed·Phase 2·MDMA
MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder
Lykos Therapeutics
Posttraumatic Stress Disorder
Completed·Phase 1·ketamine
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
University of Minnesota
Post-Traumatic Stress DisordersMajor Depressive Disorder
Recruiting·Phase 3·MDMA
MDMA-assisted Massed Prolonged Exposure for PTSD
Healing Breakthrough
Post-Traumatic Stress Disorder
Withdrawn·Phase 2·MDMA
Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD
Lykos Therapeutics
Posttraumatic Stress Disorder
Recruiting·Phase 2·psilocybin
State-Funded Trial Assessing Recovery and Long-Term Impact of Guided Psilocybin for Healing Trauma
Baylor College of Medicine
PTSD
More trials available. Refine your search to see specific results.
How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.