24 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 100 of 259 trials
Withdrawn·Phase 2·ketamine
Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension Study
Zylorion Health
Treatment Resistant Major Depressive Disorder
Withdrawn·Phase 3·ketamine
Endogenous Opioid Modulation by Ketamine
University of Utah
Major Depressive Disorder
Completed·N/A·ketamine
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
Yale University
Depression and Suicide
Completed·Phase 2·ketamine
A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide
Janssen Research & Development, LLC
Major Depressive Disorder
Completed·Phase 1·ketamine
Ketamine + Mindfulness for Depression
Rebecca Price
Depression, Unipolar
Unknown·Phase 2·psilocybin
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSD
Apex Labs Ltd.
Post-traumatic Stress DisorderDepression
Recruiting·Phase 1·ketamine
Imaging Neural Correlates of Ketamine Using PET/MR
Medical University of Vienna
Major Depressive Disorder
Recruiting·Phase 4·ketamine
Positioning of Esketamine Treatment in the Real-world Management of Depression
Royal North Shore Hospital
Major Depressive Disorder
Completed·Phase 1·psilocybin
Psilocybin-assisted CBT for Depression
University of California, Los Angeles
Major Depressive Disorder
Unknown·N/A·ketamine
Ketamine Infusions for Major Depression Disorder
Sheba Medical Center
Depressive Disorder, Major
Unknown·Phase 1·ketamine
Study of Ketamine as an Antidepressant in Major Depressive Disorder
Shi Jinyun
Major Depressive Disorder
Completed·Phase 1·ketamine
Biomarkers of Fast Acting Therapies in Major Depression
University of California, Los Angeles
Major Depressive Disorder
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Completed·Phase 1·ketamine
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
Yale University
Depressive Disorder, MajorPost Traumatic Stress DisorderBipolar Disorder
Completed·Phase 1·ketamine
Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
VA Office of Research and Development
Major Depressive DisorderAlcohol Use Disorder
Recruiting·Phase 2·ketamine
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
ACADIA Pharmaceuticals Inc.
Major Depressive Disorder (MDD)Depressive Disorder, Treatment-Resistant
Recruiting·Phase 4·ketamine
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
Massachusetts General Hospital
Major Depressive Disorder
Completed·Phase 3·ketamine
Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six Weeks
University Hospital, Grenoble
Major Depressive Disorder
Completed·N/A·ketamine
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression
Douglas Mental Health University Institute
Depressive Disorder, Treatment-ResistantDepressive Disorder, MajorUnipolar Depression+1 more
Unknown·Phase 3·ketamine
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression
Tel-Aviv Sourasky Medical Center
Suicidal IdeationMajor Depressive DisorderHealthy Participants
Recruiting·Phase 2·ketamine
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
Depressive DisorderMajor Depressive DisorderBipolar Disorder+2 more
Completed·Phase 1·ketamine
Ketamine Trial for the Treatment of Depression
The University of New South Wales
Unipolar Depression
Unknown·Phase 4·ketamine
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
University of Manitoba
Depression
Completed·Phase 1·ketamine
KET-RO Plus RO DBT for Treatment Resistant Depression
Washington University School of Medicine
Treatment Resistant Depression
Withdrawn·Phase 4·ketamine
Ketamine Frequency Treatment for Major Depressive Disorder
Essentia Health
Treatment Resistant Depression
Completed·N/A·Other
Characterization of the Prosocial and Prosexual Effects of GHB
University of Zurich
Depressive Disorder, MajorBipolar DisorderAutistic Disorder
Completed·N/A·ketamine
Chart Review of Patients Undergoing Ketamine Treatments for Depression
Sunnybrook Health Sciences Centre
Depression - Major Depressive Disorder
Recruiting·Phase 1·ketamine
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
National Institute of Mental Health (NIMH)
DepressionMajor Depressive DisorderMajor Depression
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
Yale University
Major Depressive Disorder
Recruiting·Phase 3·ketamine
Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting
Theresa Jacob, PhD, MPH
Severe DepressionModerate DepressionKetamine+16 more
Withdrawn·Phase 3·ketamine
ECT vs. Esketamine
Medical University Innsbruck
Treatment Resistant DepressionMajor Depressive Disorder
Completed·Phase 4·ketamine
Ketamine in the Treatment of Suicidal Depression
New York State Psychiatric Institute
Major Depressive DisorderSuicidal Ideation
Recruiting·Phase 3·psilocybin
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
Cybin IRL Limited
Major Depressive Disorder
Recruiting·Phase 3·psilocybin
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
Major Depressive Disorder (MDD)Depression in AdultsDepression - Major Depressive Disorder+3 more
Completed·Phase 4·ketamine
Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department
MercyOne Des Moines Medical Center
DepressionDepression SevereDepression Acute+2 more
Terminated·Phase 2·ketamine
A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive Disorder
Janssen Research & Development, LLC
Major Depressive Disorder
Terminated·N/A·ketamine
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
James Murrough
Major DepressionBipolar Depression
Not Yet Recruiting·Phase 2·psilocybin
Mindfulness-based Psilocybin Therapy for PTSD
Anthony P King
Post Traumatic Stress DisorderDepression - Major Depressive Disorder
Recruiting·Early Phase 1·LSD
Mood Effects of Serotonin Agonists: Depression
University of Chicago
LSDMajor Depressive DisorderDepression
Enrolling by Invitation·N/A·psilocybin
Salivary Oxytocin as a Biomarker of Psychedelic Treatment
University of Geneva, Switzerland
Major Depressive Disorder (MDD)
Completed·N/A·ketamine
Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Massachusetts General Hospital
Major Depressive Disorder
Terminated·N/A·psilocybin
PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder
Usona Institute
Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
Major Depressive DisorderAnhedoniaTreatment Resistant Depression
Completed·Phase 2·ketamine
Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
VA Connecticut Healthcare System
Major Depressive DisorderAlcohol Use Disorder
Completed·Phase 2·psilocybin
Effects of Psilocybin in Major Depressive Disorder
Johns Hopkins University
Major Depressive Disorder
Active, Not Recruiting·Phase 1·psilocybin
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
Eleusis Therapeutics
Healthy VolunteersMajor Depressive DisorderDepression
Completed·Phase 2·psilocybin
Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms
Imperial College London
Depressive Disorder, Major
Unknown·Early Phase 1·ketamine
Ketamine for Mood Disorders With Suicidal Ideation
The Miriam Hospital
Depressive Disorder, MajorSuicidal Ideation
Recruiting·Phase 3·ketamine
Early Effects of Ketamine vs Placebo With Venlafaxine in Severe Depression Patients
Assistance Publique - Hôpitaux de Paris
Major Depressive Episode
Completed·N/A·ketamine
Chart Review of Patients Undergoing Ketamine Infusions
Brain and Cognition Discovery Foundation
Major Depressive DisorderBipolar DisorderObsessive-Compulsive Disorder+1 more
Not Yet Recruiting·Phase 3·ketamine
Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in Adolescents
Federal University of São Paulo
Depressive DisorderSuicidal Ideas
Completed·N/A·ketamine
Brain Network Dynamics of Depression During Esketamine Treatment
University of North Carolina, Chapel Hill
Depressive Disorder, Major
Suspended·Phase 3·ketamine
Ketamine Versus Electroconvulsive Therapy in Depression
University of Ottawa
Depressive Disorder, MajorBipolar Depression
Completed·Early Phase 1·ketamine
A Multimodal Neuroimaging Study of Brain Activation Patterns Under Ketamine
Psychiatric University Hospital, Zurich
Major Depressive Disorder
Completed·Phase 4·ketamine
Research Study for Major Depressive Disorder: Investigation of Glutamate Medications
Baylor College of Medicine
Major Depression
Completed·N/A·ketamine
A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders
Medical University of Gdansk
Treatment Resistant DepressionBipolar DepressionKetamine+1 more
Unknown·N/A·ketamine
Naturalistic Study of Ketamine in the Treatment of Depression
Hospital de Clinicas de Porto Alegre
Major Depressive DisorderBipolar DisorderBipolar Depression+3 more
Not Yet Recruiting·Phase 2·ketamine
A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression
Daniel Lindqvist
Major Depressive Disorder (MDD)
Completed·Phase 2·psilocybin
Microdosing Psychedelics to Improve Mood
Rotem Petranker
Major Depressive Disorder
Recruiting·Phase 2·ketamine
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
National Institute of Mental Health (NIMH)
SuicideDepressive Disorder, Treatment-ResistantKetamine+10 more
Completed·Phase 1·Other
IM and IV SPL026 Drug Product in Healthy Participants
Small Pharma Ltd
Major Depressive Disorder
Unknown·Phase 2·psilocybin
The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder
Maryland Oncology Hematology, PA
Major Depressive Disorder
Enrolling by Invitation·Phase 1·Other
Induction of Dreaming With EEG and Anesthesia in Healthy Adults
Stanford University
Healthy Volunteers
Completed·Phase 2·ketamine
Ketamine as an Alternative Treatment to ECT in Major Depressive Disorder
Pouya Movahed Rad
Depressive Disorder, Major
Completed·Phase 2·ketamine
Ketamine for Depression and Suicide Risk
Mayo Clinic
DepressionSuicide
Completed·N/A·Other
2-Year Study of Vagus Nerve Stimulation for Higher-Grade Treatment-Resistant Depression: Clinical Outcomes and Policy Recommendation
Dr.Yoav Domany
Treatment Resistant Depression (TRD)Depression - Major Depressive DisorderBipolar Depression
Not Yet Recruiting·Phase 2·ketamine
Ketamine Treatment for PTSD and MDD in TBI
Minneapolis Veterans Affairs Medical Center
PTSD, Post Traumatic Stress DisorderMajor Depressive DisorderTraumatic Brain Injury
Recruiting·N/A·ketamine
ACT_for Alcohol Use Disorder and Depression
Centre hospitalier de l'Université de Montréal (CHUM)
Depression - Major Depressive DisorderAlcohol Use Disorder
Not Yet Recruiting·N/A·ketamine
Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression
Chinese PLA General Hospital
DepressionAnxietyS-ketamine+1 more
Recruiting·Phase 2·psilocybin
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Withdrawn·Phase 2·psilocybin
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD
Massachusetts General Hospital
Treatment-Resistant Major Depressive Disorder
Not Yet Recruiting·Phase 3·psilocybin
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
VA Office of Research and Development
Major Depression
Completed·Phase 4·ketamine
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
Northwell Health
Unipolar DepressionBipolar Depression
Completed·Phase 4·ketamine
Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression
Taipei Veterans General Hospital, Taiwan
Treatment-resistant DepressionMajor Depressive Disorder
Completed·Phase 2·psilocybin
The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density
Section for Affective Disorders; Northern Stockholm Psychiatry
Major Depressive DisorderDepression
Completed·Phase 1·ketamine
Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects
AstraZeneca
Depression
Completed·Phase 3·ketamine
54135419SUI3001: A Study to Evaluate the Efficacy and Safety of Intranasal Esketamine in Addition to Comprehensive Standard of Care for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Adult Participants Assessed to be at Imminent Risk for Suicide
Janssen Research & Development, LLC
Depressive Disorder, Major
Recruiting·N/A·ketamine
The OBSERVE Protocol
Yale University
Major Depression Disorder
Unknown·Phase 2·ketamine
An Open Prospective Trial of IV Ketamine in Suicidal Adolescents
Nationwide Children's Hospital
Major Depressive Disorder
Completed·Phase 2·psilocybin
A Study of Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Active, Not Recruiting·Phase 2·ketamine
A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder
Clexio Biosciences Ltd.
Adjunctive Treatment of Major Depressive Disorder (MDD)
Completed·Phase 4·ketamine
Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression
Maimonides Medical Center
Treatment Resistant DepressionMajor Depressive DisorderAnalgesia+10 more
Completed·Phase 4·ketamine
Ketamine Infusion for Adolescent Depression and Anxiety
Yale University
Major Depressive DisorderAnxiety Disorder
Recruiting·N/A·psilocybin
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
OCDMajor Depressive Disorder (MDD)Alcohol Use Disorder (AUD)+8 more
Completed·Phase 1·ketamine
Ketamine as an Adjunctive Therapy for Major Depression
St Patrick's Hospital, Ireland
Major Depressive EpisodeUnipolar DepressionBipolar Depression
Completed·Phase 4·ketamine
Intra-nasal vs. Intra-venous Ketamine Administration
Shalvata Mental Health Center
Major Depressive Disorder
Completed·Phase 2·ketamine
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment Outcome
University of Alabama at Birmingham
Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
Johns Hopkins University
Major Depressive DisorderAlcohol Use Disorder
Unknown·Phase 4·ketamine
An EEG Study of Intravenous Ketamine for Major Depression Disorder
Ehave Inc.
Major Depressive Disorder
Unknown·N/A·ketamine
Using a Low Dose of Ketamine vs. Active Placebo in Treating Severe Depression and Suicide
Taipei Veterans General Hospital, Taiwan
Major Depressive Disorder
Completed·Phase 2·psilocybin
The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation
Sheppard Pratt Health System
Treatment Resistant DepressionSuicidal Ideation
Recruiting·N/A·Other
Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
Unity Health Toronto
Major Depressive Disorder (MDD)Major Depressive EpisodeTreatment-Resistant Major Depressive Disorder
Not Yet Recruiting·Phase 1·ketamine
Ketamine Biomarker Validation
Soterix Medical
Treatment Resistant Depression (TRD)
Recruiting·Phase 1·ketamine
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
National Institute of Mental Health (NIMH)
Healthy VolunteerMajor Depressive DisorderDepression
Active, Not Recruiting·Early Phase 1·ketamine
Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:
Mayo Clinic
Major Depressive DisorderTreatment Resistant DepressionBipolar Depression
Completed·Phase 3·ketamine
Ketamine As an Adjunctive Therapy for Major Depression (2)
University of Dublin, Trinity College
Major Depressive EpisodeUnipolar DepressionBipolar Depression
Recruiting·Phase 2·ketamine
Ketamine-Assisted Psychotherapy (KAP) Compared to Ketamine Alone for the Treatment of Depression
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Recruiting·Phase 2·ketamine
Imaging Depression in Parkinson's Disease
Yale University
Parkinson's DiseaseMajor Depressive Disorder
Completed·Phase 1·ketamine
A Multiple Ascending Dose Study of BCI-838 in Healthy Volunteers
BrainCells Inc.
Healthy
Completed·N/A·ketamine
Role Of Ketamine in Treatment-Resistant Major Depressive Disorder And Its Effect on Suicidality
Assiut University
Treatment Resistant Depression
More trials available. Refine your search to see specific results.
How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.