24 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 100 of 510 trials
Withdrawn·Phase 2·ketamine
Repeated Intranasal Esketamine Plus Almond Therapy in Participants With Treatment Resistant Depressive Disorder - 3 Month Extension Study
Zylorion Health
Treatment Resistant Major Depressive Disorder
Withdrawn·Phase 3·ketamine
Endogenous Opioid Modulation by Ketamine
University of Utah
Major Depressive Disorder
Completed·N/A·ketamine
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
Yale University
Depression and Suicide
Completed·Phase 2·ketamine
A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide
Janssen Research & Development, LLC
Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)
Sheppard Pratt Health System
Treatment Resistant Depression
Completed·Phase 1·ketamine
Ketamine + Mindfulness for Depression
Rebecca Price
Depression, Unipolar
Unknown·Phase 2·psilocybin
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSD
Apex Labs Ltd.
Post-traumatic Stress DisorderDepression
Recruiting·Phase 1·ketamine
Imaging Neural Correlates of Ketamine Using PET/MR
Medical University of Vienna
Major Depressive Disorder
Completed·Phase 4·ketamine
A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)
Massachusetts General Hospital
Depression
Recruiting·Phase 4·ketamine
Positioning of Esketamine Treatment in the Real-world Management of Depression
Royal North Shore Hospital
Major Depressive Disorder
Completed·Phase 2·ketamine
Evaluation of the Initial Prescription of Ketamine and Milnacipran in Depression in Patients With a Progressive Disease
University Hospital, Lille
Depression
Completed·Phase 1·psilocybin
Psilocybin-assisted CBT for Depression
University of California, Los Angeles
Major Depressive Disorder
Unknown·N/A·ketamine
Ketamine Infusions for Major Depression Disorder
Sheba Medical Center
Depressive Disorder, Major
Recruiting·Phase 2·psilocybin
Does Psilocybin Require Psychedelic Effects to Treat Depression?
Centre for Addiction and Mental Health
Treatment-resistant Depression
Completed·N/A·ketamine
Ketamine Anesthesia in Electroconvulsive Therapy
Mayo Clinic
Depression
Unknown·Phase 1·ketamine
Study of Ketamine as an Antidepressant in Major Depressive Disorder
Shi Jinyun
Major Depressive Disorder
Completed·Phase 4·ketamine
Ketamine for Older Adults Pilot
Washington University School of Medicine
Treatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more
Completed·Phase 1·ketamine
Biomarkers of Fast Acting Therapies in Major Depression
University of California, Los Angeles
Major Depressive Disorder
Recruiting·N/A·ketamine
Veteran's Perceptions of Ketamine-Assisted Psychotherapy for Depression and End-of-Life
Albany Research Institute, Inc.
Depression
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Completed·Phase 1·ketamine
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
Yale University
Depressive Disorder, MajorPost Traumatic Stress DisorderBipolar Disorder
Withdrawn·Phase 1·ketamine
A Study to Assess Feasibility of Using Clinician-directed and Digital Application Supported Cognitive Behavior Therapy (CBT) in Conjunction With Esketamine in Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Depression
Completed·Phase 1·ketamine
Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
VA Office of Research and Development
Major Depressive DisorderAlcohol Use Disorder
Unknown·Phase 4·ketamine
D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression
Sheba Medical Center
Treatment Resistant Depression
Terminated·Phase 2·DMT
Phase 2 Clinical Trial of GH001 in Postpartum Depression
GH Research Ireland Limited
Postpartum DepressionPostnatal Depression
Recruiting·Phase 2·ketamine
ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response
ACADIA Pharmaceuticals Inc.
Major Depressive Disorder (MDD)Depressive Disorder, Treatment-Resistant
Completed·Phase 2·psilocybin
Psychopharmacology of Psilocybin in Cancer Patients
Johns Hopkins University
Depressive SymptomsAnxietyCancer
Withdrawn·Phase 2·ketamine
Trial of Ketamine and Lithium Therapy in Bipolar Depression
Yale University
Bipolar Depression
Recruiting·Phase 4·ketamine
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression
Massachusetts General Hospital
Major Depressive Disorder
Completed·Phase 1·ketamine
A Study of HR071603(Ketamine Nasal Spray) in Healthy Subjects
Jiangsu HengRui Medicine Co., Ltd.
Depression
Completed·Phase 3·ketamine
Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six Weeks
University Hospital, Grenoble
Major Depressive Disorder
Completed·Phase 3·ketamine
An Expanded Access Protocol for Esketamine Treatment in Participants With Treatment Resistant Depression (TRD) Who do Not Have Other Treatment Alternatives
Janssen-Cilag, S.A.
Depression
Completed·Phase 3·ketamine
Ketamine for Postoperative Avoidance of Depressive Symptoms: The K-PASS Feasibility Trial
Washington University School of Medicine
Postoperative Depression
Completed·N/A·ketamine
Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression
Douglas Mental Health University Institute
Depressive Disorder, Treatment-ResistantDepressive Disorder, MajorUnipolar Depression+1 more
Unknown·Phase 3·ketamine
The Effect of Ketamine on Mechanises Underlying Suicidal Ideation and Drug-resistant Major Depression
Tel-Aviv Sourasky Medical Center
Suicidal IdeationMajor Depressive DisorderHealthy Participants
Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Therapy for Intergenerational Trauma
Rachel Yehuda
Psychological StressDepressionAnxiety
Completed·N/A·Other
Neurocognitive Features of Patients With Treatment-Resistant Depression
Massachusetts General Hospital
Treatment Resistant Depression
Recruiting·Phase 2·ketamine
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Yale University
Depressive DisorderMajor Depressive DisorderBipolar Disorder+2 more
Completed·Phase 1·ketamine
Ketamine Trial for the Treatment of Depression
The University of New South Wales
Unipolar Depression
Completed·N/A·ketamine
Neural Correlates of Ketamine's Anti-suicidal Effects in Bipolar Depression
Centre for Addiction and Mental Health
Bipolar Disorder (BD)Suicidality
Unknown·Phase 4·ketamine
Hyperventilation Combined With Etomidate or Ketamine Anesthesia in ECT Treatment of Major Depression
University of Manitoba
Depression
Completed·Phase 1·ketamine
KET-RO Plus RO DBT for Treatment Resistant Depression
Washington University School of Medicine
Treatment Resistant Depression
Completed·N/A·psilocybin
Low-Income Group Psilocybin Assisted Therapy for Depression
Matthew Hicks
Depression
Enrolling by Invitation·Phase 4·ketamine
Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan
Brigham and Women's Hospital
Acute Suicidal Depression (ASD)
Withdrawn·Phase 4·ketamine
Ketamine Frequency Treatment for Major Depressive Disorder
Essentia Health
Treatment Resistant Depression
Completed·N/A·Other
Characterization of the Prosocial and Prosexual Effects of GHB
University of Zurich
Depressive Disorder, MajorBipolar DisorderAutistic Disorder
Completed·N/A·ketamine
Chart Review of Patients Undergoing Ketamine Treatments for Depression
Sunnybrook Health Sciences Centre
Depression - Major Depressive Disorder
Recruiting·Phase 1·ketamine
Mechanism of Action Underlying Ketamine's Antidepressant Effects: The AMPA Throughput Theory in Patients With Treatment-Resistant Major Depression
National Institute of Mental Health (NIMH)
DepressionMajor Depressive DisorderMajor Depression
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
Yale University
Major Depressive Disorder
Recruiting·Phase 3·ketamine
Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting
Theresa Jacob, PhD, MPH
Severe DepressionModerate DepressionKetamine+16 more
Unknown·N/A·ketamine
Dose Low Dose Ketamine in Casesarian
Inonu University
Postoperative PainPostpartum Depression
Completed·N/A·ketamine
Esketamine on Postpartum Depression in Cesarean Section Women
Ailin Luo
EsketaminePostpartum Depression
Withdrawn·Phase 3·ketamine
ECT vs. Esketamine
Medical University Innsbruck
Treatment Resistant DepressionMajor Depressive Disorder
Recruiting·Phase 2·psilocybin
Investigation to Understand and Optimize Psilocybin
Charles Raison
Depression
Completed·Phase 4·ketamine
Effectiveness of Ketamine Treatment for Three Consecutive Days in Depression
Mahidol University
Depression
Completed·Phase 4·ketamine
Ketamine in the Treatment of Suicidal Depression
New York State Psychiatric Institute
Major Depressive DisorderSuicidal Ideation
Completed·N/A·Other
Dance Movement Therapy in the Treatment of Depressed Patients: A Randomised Controlled Trial
University of Jyvaskyla
Depression
Completed·Phase 1·ketamine
Ketamine for Depression and Alcohol Dependence
Yale University
DepressionAlcohol Dependence
Withdrawn·Phase 4·ketamine
Preoperative Ketamine and Perioperative Depression
Northwestern University
Depressive Disorder
Unknown·N/A·ketamine
In Vitro Modeling of Drug-resistant Psychiatric Disorders Using Induced Pluripotent Cells
University of Milano Bicocca
Depressive Disorder, Treatment-Resistant
Recruiting·Phase 3·psilocybin
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
Cybin IRL Limited
Major Depressive Disorder
Recruiting·N/A·ketamine
Esketamine for Prevention of Depression After Cytoreductive Surgery in Ovarian Cancer
Zhejiang Cancer Hospital
Ovarian CancerCytoreductive SurgeryDepressive Symptom
Completed·Phase 1·psilocybin
PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout
University of Utah
DepressionBurnout, Professional
Completed·Phase 2·ketamine
Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects
Yale University
Depression
Recruiting·Phase 4·ketamine
ECT with Ketamine Anesthesia Vs High Intensity Ketamine with ECT Rescue for Treatment-Resistant Depression
University of Saskatchewan
Treatment Resistant DepressionKetamine
Completed·Phase 3·ketamine
A Study to Evaluate the Efficacy, Safety, and Tolerability of Flexible Doses of Intranasal Esketamine Plus an Oral Antidepressant in Adult Participants With Treatment-resistant Depression
Janssen Research & Development, LLC
Treatment-resistant Depression
Withdrawn·Phase 1·ketamine
Intravenous Ketamine Effects on Functional Neuroanatomy
Neurological Associates of West Los Angeles
Depression
Completed·Phase 2·ketamine
Efficacy of Repeated Ketamine Infusions for Treatment-resistant Depression
VA Office of Research and Development
Treatment-resistant Depression
APPROVED_FOR_MARKETING·N/A·ketamine
Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)
Janssen Research & Development, LLC
Depressive Disorder, Treatment-Resistant
Active, Not Recruiting·N/A·ketamine
Safety and Efficacy of Ketamine Intravenous Infusions in the Treatment of Fibromyalgia
Wilderman Medical Clinic
Fibromyalgia
Recruiting·Phase 3·psilocybin
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
Major Depressive Disorder (MDD)Depression in AdultsDepression - Major Depressive Disorder+3 more
Completed·Phase 4·ketamine
Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency Department
MercyOne Des Moines Medical Center
DepressionDepression SevereDepression Acute+2 more
Completed·Early Phase 1·ketamine
EEG Characteristics in ECT
University of New Mexico
Electroconvulsive TherapyDirect Current ElectroencephalogramKetamine+1 more
Withdrawn·Phase 2·ketamine
Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency Department
Maria Pacella
Acute PainDepression
Terminated·Phase 2·ketamine
A Study to Investigate Evoked Potentials as Markers of Ketamine-induced Cortical Plasticity in Patients With Major Depressive Disorder
Janssen Research & Development, LLC
Major Depressive Disorder
Completed·Phase 2·ketamine
A Study to Evaluate the Efficacy, Safety and Tolerability of Fixed Doses of Intranasal Esketamine in Japanese Participants With Treatment Resistant Depression
Janssen Pharmaceutical K.K.
Depression
Terminated·Phase 2·ketamine
Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer
Mayo Clinic
CancerDepressionAnxiety
Active, Not Recruiting·Phase 4·ketamine
Effect of Low-dose Esketamine on Maternal Depression at 3 Years After Childbirth
Peking University First Hospital
Prenatal DepressionKetaminePostpartum Depression
Terminated·N/A·ketamine
Use of Ketamine to Enhance Electroconvulsive Therapy (ECT) in Depression
James Murrough
Major DepressionBipolar Depression
Completed·Phase 2·ketamine
A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD
Perception Neuroscience
Treatment Resistant Depression
Completed·N/A·ketamine
Pharmacogenetics Associated With IV Ketamine
Brain and Cognition Discovery Foundation
Treatment Resistant Depression
Unknown·Phase 4·ketamine
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
Chinese PLA General Hospital
Postoperative PainAdultsAnesthesia
Not Yet Recruiting·Phase 2·psilocybin
Mindfulness-based Psilocybin Therapy for PTSD
Anthony P King
Post Traumatic Stress DisorderDepression - Major Depressive Disorder
Recruiting·Early Phase 1·LSD
Mood Effects of Serotonin Agonists: Depression
University of Chicago
LSDMajor Depressive DisorderDepression
Enrolling by Invitation·N/A·psilocybin
Salivary Oxytocin as a Biomarker of Psychedelic Treatment
University of Geneva, Switzerland
Major Depressive Disorder (MDD)
Completed·N/A·ketamine
Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder
Massachusetts General Hospital
Major Depressive Disorder
Terminated·N/A·psilocybin
PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder
Usona Institute
Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
Major Depressive DisorderAnhedoniaTreatment Resistant Depression
Completed·Phase 2·ketamine
Naltrexone Plus Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder
VA Connecticut Healthcare System
Major Depressive DisorderAlcohol Use Disorder
Completed·N/A·ketamine
Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State
Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
Depressive Disorder
Completed·Phase 2·psilocybin
Effects of Psilocybin in Major Depressive Disorder
Johns Hopkins University
Major Depressive Disorder
Completed·Phase 2·psilocybin
The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression
COMPASS Pathways
Treatment Resistant Depression
Active, Not Recruiting·Phase 1·psilocybin
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
Eleusis Therapeutics
Healthy VolunteersMajor Depressive DisorderDepression
Withdrawn·Early Phase 1·ketamine
Ketamine for Preventing Depression in Patients Undergoing Treatment for Pancreatic or Head and Neck Cancers
Cedars-Sinai Medical Center
Head and Neck CancerPancreatic CancerDepression
Completed·Phase 2·psilocybin
Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms
Imperial College London
Depressive Disorder, Major
Unknown·Early Phase 1·ketamine
Ketamine for Mood Disorders With Suicidal Ideation
The Miriam Hospital
Depressive Disorder, MajorSuicidal Ideation
Unknown·Phase 4·ketamine
Clinical Trial of the Use of Ketamine in Treatment Resistant Depression
National Institute of Neurology and Neurosurgery, Mexico
Depressive Disorder, Treatment-Resistant
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
M.D. Anderson Cancer Center
Depression, AnxietyPsilocybin-Assisted PsychotherapyAdvanced Cancer
Unknown·Phase 3·ketamine
Ketamine in Bariatric Surgery
University of Padova
Morbid Obesity
Recruiting·Phase 3·ketamine
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
Yale University
Depression
More trials available. Refine your search to see specific results.
How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.