24 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 100 of 115 trials
Withdrawn·Phase 4·ketamine
A Randomized, Double-Blind Study of Placebo vs. Ketamine For Use During Dressing Changes in Critically Ill Burn Patients
University of Colorado, Denver
Thermal HyperalgesiaAnxietyPain
Recruiting·Phase 3·LSD
A Phase 3 Trial of MM120 for Generalized Anxiety Disorder (Voyage)
Definium Therapeutics US, Inc.
Generalized Anxiety Disorder
Completed·Phase 2·LSD
Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related Anxiety
Multidisciplinary Association for Psychedelic Studies
Anxiety
Completed·Phase 2·psilocybin
Psychopharmacology of Psilocybin in Cancer Patients
Johns Hopkins University
Depressive SymptomsAnxietyCancer
Completed·Phase 2·MDMA
Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults
Lykos Therapeutics
Social Anxiety in Autistic Adults
Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Therapy for Intergenerational Trauma
Rachel Yehuda
Psychological StressDepressionAnxiety
Terminated·Phase 2·ketamine
Randomized Controlled Trial of Intranasal Ketamine vs. Intranasal Midazolam in Individuals With OCD
New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Completed·Phase 2·MDMA
Social Anxiety MDMA-Assisted Therapy Investigation
Jason B Luoma
Social Anxiety Disorder
Recruiting·Phase 3·ketamine
Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting
Theresa Jacob, PhD, MPH
Severe DepressionModerate DepressionKetamine+16 more
Completed·Early Phase 1·ketamine
Ketamine Infusion for Social Anxiety Disorder
Yale University
Social Anxiety Disorder
Recruiting·Phase 4·ketamine
Sedation Versus Protective Stabilization for Pediatric Dental Treatment
Universidade Federal de Goias
Child BehaviorDental Caries in Children
Terminated·Phase 2·ketamine
Oral Ketamine in the Treatment of Depression and Anxiety in Patients With Cancer
Mayo Clinic
CancerDepressionAnxiety
Unknown·Phase 4·ketamine
Safety and Efficacy Evaluation of S (+) - Ketamine in Adults
Chinese PLA General Hospital
Postoperative PainAdultsAnesthesia
Completed·N/A·ketamine
Impact of Pre-Sedation Virtual Reality Game on Post-Discharge Negative Behaviors in the Pediatric Emergency Department
Medical College of Wisconsin
Behavior, ChildAnxiety
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
M.D. Anderson Cancer Center
Depression, AnxietyPsilocybin-Assisted PsychotherapyAdvanced Cancer
Completed·Phase 2·ketamine
Sevoflurane Associated With Oral Midazolam and Ketamine for Dental Sedation
Universidade Federal de Goias
Dental Anxiety
Completed·N/A·ketamine
Chart Review of Patients Undergoing Ketamine Infusions
Brain and Cognition Discovery Foundation
Major Depressive DisorderBipolar DisorderObsessive-Compulsive Disorder+1 more
Completed·Phase 2·ketamine
Ketamine Infusion for Obsessive-Compulsive Disorder
Yale University
Obsessive-compulsive Disorder
Completed·Phase 2·MDMA
MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening Illness
Lykos Therapeutics
Anxiety
Terminated·Phase 2·MDMA
MDMA-assisted Therapy in People With Anxiety Related to Advanced Stage Cancer
Brigham and Women's Hospital
Anxiety DisorderCancer
Not Yet Recruiting·Phase 1·psilocybin
Psilocybin for Treatment of OCD-2
Francisco A Moreno
Obsessive - Compulsive Disorder
Completed·Phase 1·DMT
Efficacy of Sublingual 5-MeO-DMT for Reducing Anxiety and Depression in MCI
Biomind Labs Inc.
Mild Cognitive ImpairmentAnxiety StateDepression Anxiety Disorder
Recruiting·Phase 2·ketamine
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
Stanford University
Obsessive-Compulsive Disorder
Unknown·N/A·ketamine
The Effect of Esketamine on Patients Undergoing Tumor Surgery
Second Affiliated Hospital, School of Medicine, Zhejiang University
Tumor Surgery
Unknown·Phase 4·ketamine
Clinical Study of Oral Midazolam Combined With Esketamine Administered Intranasally for Pediatric Preoperative Sedation
Second Affiliated Hospital of Wenzhou Medical University
Anxiety
Not Yet Recruiting·N/A·ketamine
Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression
Chinese PLA General Hospital
DepressionAnxietyS-ketamine+1 more
Recruiting·N/A·ketamine
Ketamine Treatment Plans for Chronic Conditions
RIVER Foundation
Chronic PainDepressive DisorderAnxiety Disorders+1 more
Completed·N/A·ketamine
Ketamine Infusion Therapy for the Treatment of PTSD in Paramedics
Klarisana Physician Services PLLC
Stress Disorders, Post-TraumaticAnxiety Disorders
Completed·Phase 2·ketamine
Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Dennis Charney
Stress Disorders, Post-TraumaticPTSDDepression+1 more
Completed·N/A·Other
Correlates of Anxiety Associated With a Life-threatening Illness
Lykos Therapeutics
Anxiety
Completed·Phase 4·ketamine
Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt Insertion
Benha University
Depression, Anxiety
Completed·Phase 4·ketamine
Perioperative Electroacupuncture on Postoperative Analgesia in Prostatectomy
G.Gennimatas General Hospital
Pain, Postoperative
Recruiting·Phase 1·psilocybin
Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD
Centre for Addiction and Mental Health
Obsessive-Compulsive Disorder
Completed·Phase 4·ketamine
Ketamine Infusion for Adolescent Depression and Anxiety
Yale University
Major Depressive DisorderAnxiety Disorder
Recruiting·N/A·psilocybin
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
OCDMajor Depressive Disorder (MDD)Alcohol Use Disorder (AUD)+8 more
Completed·Phase 1·DMT
Safety, Tolerability, and Efficacy of Sublingual Microdoses of 5-MeO-DMT for Depression and Anxiety
Biomind Labs Inc.
Healthy Volunteers
Recruiting·Phase 1·ketamine
Pilot Study of RR-HNK in OCD
Carolyn Rodriguez
Obsessive-Compulsive Disorder
Not Yet Recruiting·N/A·ketamine
Comparative Assessment of Oral Premedication Regimens in Pediatric Ambulatory Surgery
Diskapi Yildirim Beyazit Education and Research Hospital
Pediatric AnesthesiaPremedication
Unknown·N/A·DMT
Unified Cognitive-Behavioral Therapy (CBT) vs. Combined CBT and Dance/Movement Therapy (DMT) for Anxiety Disorders
Shalvata Mental Health Center
Anxiety Disorders
Terminated·Phase 2·ketamine
A Trial of Intranasal Ketamine for the Treatment of Obsessive-Compulsive Disorder
Mclean Hospital
Obsessive-Compulsive Disorder
Completed·Phase 2·LSD
LSD Treatment in Persons Suffering From Anxiety Symptoms in Severe Somatic Diseases or in Psychiatric Anxiety Disorders
University Hospital, Basel, Switzerland
PatientsAnxiety Disorders
Completed·Phase 1·ketamine
Ketamine Treatment for Pediatric-Refractory Obsessive-Compulsive Disorder (OCD)
New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Not Yet Recruiting·Phase 2·psilocybin
Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies
University of Washington
AnxietyDepressionHematopoietic and Lymphatic System Neoplasm+1 more
Not Yet Recruiting·Phase 3·ketamine
Morphine or Ketamine for Analgesia
Columbia University
Abdominal PainIsolated Extremity FracturePain+1 more
Completed·Early Phase 1·ketamine
S-ketamin Premedication in Pediatric EENT Surgery
Eye & ENT Hospital of Fudan University
EmotionsSeparation AnxietyPain, Procedural
Completed·Phase 1·psilocybin
Effects of Psilocybin in Advanced-Stage Cancer Patients With Anxiety
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Anxiety
Active, Not Recruiting·N/A·psilocybin
Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment
University Hospital, Geneva
Major Depressive Disorder (MDD)Anxiety DisordersSubstance Use Disorder (SUD)+1 more
Enrolling by Invitation·N/A·ketamine
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)
Medical University of Gdansk
Major Depressive DisorderPost Traumatic Stress DisorderObsessive-Compulsive Disorder+3 more
Completed·Phase 2·ketamine
Extending Ketamine's Effects in OCD With Exposure and Response Prevention (EX/RP)
New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-assisted Therapy for Alcohol Use Disorder
University of Sydney
Alcohol Use DisorderAlcohol DependenceDepression+1 more
Enrolling by Invitation·N/A·ketamine
Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric Interventions
Psyrin Inc.
Obsessive Compulsive Disorder (OCD)Bipolar DisordersMajor Depressive Disorder+2 more
Completed·N/A·ketamine
Effect of Esketamine on Anxiety State in Patients Undergoing Abdominal Tumor Surgery
Zhejiang Cancer Hospital
Anxiety StateEsketamine
Completed·Phase 2·Other
Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder
New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Completed·N/A·LSD
Salivary Oxytocin as a Biomarker in Psychedelic Assisted Psychotherapy
Tatiana Aboulafia Brakha
Depression, Anxiety
Recruiting·N/A·ketamine
Esketamine Combined With Remimazolam on Postoperative Sleep Disturbance and Anxiety in Patients
Tianjin Medical University General Hospital
Sleep Disturbance
Completed·N/A·ketamine
Tolerance and Potential Synergistic Effect of the Combination of Intranasal Esketamine and Non-selective MAOI
University Hospital, Strasbourg, France
Depression Anxiety Disorder
Not Yet Recruiting·Early Phase 1·ketamine
Effects of Intranasal Ketamine on Depression and Anxiety in Palliative Care Cancer Patients
University of Zurich
Depressive Symptoms Mild to Moderate in SeverityAnxietyQuality of Life (QOL)+2 more
Withdrawn·Early Phase 1·ketamine
Ketamine-Assisted PsychoTherapy ViAbility in Treating Cancer-related Emotional Distress
Northwell Health
Cancer-related Problem/ConditionDepressive SymptomsAnxiety Disorders
Recruiting·N/A·ketamine
University of Iowa Interventional Psychiatry Service Patient Registry
Mark Niciu
Treatment Resistant DepressionMajor Depressive EpisodeMajor Depression+4 more
Recruiting·Phase 2·LSD
Lysergic Acid Diethylamide (LSD) in Palliative Care
University Hospital, Basel, Switzerland
Palliative CarePainAnxiety+7 more
Withdrawn·Early Phase 1·psilocybin
Mood and Cognitive Effects of Psilocybin in Healthy Participants
Optimi Health Corporation
Mood DisturbanceMood ChangeSleep Disturbance+7 more
Completed·Phase 1·ketamine
Ketamine Infusions for PTSD and Treatment-Resistant Depression
Minneapolis Veterans Affairs Medical Center
Depressive Disorder, Treatment-ResistantStress Disorders, Post-Traumatic
Recruiting·Phase 4·ketamine
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
University of Oklahoma
Laceration of SkinAnxietyDischarge Time
Recruiting·N/A·ketamine
Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments
Neuronetics
DepressionOCDAnxiety Depression
Active, Not Recruiting·Phase 2·ketamine
Understanding How Ketamine Brings About Rapid Improvement in OCD
Stanford University
Obsessive-Compulsive Disorder
Completed·N/A·Other
Pediatric Laser Acupuncture and Renal Biopsy
University of California, San Francisco
PainAnxiety
Unknown·Phase 3·ketamine
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
University of Glasgow
Cancer
Recruiting·Phase 2·psilocybin
Safety, Tolerability, and Preliminary Efficacy of Psilocybin Oral Solution in Adults With Generalized Anxiety Disorder
Queen's University
Generalized Anxiety Disorder (GAD)
Active, Not Recruiting·Phase 2·DMT
A Study of a N, N-dimethyltryptamine (DMT) Analog (CYB004) in Participants With Generalized Anxiety Disorder (GAD)
Cybin IRL Limited
Generalized Anxiety Disorder
Unknown·Phase 2·ketamine
Ketamine and Neuropathic Pain
University Hospital, Clermont-Ferrand
Neuropathic Pain
Recruiting·Phase 1·psilocybin
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
TransdiagnosticDepression - Major Depressive DisorderAnxiety+5 more
Active, Not Recruiting·Phase 2·psilocybin
TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors
M.D. Anderson Cancer Center
DepressionAnxietyCancer
Completed·N/A·ketamine
Esketamine vs Remimazolam for Postoperative Sleep Disturbance and Anxiety
Tianjin Medical University General Hospital
Sleep Disturbance
Terminated·Early Phase 1·ketamine
Ketamine-assisted Psychotherapy (KAP) for Patients With Existential Distress Associated With Non-operable GI Cancers
University of Utah
Gastrointestinal CancerDepressionAnxiety
Completed·Phase 2·LSD
A Dose-Finding Study of MM-120 (LSD D-Tartrate) for the Treatment of Anxiety Symptoms
Definium Therapeutics US, Inc.
Anxiety Generalized
Withdrawn·Phase 2·psilocybin
Assessing the Efficacy of Micro-dosed Psilocybin on Reducing Anxiety & Depression Levels in Adults
Wake Network, Inc.
Anxiety and Depression
Completed·Early Phase 1·psilocybin
Psilocybin Cancer Anxiety Study
NYU Langone Health
Cancer
Completed·Phase 3·ketamine
The Effect of Preprocedural Subanesthetic Ketamine on Pain and Anxiety
Ankara Ataturk Sanatorium Training and Research Hospital
Epidural CatheterizationThoracicProcedural Pain
Recruiting·N/A·ketamine
Esketamine Nasal Spray in Real-World Settings in Treatment-Resistant Depression
Riccardo Guglielmo
Depression and Quality of LifeTreatment Resistant Depression (TRD)Anhedonia+5 more
Recruiting·Phase 2·MDMA
MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)
Carolyn Rodriguez
Obsessive-Compulsive Disorder
Recruiting·Early Phase 1·psilocybin
Effects of Psilocybin in Obsessive Compulsive Disorder
Johns Hopkins University
Obsessive-Compulsive Disorder
Recruiting·N/A·ketamine
RIVER At Home Ketamine Protocols
RIVER Foundation
Chronic ConditionChronic PainChronic Disease+3 more
Completed·N/A·ketamine
Effects Of Different Anesthesia Applications On Mood, Depression, And Anxiety Levels In Burn Patients
T.C. Sağlık Bakanlığı Ankara Bilkent Şehir Hastanesi
Burn Unspecified DegreeDeep Sedation
Completed·Phase 2·psilocybin
Psilocybin Therapy for Depression and Anxiety in Parkinson's Disease
Joshua Woolley, MD, PhD
Parkinson DiseaseDepressionAnxiety
Recruiting·Phase 4·ketamine
Neural Circuit Effects of Ketamine in Depression
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Not Yet Recruiting·N/A·ketamine
Effect of Esketamine on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery
Chinese PLA General Hospital
DepressionAnxietyS-ketamine+1 more
Completed·Phase 1·psilocybin
A Second Psilocybin Group Therapy for the Treatment of Cancer-Related Anxiety in Partial Responders With Metastatic Cancer
University of Washington
Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid Neoplasm
Completed·Phase 1·psilocybin
Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
Yale University
Obsessive-Compulsive Disorder
Not Yet Recruiting·N/A·ketamine
Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression
Chinese PLA General Hospital
DepressionAnxietyS-ketamine+1 more
Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Psychotherapy in Cancer Patients With Adjustment Disorder
Psyence Australia Pty Ltd
Adjustment DisorderAdjustment Disorder With Anxious MoodCancer+8 more
Completed·Phase 2·ketamine
Pilot Study of Ketamine in Adults With Obsessive-Compulsive Disorder (OCD)
New York State Psychiatric Institute
Obsessive-Compulsive Disorder
Recruiting·Early Phase 1·ketamine
Feasibility Study of Oral Ketamine Versus Placebo for the Treatment of Anxiety in Patients With Pancreatic Cancer
Cedars-Sinai Medical Center
AnxietyPancreatic Cancer
Not Yet Recruiting·Phase 1·psilocybin
Psilocybin Whole Mushroom for the Treatment of Obsessive-compulsive Disorder.
Francisco A Moreno
Obsessive-Compulsive Disorder
Completed·N/A·ketamine
Effect of Esketamine on Perioperative Negative Mood in Patients Undergoing Cardiac Valve Surgery
Chinese PLA General Hospital
Depression, AnxietyCardiac SurgeryS-ketamine
Completed·Phase 1·psilocybin
PsilOCD: A Pharmacological-Challenge Feasibility Study
Imperial College London
Obsessive-Compulsive Disorder
Completed·Phase 4·ketamine
A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health
Field Trip Health
DepressionAnxietyPost Traumatic Stress Disorder
Recruiting·Phase 1·psilocybin
PSilocybin for psYCHological and Existential Distress in PALliative Care (PSYCHED-PAL)
Ottawa Hospital Research Institute
Depression, AnxietyDistress, Emotional
Completed·Phase 4·ketamine
Ketamine for Depression: An MRI Study
Massachusetts General Hospital
DepressionAnxious DepressionMajor Depressive Disorder
Completed·Phase 1·ketamine
Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
University of Minnesota
Post-Traumatic Stress DisordersMajor Depressive Disorder
Not Yet Recruiting·Phase 1·ketamine
Children of Age 2-6years Undergoing Elective Surgery Will be Divided Into Two Groups Randomly. This Study Aims to Evaluate if Intranasal Dexmedetomidine is Better Than Intranasal Ketamine in Producing Sedation and Reducing Parent Separation Anxiety Before Surgery.
Liaquat National Hospital & Medical College
SedationPreoperative Anxiety Experienced by the Pediatric PatientAnxiolytic Effect+1 more
More trials available. Refine your search to see specific results.
How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.