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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 241288 of 1695 trials
Completed·N/A·ketamine

Prospective Multicentre Study of the Use of Ketamine in the Treatment of Refractory Chronic Pain in the French CLCC

Centre Leon Berard

CancerChronic PainNeuropathic Pain+1 more
Completed·N/A·ketamine

Pharmacogenetics Associated With IV Ketamine

Brain and Cognition Discovery Foundation

Treatment Resistant Depression
Completed·N/A·ketamine

Ketamine for Pain Control After Severe Traumatic Injury

Medical College of Wisconsin

Hospital Inpatient Trauma InjuryPain Management
Completed·Early Phase 1·ketamine

Inpatient Single Dose Interventions for Alcohol Use Disorder

Denver Health and Hospital Authority

Alcohol Use Disorder, Severe
Completed·Phase 1·ketamine

Phase 1 Evaluation of (2R,6R)-Hydroxynorketamine

National Institute of Mental Health (NIMH)

Major Depressive Disorder
Completed·N/A·ketamine

Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression

Douglas Mental Health University Institute

Depressive Disorder, Treatment-ResistantDepressive Disorder, MajorUnipolar Depression+1 more
Completed·N/A·ketamine

Analgesic Efficacy of Orally Administered VTS-K for Pain Management

Antonios Likourezos

Pain, Acute
Completed·Phase 2·Other

Cardiac Index and General Anesthesia Without Opioid.

Centre Hospitalier de Montauban

Hip ArthropathyHip Disease
Completed·Phase 1·MDMA

Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·psilocybin

The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density

Section for Affective Disorders; Northern Stockholm Psychiatry

Major Depressive DisorderDepression
Completed·Phase 2·ketamine

A Study of SLS-002 (Intranasal Racemic Ketamine) in Adults With Major Depressive Disorder at Imminent Risk of Suicide

Seelos Therapeutics, Inc.

Depressive Disorder, MajorSuicidal
Completed·Phase 2·ketamine

Ketamine for the Treatment of Opioid Use Disorder and Depression

Medical University of South Carolina

DepressionOpioid-use DisorderOpioid Abuse
Completed·Early Phase 1·DMT

Neurodynamics of Prosocial Emotional Processing Following Serotonergic Stimulation With N,N-Dimethyltryptamine (DMT) and Harmine in Healthy Subjects

Psychiatric University Hospital, Zurich

EmotionsMoodCognitive Function 1, Social+1 more
Completed·Phase 1·ketamine

A Study in Healthy Men to Test Whether BI 409306, BI 425809 or Lamotrigine Can Reverse the Memory Problems Caused by Ketamine

Boehringer Ingelheim

Healthy
Completed·Phase 1·ketamine

Relative Bioavailability Study of MELT-100, IV Midazolam, and IV Ketamine

Melt Pharmaceuticals

Procedural Sedation
Completed·N/A·Other

Characteristics, Adherence, and Persistence Among Multiple Sclerosis Patients Treated With Disease-Modifying Therapies

Novartis

Multiple Sclerosis
Completed·Phase 3·ketamine

The Ketamine for Acute Postoperative Analgesia (KAPA) Trial

University Health Network, Toronto

Postoperative Pain
Completed·Phase 3·ketamine

Ketamine to Prevent PPD After Cesarean

Washington University School of Medicine

Postpartum Depression
Completed·N/A·Other

Pro-inflammatory Role of Blood Platelets in Critically Ill Patients With Septic Shock.

University Hospital, Bordeaux

Septic Shock
Completed·Phase 4·ketamine

A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 2·ibogaine

Preliminary Efficacy and Safety of Ibogaine in the Treatment of Methadone Detoxification

International Center for Ethnobotanical Education, Research, and Service

Drug DependenceDrug Use DisordersOpioid Dependence
Completed·Phase 4·ketamine

Ketamine for Older Adults Pilot

Washington University School of Medicine

Treatment Resistant DepressionRefractory DepressionTherapy-Resistant Depression+2 more
Completed·Phase 1·LSD

Effect of Ketanserin After LSD Administration

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 4·ketamine

Ketamine Treatment Effects on Synaptic Plasticity in Depression

New York State Psychiatric Institute

Major Depressive Disorder
Completed·N/A·Other

Duration of Anaesthesia Induction in Paediatric Patients: Prospective Observational Trial

Brno University Hospital

Anaesthesia Induction
Completed·Phase 3·LSD

Sodium Lactate and Brain Relaxation (LSD)

Centre Hospitalier Universitaire de Besancon

Sodium LactateIntracranial HypertensionBrain Relaxation
Completed·Early Phase 1·ketamine

Intraoperative Ketamine for Patients Undergoing Total Joint Arthroplasty

Dartmouth-Hitchcock Medical Center

Pain, PostoperativeArthroplasty Complications
Completed·Phase 3·MDMA

A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·N/A·ketamine

Efficacy of Ketamine in Post Anesthesia Recovery Room

University of Alberta

Pain, PostoperativeKetamine Adverse ReactionPain, Refractory+2 more
Completed·Phase 3·ketamine

A Long-term Comparison of Esketamine Nasal Spray Versus Quetiapine Extended Release, Both in Combination With a Selective Serotonin Reuptake Inhibitor/Serotonin-Norepinephrine Reuptake Inhibitor, in Participants With Treatment Resistant Major Depressive Disorder

Janssen-Cilag International NV

Depressive Disorder, Major
Completed·Phase 1·ketamine

Low-Dose Ketamine in Children With ADNP Syndrome

Alexander Kolevzon

ADNP Syndrome
Completed·N/A·ketamine

Behavioral and Electrophysiological Effects of Ketamine in Treatment-Resistant Depression

Mclean Hospital

Major Depressive Disorder
Completed·Phase 2·psilocybin

The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression

COMPASS Pathways

Treatment Resistant Depression
Completed·N/A·Other

Long Term Follow Up Study to COMP 001 And COMP 003 Trials (P-TRD LTFU)

COMPASS Pathways

Treatment Resistant Depression
Completed·Phase 1·ketamine

Phase 1 Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual) and IV Midazolam or Ketamine

Melt Pharmaceuticals

Healthy Volunteers
Completed·N/A·Other

Characterization of Altered Waking States of Consciousness in Healthy Humans

University of Zurich

Altered Waking States of Consciousness in Healthy Humans
Completed·Phase 4·ketamine

Ketamine for Acute Pain Management After Trauma

The University of Texas Health Science Center, Houston

Trauma InjuryPainOpioid Use
Completed·Phase 4·ketamine

Low Dose Ketamine and Acute Pain Crisis

Rhode Island Hospital

Sickle Cell Crisis
Completed·Phase 2·MDMA

Open Label Study of MDMA-assisted Psychotherapy for Treatment of PTSD With Optional fMRI Sub-Study

MAPS Europe B.V.

PTSD
Completed·Phase 2·ketamine

Recovery After Total Intravenous Anesthesia With Ketofol Versus Mixture of Ketofol and Lidocaine for Short Pediatric Surgery

University Hospital of Split

Surgical Procedure, Unspecified
Completed·Phase 1·ketamine

A Study of Different Oral Thin Film (S)-Ketamine Formulations for Sublingual Administration in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·Phase 2·psilocybin

Clinical and Mechanistic Effects of Psilocybin in Alcohol Addicted Patients

University of Zurich

Alcohol Use Disorder
Completed·Phase 1·psilocybin

Comparative Acute Effects of LSD, Psilocybin and Mescaline

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·Other

Impact of Fingolimod Adherence on Outcomes

Novartis Pharmaceuticals

Multiple Sclerosis
Completed·Phase 4·ketamine

A Retrospective Effectiveness Trial of Ketamine-Assisted Psychotherapy in Adult Patients Coping With Mental Health

Field Trip Health

DepressionAnxietyPost Traumatic Stress Disorder
Completed·N/A·ketamine

Ketamine-Induced Brain Changes and Their Modulation by Lamotrigine

Charite University, Berlin, Germany

Emotions
Completed·Phase 1·ketamine

A Study of Sublingually Administered (S)-Ketamine Oral Solution in Healthy Participants

Janssen Research & Development, LLC

Healthy
Completed·N/A·Other

Patient Doctor Lies

University of Utah

Patient LyingPrivacy StatementsRisk Statements+2 more
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.