CompletedN/Aketamine
Ketamine for Pain Control After Severe Traumatic Injury
Sponsored by Medical College of Wisconsin
NCT ID
NCT04274361
Target Enrollment
93 participants
Start Date
2021-01-20
Est. Completion
2025-02-28
About This Study
This study evaluates if the early utilization of ketamine infusion therapy among acutely injured adult trauma hospital inpatients with an ISS \>15 will decrease the amount of opioid pain medication used as compared with placebo group. Ketamine infusion therapy initiated within 12 hours of hospital arrival will lead to decreased total opiate consumption (standardized to oral morphine equivalent units) in the first 24 and 48 hours compared to controls.
Conditions Studied
Interventions
- •Ketamine
- •Placebo
Eligibility
Age:18 Years - 64 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * Age 18-64 * ISS \>15 * Infusion can be started within 24 hrs of arrival to FMLH (time of injury irrelevant) * Admitted to Inpatient hospital trauma service (not Ortho/Plastics/Neurosurgery etc) Exclusion Criteria: * Age \<18 or \>64 * History of adverse reaction to ketamine therapy * Chronic opioid therapy defined as \> 3 weeks of \>30mg oral morphine equivalents per day * Current substance abuse with opioids including prescription and/or heroin * Intubation on arrival or need for urgent intubation on arrival * GCS \<13, significant traumatic brain injury, or suspicion of elevated intracranial pressure resulting in the patient's inability to communicate * History of psychosis * Active delirium * Glaucoma * Ischemic heart disease defined as active acute coronary syndrome * Severe, poorly controlled hypertension (SBP \>200) on more than two readings * Aortic Injury requiring HR and BP control * Concurrent use of monoamine oxidase inhibitors (MAOIs) * Pregnancy * Prisoners * Inability to start investigational drug infusion within 24 hours of arrival
Study Locations (1)
Froedtert Hospital
Milwaukee, Wisconsin, United States