Overview
higher_edPhase 4ketaminepsilocybinMDMAOtherDMT
Yale Program for Psychedelic Science — researching psilocybin for OCD, DMT safety and efficacy, and neural mechanisms of psychedelic compounds. Part of Yale School of Medicine's Department of Psychiatry.
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Research Areas
Clinical Pipeline(57)
Terminated·N/A·ketamine
Role Of Non-Specific Effects in The Treatment of Depression With Esketamine
Pre and Post Treatment PresentationsDepressive Episode
Enrolling by Invitation·N/A·ketamine
Long Term Follow Up KET-PD
Cognitive Behavior Therapy (CBT)Parkinson's Disease
Completed·Phase 1·psilocybin
Psilocybin for the Treatment of Cluster Headache
0.143 mg/kg Psilocybin or 10 mg PsilocybinCluster Headache
Completed·N/A·ketamine
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
Cognitive Behavioral Therapy CBTDepression and Suicide
Recruiting·Phase 3·ketamine
PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study
Racemic ketamineDepression
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin Microdosing on Cognition, Mood and Quality of Life
PsliocybinPsychedelic Microdosing Effects on Mood, Cognition, Subjective Well-being and MRI
Completed·N/A·ketamine
Cognitive Therapy to Sustain the Antidepressant Effects of Intravenous Ketamine in Treatment-resistant Depression
Cognitive behavioral therapy (CBT) and medicationDepressive Disorder, Major
Recruiting·Phase 2·ketamine
Imaging Depression in Parkinson's Disease
11C-UCB-JParkinson's Disease
Enrolling by Invitation·N/A·ketamine
Using Virtual Reality to Control the Audio-visual Inputs During Ketamine/Esketamine Treatment
Virtual realityDepression
Completed·Phase 1·ketamine
THC and Ketamine Effects in Humans: Relation to Neural Oscillations and Psychosis
Active Delta-9-THCCannabis
Withdrawn·Phase 1·MDMA
The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.
MDMAPost Traumatic Stress Disorder
Completed·Phase 1·Other
GABA-glutamate Interactions and Psychosis
iomazenilCognitive Dysfunction
Recruiting·N/A·ketamine
Imaging SV2A in Mood Disorders
KetamineMajor Depressive Disorder
Completed·Phase 2·ketamine
Ketamine Infusion for Obsessive-Compulsive Disorder
ketamineObsessive-compulsive Disorder
Terminated·Phase 2·ketamine
Ketamine in Borderline Personality Disorder
KetamineBorderline Personality Disorder
Completed·N/A·ketamine
PET Imaging of mGLuR5 With Drug Challenge
KetamineMajor Depressive Disorder
Recruiting·N/A·ketamine
The OBSERVE Protocol
SpravatoMajor Depression Disorder
Completed·Phase 1·psilocybin
Psilocybin for the Treatment of Migraine Headache
High Dose PsilocybinMigraine Headache
Withdrawn·Phase 2·ketamine
Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia
PropofolPatients With "ASA 3" Designation
Active, Not Recruiting·Phase 1·psilocybin
Effects of Repeated Psilocybin Dosing in OCD
PsilocybinObsessive-Compulsive Disorder
Terminated·Phase 2·ketamine
Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy
Ketamine infusionMajor Depressive Disorder
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
Psilocybin 10 mgChronic Low Back Pain (CLBP)
Withdrawn·Phase 2·ketamine
Trial of Ketamine and Lithium Therapy in Bipolar Depression
PlaceboBipolar Depression
Recruiting·Phase 1·ketamine
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
KetamineDepressive Disorder, Major
Recruiting·N/A·psilocybin
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Serotonergic PsychedelicOCD
Completed·Early Phase 1·ketamine
Ketamine Infusion for Social Anxiety Disorder
KetamineSocial Anxiety Disorder
Recruiting·Phase 1·psilocybin
Open-Label Psilocybin Study in Transdiagnostic Population
PsilocybinTransdiagnostic
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
Low Dose PsilocybinMajor Depressive Disorder
Recruiting·Phase 1·psilocybin
Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
PsilocybinOpioid Use Disorder
Completed·N/A·ketamine
The Effects of Ketamine and Guanfacine on Working Memory in Healthy Subjects
GuanfacineNMDA Receptor Function
Recruiting·Phase 2·ketamine
Enhancing Week-long Psychological Treatment for PTSD With Ketamine
KetaminePosttraumatic Stress Disorder
Recruiting·Phase 2·MDMA
MDMA in Borderline Personality Disorder
MDMABorderline Personality Disorder
Recruiting·Early Phase 1·psilocybin
Mechanistic Studies of Psilocybin in Headache Disorders
PsilocybinMigraine
Completed·Phase 1·ketamine
Ketamine for Low Mood States in the ER
ketamineDepression
Completed·Phase 1·psilocybin
Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study.
Psilocybin (0.25mg/kg)Obsessive-Compulsive Disorder
Completed·Early Phase 1·ketamine
Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling
KetamineDepression
Completed·N/A·ketamine
Ketamine/Placebo Family History Positive Study
Ketamine and PlaceboAlcoholism
Terminated·Phase 2·ketamine
Intensive 7-day Treatment for PTSD Combining Ketamine With Exposure Therapy
KetaminePosttraumatic Stress Disorder
Terminated·Phase 1·ketamine
The Sustained Effects of Ketamine
KetamineMental Disorders
Completed·Phase 2·ketamine
Ketamine for the Treatment of Depression in Parkinson's Disease
Ketamine InfusionParkinson's Disease
Completed·Phase 1·ketamine
Parallel Effects of Schizophrenia and N-methyl-D-aspartate (NMDA) Antagonism
ketamineSchizophrenia
Completed·Phase 1·ketamine
Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous Ketamine
KetamineDepression
Completed·Early Phase 1·ketamine
Characterizing Clinical and Pharmacological Neuroimaging Biomarkers
MRICognitive Impairment
Active, Not Recruiting·Phase 1·DMT
Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
0.1 mg/kg Dimethyltryptamine (DMT)Major Depressive Disorder
Completed·Phase 2·ketamine
Examining the Impact of Sirolimus on Ketamine's Antidepressant Effects
KetamineDepression
Recruiting·Phase 2·ketamine
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Perampanel 6 MGDepressive Disorder
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin as a Treatment for Chronic Pain in Smokers
Psilocybin (drug)Smokers With Chronic Pain
Terminated·Phase 2·ketamine
Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine
Ketamine InfusionAdolescent Suicide
Completed·Phase 4·ketamine
Ketamine Infusion for Adolescent Depression and Anxiety
KetamineMajor Depressive Disorder
Completed·Phase 1·psilocybin
Repeat Dosing of Psilocybin in Migraine Headache
PsilocybinMigraine Headache
Completed·Phase 1·ketamine
N-acetylcysteine and NMDA Antagonist Interactions
N-acetylcysteine and ketamineCognitive Dysfunction
Completed·Phase 1·ketamine
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial
KetamineDepressive Disorder, Major
Completed·Phase 1·ketamine
Ketamine for Depression and Alcohol Dependence
Ketalar (ketamine)Depression
Terminated·Phase 1·psilocybin
Effects of Psilocybin in Concussion Headache
Placebo oral capsulePost-Traumatic Headache
Completed·Phase 1·ketamine
Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects
KetamineHealthy Subjects
Recruiting·Phase 1·DMT
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)
0.3mg/kg/min Dimethyltryptamine + Normal Saline infusionAlcohol Use Disorder (AUD)
Completed·Phase 1·ketamine
Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects
Ketamine and Org 25935Healthy