Compare the Effect of Propofol vs. "Ketofol" on Hemodynamic Stability During Induction of General Anesthesia

About This Study

The purpose of this study is to compare the hemodynamic effects of a standardized induction of general anesthesia with either propofol or ketofol in patients with physical status classification ASA 3. The study will be a double blinded, randomized controlled trial (RCT) with two arms of treatment groups. One arm will consist of induction of general anesthesia using a mixture of 1.5mg/kg:0.75mg/kg Propofol/ketamine (ketofol) and the induction dose will be 1.5mg/kg of propofol and 0.75mg/kg of ketamine; the second arm will consist of induction of general anesthesia using propofol 2mg/kg. The primary outcome of the intervention will consist of hemodynamic changes during the first 30 minutes after induction of general anesthesia.

Conditions Studied

Interventions

• •Propofol
• •Propofol-Ketamine

Eligibility

Inclusion Criteria:

* Patients age 18-80 scheduled for elective surgery
* Physical status ASA 3.

Exclusion Criteria:

* Patients with a physical status of ASA 1,2, 4 or 5,
* Prior adverse reaction to propofol, ketamine or both

Study Locations (1)