Role Of Non-Specific Effects in The Treatment of Depression With Esketamine

Inclusion Criteria:

* Participants must be either male or female and at least 18 years old
* Deemed clinically appropriate to receive esketamine by a Yale Interventional Psychiatry physician.
* Written consent for the study procedures
* Ability and willingness, in the investigator's judgement, to comply with the study schedule, treatment plan, and other trial requirements for the duration of the study.

Exclusion Criteria:

* Hearing or visual impairment to the degree that would interfere with ability to view the presentation
* Difficulty in understanding spoken or written English
* Unable to provide informed consent
* Dementia or other cognitive disorder or intellectual disability that would impair the subject's ability to understand the presentation (per investigator judgment)
* Any other medical or psychiatric comorbidity that the investigator judges would put the participant at additional undue risk due to study participation or would impair subject's ability to participate in the study.
* Previous Esketamine or ketamine treatment
* Unable to give informed consent
* Was previously enrolled/randomized into the trial