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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 100 of 117 trials
Completed·Phase 2·MDMA

MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD

VA Loma Linda Health Care System

Post Traumatic Stress DisorderCombat Stress Disorders
Completed·N/A·Other

Patient Doctor Lies

University of Utah

Patient LyingPrivacy StatementsRisk Statements+2 more
Not Yet Recruiting·Phase 2·MDMA

MDMA-Assisted Therapy for Stress Disorders in Healthcare Workers

Nautilus Sanctuary

Post-Traumatic Stress DisorderAdjustment Disorders
Completed·Phase 2·MDMA

Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults

Lykos Therapeutics

Social Anxiety in Autistic Adults
Recruiting·Early Phase 1·MDMA

MDMA-Assisted Therapy for Pathological Narcissism

University of Washington

Narcissism
Completed·N/A·Other

Characterization of the Prosocial and Prosexual Effects of GHB

University of Zurich

Depressive Disorder, MajorBipolar DisorderAutistic Disorder
Completed·Phase 2·MDMA

Social Anxiety MDMA-Assisted Therapy Investigation

Jason B Luoma

Social Anxiety Disorder
Completed·Phase 1·MDMA

Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers

Lykos Therapeutics

Psychological Effects of Study Drug
Withdrawn·Phase 2·MDMA

MDMA-Assisted Psychotherapy for Treatment Resistant PTSD in Adolescents

University of California, Los Angeles

PTSD, Post Traumatic Stress DisorderAdolescentsPsychotherapy
Completed·Phase 2·MDMA

Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada)

Lykos Therapeutics

Posttraumatic Stress Disorder
Unknown·N/A·Other

Personality and Drug Use

Psychedelic Data Society

No Conditions Study Focus on Substance Use and Personality
Completed·N/A·MDMA

Exploring Mechanisms of Action in MDMA-assisted Psychotherapy for PTSD

Lykos Therapeutics

Posttraumatic Stress Disorder
Recruiting·Phase 2·MDMA

MDMA for AUD/PTSD Comorbidity

Carolina L Haass-Koffler

Alcohol Use DisorderPost Traumatic Stress Disorder
Completed·Phase 1·MDMA

Pharmacological Interaction Between Doxazosin and Methylenedioxymethamphetamine (MDMA)

University Hospital, Basel, Switzerland

Mood DisorderSubstance-Related DisordersAmphetamine-Related Disorders
Completed·N/A·MDMA

Naturalistic Study Into the Hangover Effects of MDMA

Utrecht Institute for Pharmaceutical Sciences

Hangover
Enrolling by Invitation·N/A·psilocybin

The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy Training

Felix Mueller

Personal Experience of Substance-assisted Therapy Using Psilocybin, MDMA, and LSD
Completed·Early Phase 1·MDMA

Drug Effects on Interpersonal Interaction

University of Chicago

Interaction, Social
Completed·Phase 3·MDMA

A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2)

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Phase 1·MDMA

Acute Effects of R- and S-MDMA in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·MDMA

The NeXT Study; The Netherlands XTC Toxicity Study

UMC Utrecht

Ecstasy (Drug)N-Methyl-3,4-MethylenedioxymethamphetaminePsychopathology
Withdrawn·Phase 1·MDMA

Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-2)

Lykos Therapeutics

Psychological Effects of Study Drug
Completed·Phase 1·MDMA

Effects of MDMA-like Substances in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 3·MDMA

A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1)

Lykos Therapeutics

Posttraumatic Stress Disorder
Recruiting·Phase 1·psilocybin

Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·MDMA

Group MDMA-therapy for Veterans With PTSD

Portland VA Research Foundation, Inc

PTSD
Completed·Phase 1·MDMA

Food Effects on Bioavailability of MDMA in Healthy Volunteers

Lykos Therapeutics

Pharmacokinetics
Recruiting·Early Phase 1·MDMA

MDMA-assisted Therapy for Fibromyalgia

Spaulding Rehabilitation Hospital

Fibromyalgia
Completed·Phase 2·MDMA

MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening Illness

Lykos Therapeutics

Anxiety
Completed·Early Phase 1·MDMA

Effects of MDMA and Methylphenidate on Social Cognition

University Hospital, Basel, Switzerland

Social Cognition
Terminated·Phase 2·MDMA

MDMA-assisted Therapy in People With Anxiety Related to Advanced Stage Cancer

Brigham and Women's Hospital

Anxiety DisorderCancer
Recruiting·Phase 2·MDMA

MDMA-assisted Therapy for Adjustment Disorder (AD) in Dyads of Patients With Cancer and a Concerned Significant Other

Sunstone Medical

CancerAdjustment Disorders
Terminated·Phase 2·MDMA

Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD

Lykos Therapeutics

PTSD
Recruiting·Phase 1·MDMA

MDMA-Assisted Therapy for Mental Healthcare Providers

Rachel Yehuda

Mental Wellbeing
Withdrawn·Phase 1·MDMA

The Effects of MDMA on Prefrontal and Amygdala Activation in PTSD.

Yale University

Post Traumatic Stress Disorder
Completed·N/A·Other

Correlates of Anxiety Associated With a Life-threatening Illness

Lykos Therapeutics

Anxiety
Recruiting·Phase 1·MDMA

Comparative Acute Effects of R-MDMA and S-MDMA in Healthy Participants

University Hospital, Basel, Switzerland

Healthy
Recruiting·Phase 2·MDMA

Dose Optimization of MDMA-Assisted Therapy for PTSD

Bronx VA Medical Center

Posttraumatic Stress Disorder
NO_LONGER_AVAILABLE·N/A·MDMA

A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTSD

Lykos Therapeutics

Post Traumatic Stress Disorder
Completed·N/A·MDMA

Clinical Pharmacology of MDA [3,4-methylenedioxyamphetamine]

California Pacific Medical Center Research Institute

Healthy
Completed·Phase 1·MDMA

Neurobiology and Pharmacokinets of Acute MDMA Administration

National Institute on Drug Abuse (NIDA)

Substance-Related Disorders
Completed·Phase 2·MDMA

Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD

Lykos Therapeutics

Posttraumatic Stress Disorder
Recruiting·Phase 1·psilocybin

Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)

Johns Hopkins University

Posttraumatic Stress Disorder
Completed·Phase 1·MDMA

-Methylenedioxymethamphetamine (MDMA, Ecstasy) Induced Changes in Drug Metabolism: Gender and Genetic Polymorphisms

Parc de Salut Mar

MetabolismInteraction
Completed·N/A·MDMA

Effects of MDMA on Social and Emotional Processing

University of Chicago

Drug Addiction
Terminated·Phase 2·MDMA

Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSD

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Early Phase 1·MDMA

Prosocial Effects of MDMA

University of Chicago

MDMA ('Ecstasy')Social Interaction
Withdrawn·Phase 2·MDMA

Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in Veterans

Lykos Therapeutics

PTSD
Completed·Phase 1·Other

Abuse Liability and Human Pharmacology of Mephedrone

Parc de Salut Mar

Amphetamine-Related Disorders
Unknown·N/A·MDMA

Sustaining Remission From PTSD Using Tuned Vibroacoustic Stimulation (TVS) Following MDMA-Assisted Psychotherapy

Apollo Neuroscience, Inc.

Stress Disorders, Post-Traumatic
Recruiting·Phase 2·MDMA

MDMA for Co-occurring PTSD and OUD After Childbirth

University of New Mexico

Stress Disorders, Post-TraumaticOpioid Use Disorder
Not Yet Recruiting·Phase 1·MDMA

MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

Lykos Therapeutics

PharmacokineticsHepatic Impairment
Completed·Early Phase 1·MDMA

Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction

University Hospital, Basel, Switzerland

Healthy
Recruiting·Phase 2·MDMA

MDMA-Assisted Therapy for Veterans With Moderate to Severe Post Traumatic Stress Disorder

Stephen Robert Marder

Post Traumatic Stress Disorder
Completed·Early Phase 1·MDMA

Effects of Methylphenidate, Modafinil, and MDMA on Emotion-processing in Humans: A Pharmaco-fMRI Study

University Hospital, Basel, Switzerland

HealthySubstance-related DisorderMood Disorder
Completed·Early Phase 1·MDMA

Effects of Stimulants on Behavioral and Neural Markers of Social Motivation, Ability, and Neural Markers of Social Function

University of Chicago

Stimulant UseMDMA ('Ecstasy')Social Behavior+1 more
Recruiting·Phase 2·Other

Ecstasy to Alleviate SEvere Chronic Neuropathic Pain Trial

Unity Health Toronto

Chronic Neuropathic Pain
Unknown·Phase 1·MDMA

Abuse Potential and Human Pharmacology of Methylone

Germans Trias i Pujol Hospital

Substance UseHealthy Subjects
Enrolling by Invitation·Phase 2·MDMA

MDMA Plus Exposure Therapy for PTSD

Emory University

PTSD
Recruiting·Phase 1·psilocybin

Investigation of Psychedelic Effects in Psychoactive Substances

Johns Hopkins University

Psychedelic Effects in Healthy Volunteers
Completed·Phase 2·MDMA

Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Phase 2·MDMA

Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Early Phase 1·MDMA

Effects of Drugs on Responses to Brain and Emotional Processes

University of Chicago

Autism Spectrum DisorderHealthy
Completed·Phase 2·MDMA

A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD)

Remedy

Post Traumatic Stress Disorder
Completed·Phase 1·MDMA

Interaction Between Duloxetine and 3,4-Methylenedioxymethamphetamine (MDMA, Ecstasy)

University Hospital, Basel, Switzerland

Mood DisorderSubstance-Related DisordersAmphetamine-Related Disorders
Recruiting·Phase 2·MDMA

A Phase 2A Trial of MM402 for Autism Spectrum Disorder

Definium Therapeutics US, Inc.

Autism Spectrum DisorderASD
Completed·Phase 1·psilocybin

Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·MDMA

Effects of MDMA on Emotional and Social Memories

University of Chicago

Healthy
Completed·N/A·MDMA

Study of the Effects of MDMA/Ecstasy on Water Regulation, Sleep, and Cognition.

California Pacific Medical Center Research Institute

MDMA Discontinuation Syndrome
Completed·Early Phase 1·MDMA

Role of Dopamine, Serotonin and 5-HT2A Receptors in Emotion Processing

University Hospital, Basel, Switzerland

Healthy
Recruiting·Phase 2·MDMA

MDMA-assisted Prolonged Exposure Therapy for Comorbid Alcohol Use Disorder and Post-traumatic Stress Disorder

University of Sydney

PTSDAlcohol Use DisorderAlcohol Dependence+2 more
Withdrawn·N/A·Other

Personality and Drug Use (PDU)

Quantified Citizen Technologies Inc.

Personality
Completed·Phase 3·MDMA

A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD

Lykos Therapeutics

PTSD
Completed·N/A·MDMA

Perceptions of MDMA-Assisted Therapy Among Veterans With PTSD

Albany Research Institute, Inc.

Post Traumatic Stress Disorder
Unknown·Phase 3·MDMA

Epigenetics and MDMA-Assisted Psychotherapy for PTSD

University of Southern California

PTSD
Completed·Phase 2·MDMA

Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSD

Lykos Therapeutics

Posttraumatic Stress Disorder (PTSD)
Completed·Phase 1·MDMA

Emotional Effects of Methylphenidate and MDMA in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·psilocybin

Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans

University of Zurich

Healthy
Recruiting·Phase 2·MDMA

MDMA-Assisted CBCT for PTSD vs CBCT RCT

Remedy

Post Traumatic Stress Disorder
Completed·Phase 2·MDMA

Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD

Lykos Therapeutics

PTSD
Completed·Phase 1·MDMA

Influence of Bupropion on the Effects of MDMA

University Hospital, Basel, Switzerland

HealthySubstance-related Disorders
Completed·N/A·MDMA

Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSD

Lykos Therapeutics

PTSD
Recruiting·Phase 2·MDMA

MDMA-Assisted CBT for OCD (MDMA-CBT4OCD Study)

Carolyn Rodriguez

Obsessive-Compulsive Disorder
Completed·Phase 1·MDMA

Effects of MDMA Co-administration on the Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·MDMA

Interaction Between Reboxetine and 3,4-Methylenedioxymethamphetamine: Pharmacodynamics (PD) and Pharmacokinetics (PK)

University Hospital, Basel, Switzerland

Mood DisorderSubstance-related DisordersAmphetamine-related Disorders
Completed·Phase 1·MDMA

Acute Effects of 3,4-methylenedioxymethamphetamine (MDMA) With and Without a Booster Dose

University Hospital, Basel, Switzerland

Healthy
Unknown·Phase 1·MDMA

Bristol Imperial MDMA in Alcoholism Study

Imperial College London

Alcohol Use Disorder
Completed·N/A·MDMA

Stanford Regulating Circuits of the Brain Study - MDMA

Stanford University

Healthy
Terminated·Phase 2·MDMA

Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Phase 1·MDMA

Pharmacological Interaction Between Clonidine and Methylenedioxymethamphetamine (MDMA)

University Hospital, Basel, Switzerland

Mood DisorderSubstance-Related DisordersAmphetamine-Related Disorders
Recruiting·Phase 2·MDMA

MDMA in Borderline Personality Disorder

Yale University

Borderline Personality Disorder
Unknown·Phase 2·MDMA

Preliminary Effectiveness of Individual and Group MDMA-assisted Therapy for Israeli Veterans With PTSD and Moral Injury.

HaEmek Medical Center, Israel

Post Traumatic Stress DisorderMoral InjuryMDMA ('Ecstasy')
Completed·N/A·MDMA

Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging

University of Zurich

Amphetamine-Related DisordersAmphetamine Abuse
Completed·Phase 1·Other

Mood Effects of Serotonin Agonists

University of Chicago

Healthy
Completed·Phase 1·Other

Effects of Hallucinogens and Other Drugs on Mood and Performance

Johns Hopkins University

Healthy
Completed·Phase 3·MDMA

MDMA-assisted Brief Cognitive Behavioral Conjoint Therapy for PTSD

Dr. Leslie Morland

PTSDRelational Problems
Completed·Phase 2·MDMA

MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Phase 1·MDMA

Pharmacological Interaction Between Pindolol and MDMA (3,4-Methylenedioxymethamphetamine)

University Hospital, Basel, Switzerland

Mood DisorderSubstance-Related DisordersAmphetamine-Related Disorders
Completed·N/A·MDMA

Role of Serotonin in Acute and Subacute MDMA Effects

California Pacific Medical Center Research Institute

MDMA Mechanism of Action
Completed·Phase 1·Other

Effect of Stimulant Drugs on Social Perception

University of Chicago

HealthyMDMA ('Ecstasy')
Withdrawn·Phase 2·MDMA

A Multi-Site Study of MDMA-Assisted Psychotherapy for Eating Disorders

Lykos Therapeutics

Anorexia Nervosa Restricting TypeBinge-Eating Disorder

More trials available. Refine your search to see specific results.

How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.