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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 193240 of 1695 trials
Completed·Phase 2·MDMA

A Phase 2 Open-Label Treatment Development Study of MDMA-Assisted Cognitive Processing Therapy (CPT) for Posttraumatic Stress Disorder (PTSD)

Remedy

Post Traumatic Stress Disorder
Completed·Phase 4·ketamine

Comparison of Nebulized Ketamine to Intravenous Sub-Dissociative Dose Ketamine for Pain

Antonios Likourezos

Pain
Completed·Phase 4·ketamine

Low Dose Ketamine for Blunt Thoracic Trauma

North Memorial Health Care

Blunt Injury of ThoraxMultiple Rib Fractures, Involving Three Ribs
Completed·Early Phase 1·ketamine

Glutamate and Opioid Mechanisms of Antidepressant Response to Ketamine

King's College London

Depressive Disorder, Treatment-Resistant
Completed·Phase 1·DMT

Single Ascending Dose Study With 5-MeO-DMT in Healthy Subjects

Beckley Psytech Limited

Pharmacokinetics in Healthy Adults
Completed·Phase 1·ketamine

Study of SAGE-904 Using a Ketamine Challenge to Evaluate Electrophysiology, Safety, Tolerability, and Pharmacokinetics in Healthy Participants

Supernus Pharmaceuticals, Inc.

Healthy Volunteer
Completed·N/A·ayahuasca

Entheogen Resurgence

Vireo Health

Psychedelic Experiences
Completed·Phase 1·ketamine

Repeated Neurocognitive Measurements in Depressed Patients

Rebecca Price

Depression, Unipolar
Completed·Phase 3·ketamine

Ketamine As an Adjunctive Therapy for Major Depression (2)

University of Dublin, Trinity College

Major Depressive EpisodeUnipolar DepressionBipolar Depression
Completed·N/A·ketamine

Simultaneous Application of Ketamine and Lidocaine During an Ambulatory Infusion Therapy as a Treatment Option in Refractory Chronic Pain Conditions

University Hospital, Basel, Switzerland

Chronic Pain
Completed·Phase 2·Other

Pharmacokinetic Study of Intranasal CT001 in Children 1-17 Years of Age Undergoing Elective Surgical Procedures

Cessatech A/S

Analgesia
Completed·Phase 2·psilocybin

Psilocybin Therapy for Depression and Anxiety in Parkinson's Disease

Joshua Woolley, MD, PhD

Parkinson DiseaseDepressionAnxiety
Completed·Phase 1·mescaline

Role of the Serotonin 5-HT2A Receptor in Mescaline-induced Altered States of Consciousness

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·psilocybin

Repeat Dosing of Psilocybin in Migraine Headache

Yale University

Migraine Headache
Completed·Phase 4·Other

Opioid Free Anesthesia and Bariatric Surgery

Northwell Health

Postoperative Quality of Recovery
Completed·Early Phase 1·MDMA

Drug Effects on Interpersonal Interaction

University of Chicago

Interaction, Social
Completed·Phase 2·MDMA

MDMA-Assisted Psychotherapy in Veterans With Combat-Related, Refractory PTSD

VA Loma Linda Health Care System

Post Traumatic Stress DisorderCombat Stress Disorders
Completed·Phase 1·ketamine

A Proof-of-Concept Trial on the Effect of Ketamine on Fatigue

National Institute of Nursing Research (NINR)

Fatigue
Completed·Phase 3·DMT

Open Label Randomized Multicenter to Assess Efficacy & Tolerability of Ofatumumab 20mg vs. First Line DMT in RMS

Novartis Pharmaceuticals

Multiple Sclerosis
Completed·Phase 2·ketamine

A Study of MELT-300 (Midazolam and Ketamine Sublingual Tablets) for Sedation and Intraoperative Ocular Analgesia in Participants Undergoing Cataract Extraction With Lens Replacement (CELR)

Melt Pharmaceuticals

Cataract
Completed·Phase 1·DMT

Pharmacokinetics of GH001 in Healthy Volunteers

GH Research Ireland Limited

Healthy Volunteers
Completed·Phase 1·DMT

Effects of Dimethyltryptamine in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·ketamine

The Effect of Opioid-Free Anesthesia in TMJ Surgery

Massachusetts General Hospital

Temporomandibular Joint Disorders
Completed·Phase 2·psilocybin

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression

Central Institute of Mental Health, Mannheim

Treatment-resistant Depression
Completed·Phase 2·ketamine

Adding Trauma-focused Psychotherapy to Ketamine Treatment for Chronic PTSD

Icahn School of Medicine at Mount Sinai

PTSD
Completed·Early Phase 1·psilocybin

Precision Functional Brain Mapping in Psilocybin

Washington University School of Medicine

Psilocybin
Completed·Phase 1·psilocybin

Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study

Imperial College London

Anorexia Nervosa
Completed·Phase 1·psilocybin

Pilot RECAP Study in Healthy Volunteers

University of Wisconsin, Madison

Psychedelic ExperiencesAmnesia
Completed·N/A·DMT

Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS): Extension of the DISCOMS Study

University of Colorado, Denver

Multiple Sclerosis
Completed·Phase 2·psilocybin

Evaluation of Psilocybin in Anorexia Nervosa: Safety and Efficacy

University of California, San Diego

Anorexia Nervosa
Completed·Phase 4·ketamine

Ketamine Versus Fentanyl for Surgical Abortions

University of Washington

Abortion in First TrimesterPain, ProceduralOpioid Use
Completed·Phase 4·ketamine

A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment

Janssen-Cilag Ltd.

Depressive Disorder, Major
Completed·Phase 4·ketamine

Effect of Postoperative Single Dose of Ketamine on Pain After Mastectomy

NYU Langone Health

Postoperative Pain
Completed·Phase 4·ketamine

An Efficacy and Safety of Proprietary Formulations of Oral Ketamine + Aspirin in Treatment of Acute Headache

Antonios Likourezos

Pain
Completed·Phase 4·ketamine

A Comparison of Proprietary Formulations of Oral Ketamine + Aspirin and Oral Ketamine Alone for Musculoskeletal Pain

Antonios Likourezos

Pain
Completed·Phase 1·ketamine

Modified Ketogenic Diet and Ketamine for Anorexia Nervosa

Homeostasis Therapeutics, LLC

Anorexia Nervosa
Completed·Phase 4·ketamine

The Impact of Perioperative Ketamine Infusion on Surgical Recovery

Vanderbilt University Medical Center

Opioid UseEnhanced Recovery After SurgeryAnesthesia+2 more
Completed·Phase 1·ibogaine

A Study of Oral Ibogaine in Opioid Withdrawal

atai Therapeutics, Inc.

Opiate Withdrawal Syndrome
Completed·Phase 1·ketamine

Study of CT001 in Healthy Volunteers

Cessatech A/S

Bioavailability
Completed·Phase 2·ketamine

Ketamine-enhanced Prolonged Exposure Therapy in PTSD

VA Office of Research and Development

PTSD
Completed·Phase 3·MDMA

A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD

Lykos Therapeutics

PTSD
Completed·N/A·ketamine

Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention

Yale University

Depression and Suicide
Completed·N/A·MDMA

Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSD

Lykos Therapeutics

PTSD
Completed·N/A·Other

RelieVRx for Total Knee Arthroplasty (TKA) for the Reduction of Acute Postoperative Pain and Opioid Use

AppliedVR Inc.

Opioid UseArthropathy of KneePain, Postoperative
Completed·Phase 2·psilocybin

Safety and Efficacy of Psilocybin for Body Dysmorphic Disorder

New York State Psychiatric Institute

Body Dysmorphic Disorders
Completed·N/A·Other

Effects of Dimethyl Fumarate on Cognitive Performance and Brain Abnormalities in Multiple Sclerosis.

IRCCS Centro Neurolesi Bonino Pulejo

Multiple Sclerosis
Completed·N/A·MDMA

Circulating Oxytocin Changes in Response to the Oxytocin System Stimulator MDMA in Patients With Diabetes Insipidus and Healthy Controls

University Hospital, Basel, Switzerland

Diabetes Insipidus
Completed·Phase 1·DMT

SPL026 (DMT Fumarate) in Healthy Subjects and MDD Patients

Small Pharma Ltd

Major Depressive Disorder
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.